Prediction of BRAF mutation status in glioblastoma multiforme by preoperative ring enhancement appearances on MRI

doi:10.3389/fonc.2022.937345

科研成果详情

题名	Prediction of BRAF mutation status in glioblastoma multiforme by preoperative ring enhancement appearances on MRI
作者	Cai, Xiaomin 1; Chen, Zheng 1; Chang, Bowen 2; Tu, Ming3; Li, Shiting 4; Wang, Xuhui 4,5; Chen, Ming 1
发表日期	2022-08-08
发表期刊	FRONTIERS IN ONCOLOGY 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Glioblastoma multiforme BRAF Ring enhancement MRI Nomogram
其他关键词	CENTRAL-NERVOUS-SYSTEM ; EPITHELIOID GLIOBLASTOMAS ; ADJUVANT TEMOZOLOMIDE ; CLASSIFICATION ; TUMORS ; RADIOTHERAPY ; CONCOMITANT ; DABRAFENIB ; RECURRENT ; THERAPY
摘要	BackgroundRing enhancement on magnetic resonance imaging (MRI) is an important characteristic of GBM. Though patients suffering from glioblastoma multiforme (GBM) with BRAF mutation (MUT BRAF) in V600E benefit from BRAF-targeted inhibitors, the relationship between ring enhancement and MUT BRAF remains elusive. The purpose of this study was to investigate the relationship between BRAF mutation status and the appearance of ring enhancement so as to guide preoperative targeted therapy for MUT BRAF GBM. MethodsPatient's population, clinical data and characteristic ring enhancement appearances on MRI were compared between GBM with MUT BRAF and GBM with WT BRAF. A receiver operating characteristic (ROC) curve analysis was performed to evaluate the differential diagnostic significance. A nomogram was developed to predict the mutation status of BRAF. Moreover, all the variables were re-analyzed between epithelioid GBM (E-GBM) with or without MUT BRAF. ResultsCompared to GBM with WT BRAF, GBM with MUT BRAF had specific ring enhancement appearances with multiple rings, multiple located lobes, regular shape of ring, uniform thickness of ring and smaller diameter of ring. Area under the curve (AUC) of all the variables' combination was 0.929. The nomogram was developed and validated. The re-analyzed results between E-GBM with or without MUT BRAF were similar to these above. AUC of the combination of quantity of ring, quantity of located lobe and shape of ring was 0.962. ConclusionThe characteristic ring enhancement appearances of GBM may play an important role in predicting BRAF mutation status preoperatively, especially in E-GBM. Further study with larger cases may provide more evidences to guide the pretreatment of targeted medicine for GBM patients with MUT BRAF in future.
资助项目	National Natural Science Foundation of China; Shanghai Sailing Program; Research Project of Xinhua Hospital; Doctoral Research Fund of the First Affiliated Hospital of USTC; WenZhou Science and Technology Bureau Project; [81902521]; [19YF1432800]; [XH1936]; [RC2021121]; [Y20190143]
出版者	FRONTIERS MEDIA SA
出版地	LAUSANNE
ISSN	2234-943X
卷号	12 页码:937345
DOI	10.3389/fonc.2022.937345
页数	12
WOS类目	Oncology
WOS研究方向	Oncology
WOS记录号	WOS:000843373300001
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
Pubmed记录号	36003762
Scopus记录号	2-s2.0-85136479088
通讯作者地址	[Chen, Ming]Department of Neurosurgery,Xinhua Hospital of Shanghai Jiaotong University School of Medicine,Shanghai,China ; [Li, Shiting]Department of Neurosurgery,Xinhua Hospital of Shanghai Jiaotong University School of Medicine,the Cranial Nerve Disease Center of Shanghai Jiaotong University,Shanghai,China ; [Wang, Xuhui]Department of Neurosurgery,Xinhua Hospital of Shanghai Jiaotong University School of Medicine,Cranial Nerve Disease Center of Shanghai,Jiaotong University,Shanghai,China
scopus学科分类	Oncology;Cancer Research
引用统计	被引频次[WOS]：0 [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/154255
专题	附属第一医院_神经外科
通讯作者	Li, Shiting; Wang, Xuhui; Chen, Ming
作者单位	1.Department of Neurosurgery,Xinhua Hospital of Shanghai Jiaotong University School of Medicine,Shanghai,China; 2.Department of Neurosurgery,The First Affiliated Hospital of USTC,Division of Life Sciences and Medicine,University of Science and Technology of China,Hefei,China; 3.Department of Neurosurgery,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China; 4.Department of Neurosurgery,Xinhua Hospital of Shanghai Jiaotong University School of Medicine,Cranial Nerve Disease Center of Shanghai,Jiaotong University,Shanghai,China; 5.Department of Neurosurgery,Xinhua Hospital of Shanghai Jiaotong University School of Medicine,Chongming Branch,Shanghai,China
推荐引用方式 GB/T 7714	Cai, Xiaomin,Chen, Zheng,Chang, Bowen,et al. Prediction of BRAF mutation status in glioblastoma multiforme by preoperative ring enhancement appearances on MRI[J]. FRONTIERS IN ONCOLOGY,2022,12:937345.
APA	Cai, Xiaomin., Chen, Zheng., Chang, Bowen., Tu, Ming., Li, Shiting., ... & Chen, Ming. (2022). Prediction of BRAF mutation status in glioblastoma multiforme by preoperative ring enhancement appearances on MRI. FRONTIERS IN ONCOLOGY, 12, 937345.
MLA	Cai, Xiaomin,et al."Prediction of BRAF mutation status in glioblastoma multiforme by preoperative ring enhancement appearances on MRI".FRONTIERS IN ONCOLOGY 12(2022):937345.