Effect of miR-34b/c rs4938723 T > C on pediatric glioma susceptibility

doi:10.1002/prm2.12067

科研成果详情

题名	Effect of miR-34b/c rs4938723 T > C on pediatric glioma susceptibility
作者	Jia, Xingyu 1,2; Chen, Wenchao 3; Chen, Wei 4; Liao, Yuxiang 5; Zhou, Jingying 6,7; Yuan, Li 1; Lin, Huiran 8; Bian, Jun 9
发表日期	2022-06
发表期刊	PRECISION MEDICAL SCIENCES 影响因子和分区
语种	英语
原始文献类型	Article
关键词	glioma miR-34b c polymorphism rs4938723 susceptibility
其他关键词	PROMOTER REGION ; RISK ; POLYMORPHISM ; P53 ; ASSOCIATION ; MICRORNAS ; CANCER ; GENE ; PROLIFERATION ; TEMOZOLOMIDE
摘要	Gliomas, the most common type of primary intracranial tumor, arise from the brain's glial cells and constitute 30% of all brain and central nervous system tumors. MiR-34b/c plays an important role in colorectal cancer and other cancers, but its role in glioma is unknown. In this study, we attempted to assess the effect of rs4938723 T > C in miR-34b/c on the susceptibility of glioma Chinese children. Odds ratios and 95% confidence intervals (CIs) were calculated to evaluate the association between the selected polymorphism and glioma susceptibility. Our results showed that there is no significant association between this polymorphism and the risk of glioma in Chinese children. However, stratified analysis showed that the rs4938723 TC/CC genotype significantly reduced the risk of glioma in participants under 60 months of age (adjusted OR = 0.56, 95% CI = 0.35-0.88, p = .013). Overall, our study indicates that miR-34b/c rs4938723 T > C polymorphism may have a weak influence on glioma susceptibility. Nevertheless, these findings need to be validated in well-designed studies with larger sample sizes and different populations.
资助项目	National Natural Science Foundation of China [81802346]
出版者	WILEY
出版地	HOBOKEN
ISSN	2642-2514
卷号	11 期号:2 页码:82-86
DOI	10.1002/prm2.12067
页数	5
WOS类目	Medicine, Research & Experimental
WOS研究方向	Research & Experimental Medicine
WOS记录号	WOS:000829297300001
收录类别	ESCI
通讯作者地址	[Lin, Huiran]Macau Univ Sci & Technol, Fac Med, Macau 999078, Peoples R China. ; [Bian, Jun]Xi An Jiao Tong Univ, Xian Childrens Hosp, Affiliated Childrens Hosp, Dept Gen Surg, 69 Xiju Court Lane, Xian 710003, Shaanxi, Peoples R China.
引用统计	被引频次[WOS]：0 [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/154591
专题	附属第二医院_血液内科第二临床医学院，附属第二医院、育英儿童医院
通讯作者	Lin, Huiran; Bian, Jun
作者单位	1.Guangzhou Med Univ, Guangzhou Women & Childrens Med Ctr, Dept Pathol, Guangzhou, Guangdong, Peoples R China; 2.Jinan Univ, Sch Med, Guangzhou, Guangdong, Peoples R China; 3.Jinan Univ, Affiliated Hosp 1, Dept Pediat, Guangzhou, Peoples R China; 4.Guangzhou Med Univ, Guangzhou Women & Childrens Med Ctr, Guangzhou Inst Pediat, Dept Pediat Surg,Guangdong Prov Key Lab Res Struc, Guangzhou, Guangdong, Peoples R China; 5.Cent South Univ, Xiangya Hosp, Dept Neurosurg, Changsha, Peoples R China; 6.Wenzhou Med Univ, Affiliated Hosp 2, Dept Hematol, Wenzhou, Zhejiang, Peoples R China; 7.Wenzhou Med Univ, Yuying Childrens Hosp, Wenzhou, Zhejiang, Peoples R China; 8.Macau Univ Sci & Technol, Fac Med, Macau 999078, Peoples R China; 9.Xi An Jiao Tong Univ, Xian Childrens Hosp, Affiliated Childrens Hosp, Dept Gen Surg, 69 Xiju Court Lane, Xian 710003, Shaanxi, Peoples R China
推荐引用方式 GB/T 7714	Jia, Xingyu,Chen, Wenchao,Chen, Wei,et al. Effect of miR-34b/c rs4938723 T > C on pediatric glioma susceptibility[J]. PRECISION MEDICAL SCIENCES,2022,11(2):82-86.
APA	Jia, Xingyu., Chen, Wenchao., Chen, Wei., Liao, Yuxiang., Zhou, Jingying., ... & Bian, Jun. (2022). Effect of miR-34b/c rs4938723 T > C on pediatric glioma susceptibility. PRECISION MEDICAL SCIENCES, 11(2), 82-86.
MLA	Jia, Xingyu,et al."Effect of miR-34b/c rs4938723 T > C on pediatric glioma susceptibility".PRECISION MEDICAL SCIENCES 11.2(2022):82-86.