Non-invasive Liver Fibrosis Scores Are Associated With Recurrence of Postoperative Chronic Subdural Hematoma

doi:10.3389/fneur.2022.873124

科研成果详情

题名	Non-invasive Liver Fibrosis Scores Are Associated With Recurrence of Postoperative Chronic Subdural Hematoma
作者	Zhang, Peng1,2; Wang, Hua1,2; Bao, Han 1,2; Wang, Ning 3; Chen, Zhen1,2; Tu, Qi 1,2; Lin, Xiao1,2; Li, Yun1,2; Zheng, Zezheng1,2; Chen, Yu 1,2; Ruan, Linhui1,2; Zhuge, Qichuan1,2
发表日期	2022-06-13
发表期刊	FRONTIERS IN NEUROLOGY 影响因子和分区
语种	英语
原始文献类型	Article
关键词	chronic subdural hematoma liver fibrosis score recurrence risk factors aspartate aminotransferase alanine aminotransferase ratio fibrosis-4 forns index
其他关键词	DISEASE ; ELASTOGRAPHY ; COAGULOPATHY ; INFLAMMATION ; MANAGEMENT ; TESTS
摘要	ObjectiveAlthough liver diseases have already been identified as a risk factor for increased recurrence and mortality in patients with chronic subdural hematoma (CSDH), the association between subclinical liver disease, specifically liver fibrosis (LF), and CSDH remains unknown. In the present study, we aimed to investigate the association between the LF scores and CSDH recurrence. MethodsWe retrospectively analyzed consecutive patients with CSDH who underwent burr-hole irrigation in the First Affiliated Hospital of Wenzhou Medical University between January 2015 and December 2018. The clinical data were collected, and the LF scores were calculated including aspartate aminotransferase-platelet ratio index (APRI), fibrosis-4 (FIB-4), and Forns index. Multivariable logistic regression analysis was applied to identify the association between the LF scores and CSDH recurrence, and Cox regression model and Fine-Gray competing risks model were performed to calculate hazard ratios (HRs) for CSDH recurrence based on time-to-event outcomes. The C-statistic, the integrated discrimination improvement (IDI), and the net reclassification improvement (NRI) evaluated the additive value of the LF scores to predict the recurrence of CSDH. ResultsA total of 419 patients with CSDH were included, hematoma recurrence was observed in 62 patients (14.80%) within 1 year after surgery. The LF scores were significantly higher in those who recurred, whereas the standard hepatic assays were mostly normal. The patients were assigned to groups of high and low LF scores based on the validated cut-offs; compared with the subjects with low scores, those with high score levels had significantly higher recurrence rates. After adjusting for potential confounders, the LF scores were independently associated with CSDH recurrence, multivariable-adjusted HRs (95% CI) for those with higher levels of APRI, FIB-4, and Forns score were 4.32 (1.37-13.60), 2.56 (1.20-5.43), and 2.02 (1.07-3.79) for the recurrence of CSDH, respectively. Moreover, adding the APRI to the conventional model improved the C-statistic from 0.731 to 0.763, with an NRI and IDI of 7.50 and 1.35%, respectively. Two further commonly-used LF score indices (FIB-4 score and Forns index) yielded comparable results. ConclusionsThe data from this study first indicated that the high LF scores were significantly associated with the recurrence of CSDH and that careful follow-up in these patients may be needed.
资助项目	General Scientific Research Projects of Zhejiang Provincial Department of Education [Y202147811]
出版者	FRONTIERS MEDIA SA
出版地	LAUSANNE
ISSN	1664-2295
卷号	13 页码:873124
DOI	10.3389/fneur.2022.873124
页数	12
WOS类目	Clinical Neurology ; Neurosciences
WOS研究方向	Neurosciences & Neurology
WOS记录号	WOS:000816245100001
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	35769370
SCOPUSEID	2-s2.0-85133478075
通讯作者地址	[Ruan, Linhui]Department of Neurosurgery,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China ; [Zhuge, Qichuan]Department of Neurosurgery,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China
Scopus学科分类	Neurology;Neurology (clinical)
引用统计	被引频次[WOS]：0 [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/154526
专题	附属第一医院_神经外科第一临床医学院（信息与工程学院）、附属第一医院_老化与神经疾病重点实验室
通讯作者	Ruan, Linhui; Zhuge, Qichuan
作者单位	1.Department of Neurosurgery,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China; 2.Zhejiang Provincial Key Laboratory of Aging and Neurological Disorder Research,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China; 3.Neurointerventional Department,Zhejiang Hospital,Hangzhou,China
第一作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
通讯作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Zhang, Peng,Wang, Hua,Bao, Han,et al. Non-invasive Liver Fibrosis Scores Are Associated With Recurrence of Postoperative Chronic Subdural Hematoma[J]. FRONTIERS IN NEUROLOGY,2022,13:873124.
APA	Zhang, Peng., Wang, Hua., Bao, Han., Wang, Ning., Chen, Zhen., ... & Zhuge, Qichuan. (2022). Non-invasive Liver Fibrosis Scores Are Associated With Recurrence of Postoperative Chronic Subdural Hematoma. FRONTIERS IN NEUROLOGY, 13, 873124.
MLA	Zhang, Peng,et al."Non-invasive Liver Fibrosis Scores Are Associated With Recurrence of Postoperative Chronic Subdural Hematoma".FRONTIERS IN NEUROLOGY 13(2022):873124.