An injectable liposome for sustained release of icariin to the treatment of acute blunt muscle injury

doi:10.1111/jphp.13314

科研成果详情

题名	An injectable liposome for sustained release of icariin to the treatment of acute blunt muscle injury
作者	Wang, Jinwu 1,2; Zhu, Gaosheng 1,2; Wang, Xingyu 1,2; Cai, Jie 1,2; Xie, Linzhen 1,2; Zheng, Wenhao1,2; Feng, Yongzeng1,2; Guo, Qiang1,2; Chen, Hua1,2; Cai, Leyi1,2
发表日期	2020-09
发表期刊	JOURNAL OF PHARMACY AND PHARMACOLOGY 影响因子和分区
语种	英语
原始文献类型	Article
关键词	icariin icariin liposome liposome muscle injury
其他关键词	ISCHEMIA/REPERFUSION INJURY ; SKELETAL-MUSCLE ; IN-VITRO ; PHARMACOKINETICS ; ATHEROSCLEROSIS ; REGENERATION ; EPIMEDIUM ; RECOVERY ; COLLAGEN ; RATS
摘要	Objectives Icariin, extracted from Epimedium, is a kind of flavonoid and possesses osteogenesis and antioxidant. This study aimed to evaluate the therapeutic effects of icariin liposome on acute blunt skeletal muscle injury in rats. Methods Icariin liposome was prepared by the thin-film dispersion method. After muscle injury, the corresponding treatment measures were given every day for two weeks. Recovery and mechanism of muscle injury were evaluated by QRT-PCR, HE, immunohistochemistry, malondialdehyde, superoxide dismutase and serological tests. Key findings The particle size, polydispersity index, zeta potential, encapsulation efficiency and drug loading of icariin liposomes were 171.37 +/- 38.23 nm, 0.27 +/- 0.01, -5.59 +/- 1.36 mV, 78.15 +/- 2.04% and 15.62%, respectively. The QRT-PCR showed that icariin liposome significantly promoted the expression of MHCIIB and vimentin. Through HE, immunohistochemistry, ELISA and serological tests, we found that icariin liposome effectively promoted desmin expression, reduced collagen I expression and inhibited the production of pro-inflammatory factors, including TNF-alpha and IL-6. Icariin liposome therapy significantly reduced the level of malondialdehyde and increased the activity of superoxide dismutase. Conclusions Icariin liposome has excellent therapeutic effects on acute blunt muscle injury in rats by improving immunity, repairing cytoskeleton and cellular integrity, anti-inflammation, anti-fibrosis and antioxidant stress.
资助项目	National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81701928]; Zhejiang Medical and Health Science and Technology Plan Project [2017KY480]
出版者	WILEY
出版地	HOBOKEN
ISSN	0022-3573
EISSN	2042-7158
卷号	72 期号:9 页码:1152-1164
DOI	10.1111/jphp.13314
页数	13
WOS类目	Pharmacology & Pharmacy
WOS研究方向	Pharmacology & Pharmacy
WOS记录号	WOS:000541540900001
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	32567690
SCOPUSEID	2-s2.0-85087315580
通讯作者地址	[Cai, Leyi]Department of Orthopaedics,Wenzhou Medical University Second Affiliated Hospital,Wenzhou,China ; [Cai, Leyi]Wenzhou Medical University,Wenzhou,China
Scopus学科分类	Medicine (all)
引用统计	被引频次：1[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/1541
专题	附属第二医院温州医科大学
通讯作者	Cai, Leyi
作者单位	1.Department of Orthopaedics,Wenzhou Medical University Second Affiliated Hospital,Wenzhou,China; 2.Wenzhou Medical University,Wenzhou,China
第一作者单位	附属第二医院; 温州医科大学
通讯作者单位	附属第二医院; 温州医科大学
第一作者的第一单位	附属第二医院
推荐引用方式 GB/T 7714	Wang, Jinwu,Zhu, Gaosheng,Wang, Xingyu,et al. An injectable liposome for sustained release of icariin to the treatment of acute blunt muscle injury[J]. JOURNAL OF PHARMACY AND PHARMACOLOGY,2020,72(9):1152-1164.
APA	Wang, Jinwu., Zhu, Gaosheng., Wang, Xingyu., Cai, Jie., Xie, Linzhen., ... & Cai, Leyi. (2020). An injectable liposome for sustained release of icariin to the treatment of acute blunt muscle injury. JOURNAL OF PHARMACY AND PHARMACOLOGY, 72(9), 1152-1164.
MLA	Wang, Jinwu,et al."An injectable liposome for sustained release of icariin to the treatment of acute blunt muscle injury".JOURNAL OF PHARMACY AND PHARMACOLOGY 72.9(2020):1152-1164.