Damage associated molecular patterns and neutrophil extracellular traps in acute pancreatitis

doi:10.3389/fcimb.2022.927193

科研成果详情

名称	Damage associated molecular patterns and neutrophil extracellular traps in acute pancreatitis
作者	Zhou, Xiaoying1,2; Jin, Shengchun 2; Pan, Jingyi 2; Lin, Qingyi 2; Yang, Shaopeng 2; Ambe, Peter C.3; Basharat, Zarrin 4; Zimmer, Vincent 5,6; Wang, Wei7,8; Hong, Wandong1
发表期刊	FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
语种	英语
原始文献类型	Review
关键词	DAMPs (damage-associated molecular patterns) NETs (neutrophil extracellular traps) acute pancreatitis (AP) HMGB1 (high mobility group box 1) HSP (heat shock protein) histone
其他关键词	HEAT-SHOCK PROTEINS ; GROUP BOX 1 ; PERSISTENT ORGAN FAILURE ; MOBILITY GROUP BOX-1 ; CIRCULATING MITOCHONDRIAL-DNA ; TISSUE-DAMAGE ; SOLUBLE CD73 ; CELL-DEATH ; INFLAMMATORY RESPONSES ; THROMBIN GENERATION
摘要	Previous researches have emphasized a trypsin-centered theory of acute pancreatitis (AP) for more than a century. With additional studies into the pathogenesis of AP, new mechanisms have been explored. Among them, the role of immune response bears great importance. Pro-inflammatory substances, especially damage-associated molecular patterns (DAMPs), play an essential role in activating, signaling, and steering inflammation. Meanwhile, activated neutrophils attach great importance to the immune defense by forming neutrophil extracellular traps (NETs), which cause ductal obstruction, premature trypsinogen activation, and modulate inflammation. In this review, we discuss the latest advances in understanding the pathological role of DAMPs and NETs in AP and shed light on the flexible crosstalk between these vital inflammatory mediators. We, then highlight the potentially promising treatment for AP targeting DAMPs and NETs, with a focus on novel insights into the mechanism, diagnosis, and management of AP.
资助项目	Zhejiang Medical and Health Science and Technology Plan Project; Wenzhou Science and Technology Bureau; [2022KY886]; [Y2020010]
出版者	FRONTIERS MEDIA SA
出版地	LAUSANNE
ISSN	2235-2988
卷号	12
DOI	10.3389/fcimb.2022.927193
页数	21
WOS类目	Immunology ; Microbiology
WOS研究方向	Immunology ; Microbiology
WOS记录号	WOS:000844404900001
收录类别	SCIE
发布日期	2022-08-12
PubMed ID	36034701
引用统计	被引频次[WOS]：0 [WOS记录] [WOS相关记录]
文献类型	其他
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/154614
专题	附属第一医院_肝胆外科第一临床医学院（信息与工程学院）、附属第一医院精神医学学院其他_附属康宁医院（温州市康宁医院）
通讯作者	Hong, Wandong
作者单位	1.Wenzhou Med Univ, Dept Gastroenterol & Hepatol, Affiliated Hosp 1, Wenzhou, Peoples R China; 2.Wenzhou Med Univ, Sch Clin Med Sci 1, Wenzhou, Peoples R China; 3.Vinzenz Pallotti Hosp Bensberg, Dept Gen Surg Visceral Surg & Coloproctol, Bensberg, Germany; 4.Univ Karachi, Jamil Ur Rahman Ctr Genome Res, Int Ctr Chem & Biol Sci, Dr Panjwani Ctr Mol Med & Drug Res, Karachi, Pakistan; 5.Marienhausklin St Josef Kohlhof, Dept Med, Neunkirchen, Germany; 6.Saarland Univ, Saarland Univ Med Ctr, Dept Med 2, Homburg, Germany; 7.Wenzhou Med Univ, Sch Mental Hlth, Wenzhou, Peoples R China; 8.Wenzhou Med Univ, Affiliated Wenzhou Kangning Hosp, Zhejiang Prov Clin Res Ctr Mental Disorders, Wenzhou, Peoples R China
第一作者单位	肝胆外科; 第一临床医学院（信息与工程学院）、附属第一医院
推荐引用方式 GB/T 7714	Zhou, Xiaoying,Jin, Shengchun,Pan, Jingyi,et al. Damage associated molecular patterns and neutrophil extracellular traps in acute pancreatitis. 2022.