Determinants of Diabetic Peripheral Neuropathy and Their Clinical Significance: A Retrospective Cohort Study

doi:10.3389/fendo.2022.934020

科研成果详情

题名	Determinants of Diabetic Peripheral Neuropathy and Their Clinical Significance: A Retrospective Cohort Study
作者	Cheng, Yifan 1; Cao, Wen 2; Zhang, Junzhe 3; Wang, Jiabin 4; Liu, Xiang 4; Wu, Qianqian 5; Lin, Qingxia6
发表日期	2022-07-26
发表期刊	FRONTIERS IN ENDOCRINOLOGY 影响因子和分区
语种	英语
原始文献类型	Article
关键词	type-2 diabetes mellitus diabetic peripheral neuropathy determinants clinical significance prevalence risk factor
其他关键词	MELLITUS ; PREVALENCE ; HYPERTENSION ; NEUTROPHILS ; IMPROVES ; HEALTH ; ROLES ; RATIO
摘要	BackgroundIn this study, we investigated the epidemiological characteristics and predictors of diabetic peripheral neuropathy (DPN) in adult patients with type 2 diabetes mellitus (DM). MethodsThe study was designed as a retrospective cohort trial at the First Affiliated Hospital of Wenzhou Medical University. From January 2017 to December 2020, a total of 1,262 patients with DM were enrolled to assess the risk factors for DPN. The patients were divided into two groups (DPN group and non-DPN group). The Mann-Whitney U test or t-test, receiver operating characteristic (ROC) analyses, univariate chi-square analyses, and multiple logistic regression analyses were used to analyze the adjusted predictors of DPN. ResultsThe overall prevalence of DPN in DM patients was 72.7% (n = 793/1,091). Multivariate analysis revealed that age > 66 years (odds ratio [OR], 2.647; 95% confidence interval [CI] 1.469-4.770; p = 0.002), history of hypertension (OR, 1.829; 95% CI 1.146-2.920; p = 0.011), neutrophil (NE) levels exceeding 4.0 x 10(9)/L (OR 0.256; 95% CI 0.162-0.405; p = 0.001), lymphocyte (LY) levels over 3.0 x 10(9)/L (OR 7.173; 95% CI 4.258-12.086; p = 0.000), HbA1c > 7.7% (OR 3.151; 95% CI 1.959-5.068; p = 0.000), and FT3 > 4.4 pmol/L (OR 0.417; 95% CI 0.263-0.662; p = 0.000) were six significant predictive factors for the prevalence of DPN. ConclusionsHigh levels of LY, HbA1c, history of hypertension, and > 66 years of age increase the risk of DPN in adult patients with DM, while high levels of NE and FT3 were protective factors of DPN. Thus, the prediction of DPN can significantly be improved by identifying older patients over the age of 66 and history of hypertension, as well as establishing the biochemical cutoff values of NE, LY, HbA1c, and FT3.
出版者	FRONTIERS MEDIA SA
出版地	LAUSANNE
ISSN	1664-2392
卷号	13 页码:934020
DOI	10.3389/fendo.2022.934020
页数	8
WOS类目	Endocrinology & Metabolism
WOS研究方向	Endocrinology & Metabolism
WOS记录号	WOS:000838216500001
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	35957831
SCOPUSEID	2-s2.0-85135605678
通讯作者地址	[Lin, Qingxia]Department of Psychiatry,First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China
Scopus学科分类	Endocrinology, Diabetes and Metabolism
引用统计	被引频次[WOS]：0 [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/154340
专题	其他_附属台州医院（浙江省台州医院）附属第一医院
通讯作者	Lin, Qingxia
作者单位	1.Department of Neurology,Center for Rehabilitation Medicine,Zhejiang Provincial People’s Hospital,Affiliated People’s Hospital,Hangzhou Medical College,Hangzhou,China; 2.Department of Neurology,The Third Hospital of Peking University,Beijing,China; 3.Department of Orthopaedic Surgery,The Third Hospital of Hebei Medical University,Shijiazhuang,China; 4.Department of Neurology,Hebei Medical University,Shijiazhuang,China; 5.Department of Geriatrics,Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University,Taizhou,China; 6.Department of Psychiatry,First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China
通讯作者单位	附属第一医院
推荐引用方式 GB/T 7714	Cheng, Yifan,Cao, Wen,Zhang, Junzhe,et al. Determinants of Diabetic Peripheral Neuropathy and Their Clinical Significance: A Retrospective Cohort Study[J]. FRONTIERS IN ENDOCRINOLOGY,2022,13:934020.
APA	Cheng, Yifan., Cao, Wen., Zhang, Junzhe., Wang, Jiabin., Liu, Xiang., ... & Lin, Qingxia. (2022). Determinants of Diabetic Peripheral Neuropathy and Their Clinical Significance: A Retrospective Cohort Study. FRONTIERS IN ENDOCRINOLOGY, 13, 934020.
MLA	Cheng, Yifan,et al."Determinants of Diabetic Peripheral Neuropathy and Their Clinical Significance: A Retrospective Cohort Study".FRONTIERS IN ENDOCRINOLOGY 13(2022):934020.