The DDR-related gene signature with cell cycle checkpoint function predicts prognosis, immune activity, and chemoradiotherapy response in lung adenocarcinoma

doi:10.1186/s12931-022-02110-w

科研成果详情

题名	The DDR-related gene signature with cell cycle checkpoint function predicts prognosis, immune activity, and chemoradiotherapy response in lung adenocarcinoma
作者	Li, Quan1,2,3,5; Zhang, Pan1,2,3,5; Hu, Huixiao1,2,3,5; Huang, Hang1,2,3,5; Pan, Dong 4; Mao, Guangyun5; Hu, Burong1,2,3
发表日期	2022-07-15
发表期刊	RESPIRATORY RESEARCH 影响因子和分区
语种	英语
原始文献类型	Article
关键词	POLO-LIKE KINASES CANCER EXPRESSION ASSOCIATION METHYLATION
其他关键词	POLO-LIKE KINASES ; CANCER ; EXPRESSION ; ASSOCIATION ; METHYLATION ; INHIBITION ; RESISTANCE ; APOPTOSIS ; TARGETS ; REPAIR
摘要	Background: As a DNA surveillance mechanism, cell cycle checkpoint has recently been discovered to be closely associated with lung adenocarcinoma (LUAD) prognosis. It is also an essential link in the process of DNA damage repair (DDR) that confers resistance to radiotherapy. Whether genes that have both functions play a more crucial role in LUAD prognosis remains unclear. Methods: In this study, DDR-related genes with cell cycle checkpoint function (DCGs) were selected to investigate their effects on the prognosis of LUAD. The TCGA-LUAD cohort and two GEO external validation cohorts (GSE31210 and GSE42171) were performed to construct a prognosis model based on the least absolute shrinkage and selection operator (LASSO) regression. Patients were divided into high-risk and low-risk groups based on the model. Subsequently, the multivariate COX regression was used to construct a prognostic nomogram. The ssGSEA, CIBERSORT algorithm, TIMER tool, CMap database, and IC50 of chemotherapeutic agents were used to analyze immune activity and responsiveness to chemoradiotherapy. Results: 4 DCGs were selected as prognostic signatures, and patients in the high-risk group had a lower overall survival (OS).The lower infiltration levels of immune cells and the higher expression levels of immune checkpoints appeared in the high-risk group. The damage repair pathways were upregulated, and chemotherapeutic agent sensitivity was poor in the high-risk group. Conclusions: The 4-DCGs signature prognosis model we constructed could predict the survival rate, immune activity, and chemoradiotherapy responsiveness of LUAD patients.
资助项目	Scientific Research Project of Wenzhou Medical University for Talent [QTJ20010]; National Natural Science Foundation of China [11635013]
出版者	BMC
出版地	LONDON
ISSN	1465-993X
EISSN	1465-993X
卷号	23 期号:1 页码:190
DOI	10.1186/s12931-022-02110-w
页数	17
WOS类目	Respiratory System
WOS研究方向	Respiratory System
WOS记录号	WOS:000826047400003
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
发表状态	已发表
Pubmed记录号	35840978
Scopus记录号	2-s2.0-85134236334
通讯作者地址	[Hu, Burong]Department of Radiation Medicine,School of Public Health and Management,Wenzhou Medical University,Wenzhou,325035,China
scopus学科分类	Pulmonary and Respiratory Medicine
引用统计	被引频次[WOS]：0 [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/153370
专题	公共卫生与管理学院_放射卫生与放射医学系公共卫生与管理学院_预防医学系
通讯作者	Hu, Burong
作者单位	1.Department of Radiation Medicine,School of Public Health and Management,Wenzhou Medical University,Wenzhou,325035,China; 2.Zhejiang Provincial Key Laboratory of Watershed Sciences and Health,Wenzhou Medical University,Wenzhou,325035,China; 3.South Zhejiang Institute of Radiation Medicine and Nuclear Technology,Wenzhou Medical University,Wenzhou,325035,China; 4.Department of Dermatology,Duke University Medical Center,Durham,27710,United States; 5.Department of Preventive Medicine,School of Public Health and Management,Wenzhou Medical University,Wenzhou,325035,China
第一作者单位	公共卫生学院; 温州医科大学; 预防医学系
通讯作者单位	公共卫生学院
第一作者的第一单位	公共卫生学院
推荐引用方式 GB/T 7714	Li, Quan,Zhang, Pan,Hu, Huixiao,et al. The DDR-related gene signature with cell cycle checkpoint function predicts prognosis, immune activity, and chemoradiotherapy response in lung adenocarcinoma[J]. RESPIRATORY RESEARCH,2022,23(1):190.
APA	Li, Quan., Zhang, Pan., Hu, Huixiao., Huang, Hang., Pan, Dong., ... & Hu, Burong. (2022). The DDR-related gene signature with cell cycle checkpoint function predicts prognosis, immune activity, and chemoradiotherapy response in lung adenocarcinoma. RESPIRATORY RESEARCH, 23(1), 190.
MLA	Li, Quan,et al."The DDR-related gene signature with cell cycle checkpoint function predicts prognosis, immune activity, and chemoradiotherapy response in lung adenocarcinoma".RESPIRATORY RESEARCH 23.1(2022):190.

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