The Effects of Asprosin on Exercise-Intervention in Metabolic Diseases

doi:10.3389/fphys.2022.907358

科研成果详情

名称	The Effects of Asprosin on Exercise-Intervention in Metabolic Diseases
作者	Liu, Lifei 1,2; Liu, Yuhao 3,4; Huang, Mei 1; Zhang, Miao 1; Zhu, Chenyu 1; Chen, Xi 5; Bennett, Samuel 4; Xu, Jiake 4; Zou, Jun 1
发表期刊	FRONTIERS IN PHYSIOLOGY
语种	英语
原始文献类型	Review
关键词	asprosin exercise metabolism disease T2DM obesity pcos
其他关键词	SKELETAL-MUSCLE ; DIABETES-MELLITUS ; INSULIN ; GLUCOSE ; CLASSIFICATION ; STRESS
摘要	Fibrillin is the major constituent of extracellular microfibrils, which are distributed throughout connective tissues. Asprosin is derived from the C-terminal region of the gene, which encodes profibrillin that undergoes cleavage by furin protein. In response to fasting with low dietary glucose, asprosin is released as a secreted factor from white adipose tissue, and is transported to the liver for the mediation of glucose release into the blood circulation. Through binding to OLFR734, an olfactory G-protein-coupled receptor in liver cells, asprosin induces a glucogenic effect to regulate glucose homeostasis. Bioinformatics analyses revealed that the gene is abundantly expressed in human skeletal muscle-derived mesoangioblasts, osteoblast-like cells, and mesenchymal stem cells, indicating that the musculoskeletal system might play a role in the regulation of asprosin expression. Interestingly, recent studies suggest that asprosin is regulated by exercise. This timely review discusses the role of asprosin in metabolism, its receptor signalling, as well as the exercise regulation of asprosin. Collectively, asprosin may have a vital regulatory effect on the improvement of metabolic disorders such as diabetes mellitus and obesity via exercise.
资助项目	National Natural Science Foundation of China [82104883, 81572242]; Shanghai Key Laboratory of Human Sport Competence Development and Maintenance (Shanghai University of Sport) [11DZ2261100]; Science Technology Planning Project of Guangzhou [202102020930]; NHMRC [APP1163933]
出版者	FRONTIERS MEDIA SA
出版地	LAUSANNE
EISSN	1664-042X
卷号	13
DOI	10.3389/fphys.2022.907358
页数	9
WOS类目	Physiology
WOS研究方向	Physiology
WOS记录号	WOS:000831182100001
收录类别	SCIE
发布日期	2022-07-11
PubMed ID	35899030
引用统计	被引频次[WOS]：0 [WOS记录] [WOS相关记录]
文献类型	其他
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/154651
专题	体育科学部
通讯作者	Zou, Jun
作者单位	1.Shanghai Univ Sport, Sch Kinesiol, Shanghai, Peoples R China; 2.Peoples Hosp Liaoning Prov, Dept Rehabil, Shenyang, Peoples R China; 3.Guangzhou Univ Chinese Med, Affiliated Hosp 1, Dept Orthopaed, Guangzhou, Peoples R China; 4.Univ Western Australia, Sch Biomed Sci, Perth, WA, Australia; 5.Wenzhou Med Univ, Sch Sports Sci, Wenzhou, Peoples R China
推荐引用方式 GB/T 7714	Liu, Lifei,Liu, Yuhao,Huang, Mei,et al. The Effects of Asprosin on Exercise-Intervention in Metabolic Diseases. 2022.