SARM1 deletion in parvalbumin neurons is associated with autism-like behaviors in mice

doi:10.1038/s41419-022-05083-2

科研成果详情

题名	SARM1 deletion in parvalbumin neurons is associated with autism-like behaviors in mice
作者	Xiang, Ludan 1,2; Wu, Qian1; Sun, Huankun1; Miao, Xuemeng 1; Lv, Zhaoting 1,2; Liu, Huitao3; Chen, Lan 1,4; Gu, Yanrou1; Chen, Jianjun1; Zhou, Siyao 1; Jiang, Huixia1; Du, Siyu1; Zhou, Yixin 1; Dong, Hui1; Fan, Yiren 1; Miao, Shuangda 1; Lu, Qi1; Chang, Liyun1; Wang, Hui 1; Lu, Yi1; Xu, Xingxing5; Wang, Wei1,6,7; Huang, Zhihui1,5,8
发表日期	2022-07-22
发表期刊	CELL DEATH & DISEASE 影响因子和分区
语种	英语
原始文献类型	Article
其他关键词	SPECTRUM DISORDER ; MOUSE MODEL ; NEUROINFLAMMATION ; REGULATOR ; DEFICITS ; NETWORK ; PROTEIN ; MEMORY
摘要	Autism spectrum disorder (ASD), a group of neurodevelopmental disorder diseases, is characterized by social deficits, communication difficulties, and repetitive behaviors. Sterile alpha and TIR motif-containing 1 protein (SARM1) is known as an autism-associated protein and is enriched in brain tissue. Moreover, SARM1 knockdown mice exhibit autism-like behaviors. However, its specific mechanism in ASD pathogenesis remains unclear. Here we generated parvalbumin-positive interneurons (PVI)-specific conditional SARM1 knockout (SARM1(PV)-CKO) mice. SARM1(PV)-CKO male mice showed autism-like behaviors, such as mild social interaction deficits and repetitive behaviors. Moreover, we found that the expression level of parvalbumin was reduced in SARM1(PV)-CKO male mice, together with upregulated apoptosis-related proteins and more cleaved-caspase-3-positive PVIs, suggesting that knocking out SARM1 may cause a reduction in the number of PVIs due to apoptosis. Furthermore, the expression of c-fos was shown to increase in SARM1(PV)-CKO male mice, in combination with upregulation of excitatory postsynaptic proteins such as PSD-95 or neuroligin-1, indicating enhanced excitatory synaptic input in mutant mice. This notion was further supported by the partial rescue of autism-like behavior deficits by the administration of GABA receptor agonists in SARM1(PV)-CKO male mice. In conclusion, our findings suggest that SARM1 deficiency in PVIs may be involved in the pathogenesis of ASD.
资助项目	National Natural Science Foundation of China [92049104, 31871042, 81971172]; Xinmiao Talents Program of Zhejiang Province, China [2021R413079]
出版者	SPRINGERNATURE
出版地	LONDON
ISSN	2041-4889
卷号	13 期号:7 页码:638
DOI	10.1038/s41419-022-05083-2
页数	11
WOS类目	Cell Biology
WOS研究方向	Cell Biology
WOS记录号	WOS:000829054000001
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	35869039
SCOPUSEID	2-s2.0-85134616293
通讯作者地址	[Wang, Wei]School of Mental Health,Wenzhou Medical University,Zhejiang,Wenzhou,325035,China ; [Huang, Zhihui]School of Mental Health,Wenzhou Medical University,Zhejiang,Wenzhou,325035,China
Scopus学科分类	Immunology;Cellular and Molecular Neuroscience;Cell Biology;Cancer Research
TOP期刊	TOP期刊
引用统计	被引频次：1[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/154365
专题	精神医学学院基础医学院（机能实验教学中心）第一临床医学院（信息与工程学院）、附属第一医院附属第一医院卓越中心_老年研究院其他_附属康宁医院（温州市康宁医院）
通讯作者	Wang, Wei; Huang, Zhihui
作者单位	1.School of Mental Health,Wenzhou Medical University,Zhejiang,Wenzhou,325035,China; 2.Tongde Hospital of Zhejiang Province,Zhejiang,Hangzhou,310012,China; 3.Department of Orthopedics (Spine Surgery),The First Affiliated Hospital of Wenzhou Medical University,Zhejiang,Wenzhou,325000,China; 4.Department of Child Psychiatry,Shaoxing Seventh People’s Hospital,Zhejiang,Shaoxing,312000,China; 5.School of Basic Medical Sciences,Wenzhou Medical University,Zhejiang,Wenzhou,325035,China; 6.Zhejiang Provincial Clinical Research Center for Mental Disorders,The Affiliated Wenzhou Kangning Hospital,Wenzhou Medical University,Zhejiang,Wenzhou,325000,China; 7.Institute of Aging,Key Laboratory of Alzheimer’s Disease of Zhejiang Province,Wenzhou Medical University,Zhejiang,Wenzhou,325035,China; 8.College of Pharmacy,Hangzhou Normal University,Zhejiang,Hangzhou,311121,China
第一作者单位	精神医学学院
通讯作者单位	精神医学学院
第一作者的第一单位	精神医学学院
推荐引用方式 GB/T 7714	Xiang, Ludan,Wu, Qian,Sun, Huankun,et al. SARM1 deletion in parvalbumin neurons is associated with autism-like behaviors in mice[J]. CELL DEATH & DISEASE,2022,13(7):638.
APA	Xiang, Ludan., Wu, Qian., Sun, Huankun., Miao, Xuemeng., Lv, Zhaoting., ... & Huang, Zhihui. (2022). SARM1 deletion in parvalbumin neurons is associated with autism-like behaviors in mice. CELL DEATH & DISEASE, 13(7), 638.
MLA	Xiang, Ludan,et al."SARM1 deletion in parvalbumin neurons is associated with autism-like behaviors in mice".CELL DEATH & DISEASE 13.7(2022):638.