Fibroblast-like cells Promote Wound Healing via PD-L1-mediated Inflammation Resolution

doi:10.7150/ijbs.69890

科研成果详情

题名	Fibroblast-like cells Promote Wound Healing via PD-L1-mediated Inflammation Resolution
作者	Wang, Xiao-Hui 1,3; Guo, Wei 1; Qiu, Wei1,2; Ao, Luo-Quan 1; Yao, Meng-Wei 1; Xing, Wei 1; Yu, Yang 1; Chen, Quan 1; Wu, Xiao-Feng 1; Li, Zhan 1; Hu, Xue-Ting 1; Xu, Xiang 1
发表日期	2022
发表期刊	INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES 影响因子和分区
语种	英语
原始文献类型	Article
关键词	PD-L1 FGF-2 TGF-?1 Fibroblast Wound healing Inflammation resolution
其他关键词	IMMUNORESISTANCE ; TISSUE ; PD-L1
摘要	Chronic non-healing wounds fail to progress beyond the inflammatory phase, characterized by a disorder of inflammation resolution. PD-1/PD-L1, a major co-inhibitory checkpoint signaling, plays critical roles in tumor immune surveillance and the occurrence of inflammatory or autoimmune diseases, but its roles in wound healing remains unclear. Here, we described a novel function of PD-L1 in fibroblast-like cells as a positive regulator of wound healing. PD-L1 dynamically expressed on the fibroblast-like cells in the granulation tissue during wound healing to form a wound immunosuppressive microenvironment, modulate macrophages polarization from M1-type to M2-type, and initiates resolution of inflammation, finally accelerate wound healing. Loss of PD-L1 delayed wound healing, especially in mice with LPS-induced severe inflammation. Furthermore, the mainly regulatory mechanism is that combination of FGF-2 and TGF-??1 promotes PD-L1 translation in fibroblasts through enhancing the eIF4E availability regulated by both PI3K-AKT-mTOR-4EBP1 and p38-ERK-MNK signaling pathways. Our results reveal the positive role of PD-L1 in wound healing, and provide a new strategy for the treatment of chronic wounds.
资助项目	National Natural Science Foundation of China [81801585, 81871568]; Military Research and Development Program [2019CXJSB017, 2019XYY21]; Military Medicine Frontier Innovation Capability Training Program [2019CXJSC033, 18CXZ002]
出版者	IVYSPRING INT PUBL
出版地	LAKE HAVEN
ISSN	1449-2288
卷号	18 期号:11 页码:4388-4399
DOI	10.7150/ijbs.69890
页数	12
WOS类目	Biochemistry & Molecular Biology ; Biology
WOS研究方向	Biochemistry & Molecular Biology ; Life Sciences & Biomedicine - Other Topics
WOS记录号	WOS:000832879400009
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
Pubmed记录号	35864974
Scopus记录号	2-s2.0-85134004118
通讯作者地址	[Hu, Xue-Ting]Department of Stem Cell & Regenerative Medicine,State Key Laboratory of Trauma,Burn and Combined Injury,Daping Hospital,Army Medical University,No. 10, Changjiang Branch Road, Yuzhong District,Chongqing,400042,China ; [Xu, Xiang]Department of Stem Cell & Regenerative Medicine,State Key Laboratory of Trauma,Burn and Combined Injury,Daping Hospital,Army Medical University,No. 10, Changjiang Branch Road, Yuzhong District,Chongqing,400042,China
scopus学科分类	Ecology, Evolution, Behavior and Systematics;Applied Microbiology and Biotechnology;Molecular Biology;Developmental Biology;Cell Biology
引用统计	被引频次[WOS]：0 [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/154570
专题	附属第一医院_皮肤科
通讯作者	Hu, Xue-Ting; Xu, Xiang
作者单位	1.Department of Stem Cell & Regenerative Medicine,State Key Laboratory of Trauma,Burn and Combined Injury,Daping Hospital,Army Medical University,Chongqing,400042,China; 2.Department of Dermatology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325035,China; 3.College of Sericulture,Textile and Biomass Sciences,Southwest University,Chongqing,400715,China
推荐引用方式 GB/T 7714	Wang, Xiao-Hui,Guo, Wei,Qiu, Wei,et al. Fibroblast-like cells Promote Wound Healing via PD-L1-mediated Inflammation Resolution[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES,2022,18(11):4388-4399.
APA	Wang, Xiao-Hui., Guo, Wei., Qiu, Wei., Ao, Luo-Quan., Yao, Meng-Wei., ... & Xu, Xiang. (2022). Fibroblast-like cells Promote Wound Healing via PD-L1-mediated Inflammation Resolution. INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, 18(11), 4388-4399.
MLA	Wang, Xiao-Hui,et al."Fibroblast-like cells Promote Wound Healing via PD-L1-mediated Inflammation Resolution".INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES 18.11(2022):4388-4399.