Lower serum copper concentrations are associated with higher prevalence of nonalcoholic steatohepatitis: a matched case-control study

doi:10.1097/MEG.0000000000002392

科研成果详情

题名	Lower serum copper concentrations are associated with higher prevalence of nonalcoholic steatohepatitis: a matched case-control study
作者	Zhang, Huai1,2; Zheng, Kenneth I.2; Zhu, Pei-Wu 3; Chen, Sui-Dan4; Li, Gang2; Ma, Hong-Lei 2; Tang, Liang-Jie 2; Huang, Ou-Yang2; Byrne, Christopher D.5; Targher, Giovanni 6; Wang, Xiao-Dong 7; Zheng, Ming-Hua2,7,8
发表日期	2022-08
发表期刊	EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY 影响因子和分区
语种	英语
原始文献类型	Article
关键词	case-control liver biopsy metabolic (dysfunction) associated fatty liver disease nonalcoholic fatty liver disease nonalcoholic steatohepatitis serum copper
其他关键词	FATTY LIVER-DISEASE ; AMPK
摘要	Background and aim Copper is an essential trace element involved in oxidative stress reactions and energy metabolism. While nonalcoholic fatty liver disease (NAFLD) is closely related to metabolic dysfunction, the role of copper in the development of simple steatosis (NAFL) and nonalcoholic steatohepatitis (NASH) is still unclear. We aimed to compare serum copper levels between patients with simple steatosis and those with NASH. Methods and results We studied 102 patients with biopsy-proven NASH (cases) and 102 NAFL controls, who were matched for age, sex, and residential city. Multivariable conditional logistic analysis was performed to explore associations between serum copper levels and the presence of NASH. Serum copper levels were significantly lower in patients with NASH than in those with matched NAFL controls (15.53 +/- 2.41 mu mol/l vs. 16.34 +/- 3.23 mu mol/l; P = 0.029). This intergroup difference in serum copper levels was more pronounced in men than in women. The per unit, per SD, and per doubling of serum copper levels were associated, respectively, with an approximately 20, 40, and 90% decrease in risk of having NASH, even after adjustment for potential confounding factors. Conclusion Lower serum copper concentrations are significantly associated with higher prevalence of NASH among biopsied-proven NAFLD patients, particularly in men.
资助项目	National Natural Science Foundation of China [82070588]; HighLevel Creative Talents from the Department of Public Health in Zhejiang Province [S2032102600032]; Project of New Century 551 Talent Nurturing in Wenzhou; University School of Medicine of Verona, Verona, Italy; Southampton NIHR Biomedical Research Centre, UK [IS-BRC-20004]
出版者	LIPPINCOTT WILLIAMS & WILKINS
出版地	PHILADELPHIA
ISSN	0954-691X
EISSN	1473-5687
卷号	34 期号:8 页码:838-843
DOI	10.1097/MEG.0000000000002392
页数	6
WOS类目	Gastroenterology & Hepatology
WOS研究方向	Gastroenterology & Hepatology
WOS记录号	WOS:000822069100004
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	35694803
SCOPUSEID	2-s2.0-85134323653
通讯作者地址	[Zheng, Ming-Hua]NAFLD Research Center,Department of Hepatology,The First Affiliated Hospital of Wenzhou Medical University,No. 2 Fuxue Lane,Wenzhou,325000,China
Scopus学科分类	Hepatology;Gastroenterology
引用统计	被引频次[WOS]：0 [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/154314
专题	附属第一医院第一临床医学院（信息与工程学院）、附属第一医院_浙江省胰脏肝脏危重性疾病重点实验室
通讯作者	Zheng, Ming-Hua
作者单位	1.Biostatistics and Medical Quality Management Office,The First Affiliated Hospital of Wenzhou Medical University,China; 2.NAFLD Research Center,Department of Hepatology,The First Affiliated Hospital of Wenzhou Medical University,No. 2 Fuxue Lane,Wenzhou,325000,China; 3.Departments of Clinical Laboratory,China; 4.Departments of Pathology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China; 5.Southampton National Institute for Health Research,Biomedical Research Centre,University Hospital Southampton,Southampton General Hospital,Southampton,United Kingdom; 6.Section of Endocrinology,Diabetes and Metabolism,Department of Medicine,University and Azienda Ospedaliera,Universitaria Integrata of Verona,Verona,Italy; 7.Key Lab. of Diagn. and Treatment for the Development of Chronic Liver Disease in Zhejiang Province,China; 8.Institute of Hepatology,Wenzhou Medical University,Wenzhou,China
第一作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
通讯作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Zhang, Huai,Zheng, Kenneth I.,Zhu, Pei-Wu,et al. Lower serum copper concentrations are associated with higher prevalence of nonalcoholic steatohepatitis: a matched case-control study[J]. EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY,2022,34(8):838-843.
APA	Zhang, Huai., Zheng, Kenneth I.., Zhu, Pei-Wu., Chen, Sui-Dan., Li, Gang., ... & Zheng, Ming-Hua. (2022). Lower serum copper concentrations are associated with higher prevalence of nonalcoholic steatohepatitis: a matched case-control study. EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, 34(8), 838-843.
MLA	Zhang, Huai,et al."Lower serum copper concentrations are associated with higher prevalence of nonalcoholic steatohepatitis: a matched case-control study".EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY 34.8(2022):838-843.