Efficacy of Infliximab in a Rabbit Model of Osteoarthritis

doi:10.3109/03008207.2012.661001

科研成果详情

题名	Efficacy of Infliximab in a Rabbit Model of Osteoarthritis
作者	Zhang, Qiankun 1; Lv, Hong Hua 1; Chen, Aqiong 2; Liu, Feijun 3; Wu, Xuelian 1
发表日期	2012-12-31
发表期刊	CONNECTIVE TISSUE RESEARCH 影响因子和分区
语种	英语
原始文献类型	Article
关键词	infliximab intra-articular injection osteoarthritis rabbit model TNF
其他关键词	NITRIC-OXIDE ; CYTOKINES ; METALLOPROTEINASES ; KNEE
摘要	The purpose of this study was to investigate the efficacy of intra-articular injection of infliximab in a rabbit model of osteoarthritis. In 30 New Zealand white rabbits, the cruciate ligaments and medial menisci were resected using the Hulth technique. Eight weeks postsurgery, the animals were randomly divided into three groups, and each group was given monthly intra-articular injections (0.5 ml) of 10 mg/ml infliximab, 20 mg/ml infliximab, or saline, respectively. After 3 months, the results were assessed by macroscopic observation, histological evaluation, and measurement of the levels of interleukin-1 beta, tumor necrosis factor-a, and nitric oxide in the synovial fluid. In the two groups of rabbits administered infliximab (10 or 20 mg/ml), the pathological changes were more attenuated than in the group administered saline. Mankin scores in the rabbits administered infliximab 10 mg/ml (2.7 +/- 0.9) or infliximab 20 mg/ml (2.4 +/- 0.7) were significantly lower than in the control group (6.4 +/- 1.2) (p < 0.05). The tumor necrosis factor-a and nitric oxide contents of the synovial fluid were also decreased significantly in the rabbits administered infliximab at both concentrations compared with the saline-injected rabbits (p < 0.05). Administration of infliximab did not change the levels of interleukin-1 beta in the synovial fluid. Similar results were obtained for all analyses with the two concentrations of infliximab tested. This study demonstrates that intra-articular injections of infliximab can protect against the development of experimentally induced osteoarthritis.
出版者	TAYLOR & FRANCIS INC
出版地	PHILADELPHIA
ISSN	0300-8207
EISSN	1607-8438
卷号	53 期号:5 页码:355-358
DOI	10.3109/03008207.2012.661001
页数	4
WOS类目	Cell Biology ; Orthopedics
WOS研究方向	Cell Biology ; Orthopedics
WOS记录号	WOS:000308424100003
收录类别	SCIE
PubMed ID	22288847
通讯作者地址	[Zhang, Qiankun]Lishui Ctr Hosp, Dept Rheumatol, Lishui 323000, Zhejiang, Peoples R China.
引用统计	被引频次：15[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/15291
专题	附属第一医院_风湿免疫科
通讯作者	Zhang, Qiankun
作者单位	1.Lishui Ctr Hosp, Dept Rheumatol, Lishui 323000, Zhejiang, Peoples R China; 2.Wenzhou Med Coll, Dept Rheumatol, Affiliated Hosp 1, Wenzhou, Peoples R China; 3.Lishui Ctr Hosp, Dept Orthopaed Surg, Lishui 323000, Zhejiang, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Qiankun,Lv, Hong Hua,Chen, Aqiong,et al. Efficacy of Infliximab in a Rabbit Model of Osteoarthritis[J]. CONNECTIVE TISSUE RESEARCH,2012,53(5):355-358.
APA	Zhang, Qiankun, Lv, Hong Hua, Chen, Aqiong, Liu, Feijun, & Wu, Xuelian. (2012). Efficacy of Infliximab in a Rabbit Model of Osteoarthritis. CONNECTIVE TISSUE RESEARCH, 53(5), 355-358.
MLA	Zhang, Qiankun,et al."Efficacy of Infliximab in a Rabbit Model of Osteoarthritis".CONNECTIVE TISSUE RESEARCH 53.5(2012):355-358.