The characteristic and osteogenic effect of a nanoporous coating of zirconia implant

doi:10.1016/j.ceramint.2022.06.135

科研成果详情

题名	The characteristic and osteogenic effect of a nanoporous coating of zirconia implant
作者	Li, Li 1; Yao, Litao 1; Wu, Lianjun2; Ma, Qingfang 1; Jiang, Jing 4; Lin, Shiyu 3; Shen, Xufei 5; Huang, Chengyi 1; Sheng, Lieping 1
发表日期	2022-09-01
发表期刊	Ceramics International 影响因子和分区
语种	英语
原始文献类型	Journal article (JA)
关键词	Biocompatibility Biomechanics Bond strength (materials) Bone Chemical analysis Coatings Dental prostheses Hydrophilicity Morphology Anodizations Dental implant materials Nano layers Nano-porous Nano-porous coatings Osteogenic Osteogenic effects Surface-modification Zirconia ceramic Zirconium implant
其他关键词	SURFACE-TOPOGRAPHY ; TITANIUM ; BONE ; CELLS ; OXIDE
摘要	Zirconia ceramics have become increasingly used as dental implant material which is mainly due to their "tooth-like" color, superior biocompatibility, and excellent mechanical properties. However, the bio-inertness of the zirconia surface limits its use for a wider range of clinical applications. To enhance the surface bioactivity, a combination of magnetron sputtering, and anodization has in the present study been used to deposit a homogeneous nano-porous coating (ZrNP) on the zirconia surface (forming ZrO2/ZrNP with a ZrNP pore diameter of 20–30 nm, and a ZrNP layer thickness of ∼2 μm). EDS and XRD analysis showed that the distribution of the surface chemical components, as well as the crystalline structure of the zirconia (ZrO2), remained unchanged. On the other hand, the hydrophilicity of the ZrO2/ZrNP surface became significantly improved (as compared with a control group). In addition, the bond strength of the coating was decreased as a result of the anodization treatment. Moreover, both the Zr and ZrNP nanolayers exhibited improved proliferation and osteogenic properties in the in vitro cell experiment. Also, the ZrNP nanolayer was found to promote the biocompatibility and osteogenic ability to the largest extent. The ZrNP nanolayer did also provide numerous adhesion sites for MC3T3-E1 whereby the cell morphology could be enhanced. Additionally, the nano porous ZrNP layer improved the new bone formation around the zirconia implant and did robustly enhance the push out bond strength, thereby indicating the best osteointegration ability. In conclusion, a nano porous zirconium layer has been found to be very promising for the improvement of the bioactivity of the zirconia implant material. © 2022
资助项目	Natural Science Foundation of Zhejiang Province [Y15H140003]; Education and Teaching Reform Project of Wenzhou Medical University [JG2021099]; Wenzhou Municipal Science and Technology Project for Public Welfare [Y20190488]
出版者	Elsevier Ltd
ISSN	0272-8842
EISSN	-
卷号	48 期号:17 页码:24260-24267
DOI	10.1016/j.ceramint.2022.06.135
页数	8
WOS类目	Materials Science, Ceramics
WOS研究方向	Materials Science
WOS记录号	WOS:000833899800001
收录类别	EI ; SCIE ; SCOPUS
EI入藏号	20222612275828
EI主题词	Zirconia
EI分类号	461.2 Biological Materials and Tissue Engineering ; 461.3 Biomechanics, Bionics and Biomimetics ; 461.9.1 Immunology ; 462.3 Dental Equipment and Supplies ; 804.2 Inorganic Compounds ; 813.2 Coating Materials ; 931.2 Physical Properties of Gases, Liquids and Solids ; 951 Materials Science
URL	查看原文
SCOPUSEID	2-s2.0-85132693951
通讯作者地址	[Huang, Chengyi]null ; [Sheng, Lieping]null
Scopus学科分类	Electronic, Optical and Magnetic Materials;Ceramics and Composites;Process Chemistry and Technology;Surfaces, Coatings and Films;Materials Chemistry
TOP期刊	TOP期刊
引用统计	被引频次[WOS]：0 [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/153407
专题	口腔医学院、附属口腔医院
通讯作者	Huang, Chengyi; Sheng, Lieping
作者单位	1.Department of Dentistry,Sir Run Run Shaw Hospital,School of Medicine,Zhejiang University,Hangzhou,Hangzhou,310058,China; 2.School and Hospital of Stomatology,Wenzhou Medical University,Wenzhou,325027,China; 3.The Affiliated Hospital of Stomatology,School of Stomatology,Zhejiang University School of Medicine,Key Laboratory of Oral Biomedical Research of Zhejiang Province,Hangzhou,Hangzhou,310006,China; 4.SuiChang Traditional Chinese Medicine Hospital,Suichang,Suichang,China; 5.Deqing Campus,Sir Run Run Shaw Hospital,School of Medicine,Zhejiang University,Hangzhou,Hangzhou,China
推荐引用方式 GB/T 7714	Li, Li,Yao, Litao,Wu, Lianjun,et al. The characteristic and osteogenic effect of a nanoporous coating of zirconia implant[J]. Ceramics International,2022,48(17):24260-24267.
APA	Li, Li., Yao, Litao., Wu, Lianjun., Ma, Qingfang., Jiang, Jing., ... & Sheng, Lieping. (2022). The characteristic and osteogenic effect of a nanoporous coating of zirconia implant. Ceramics International, 48(17), 24260-24267.
MLA	Li, Li,et al."The characteristic and osteogenic effect of a nanoporous coating of zirconia implant".Ceramics International 48.17(2022):24260-24267.