Effect of Abiraterone on Pharmacokinetics of Cabozantinib in Rats by UPLC-MS/MS

科研成果详情

题名	Effect of Abiraterone on Pharmacokinetics of Cabozantinib in Rats by UPLC-MS/MS
作者	Zheng, Yuancai1; Lu, Xiaojie2; Huang, Bingge 2; Zhong, Zuoquan2; Zhou, Quan 3
发表日期	2019
发表期刊	LATIN AMERICAN JOURNAL OF PHARMACY 影响因子和分区
语种	英语
原始文献类型	Article
关键词	abiraterone cabozantinib pharmacokinetic rat interaction
其他关键词	PROSTATE-CANCER ; DIAGNOSTIC PERFORMANCE ; TISSUE DISTRIBUTION ; PLASMA ; CYP450 ; MODEL
摘要	This study examined whether oral administration of abiraterone to rats with cabozantinib led to any cabozantinib pharmacokinetic interactions. Sixteen rats were divided randomly into 2 groups, cabozantinib group (cabozantinib 30 mg/kg, n = 8), and co-administration group (abiraterone 50 mg/kg and cabozantinib30 mg/kg, n = 8). The concentration of cabozantinib in rat plasma was determined by a sensitive and simple UPLC-MS-MS method. The linear regressions of the peak area ratios versus concentrations were fitted over the concentration range 5-5000 ng/mL for cabozantinib in rat plasma. The recovery for cabozantinib were between 85.0 and 93.0%, the matrix effect were between 96.9 and 104.8% (n = 6). The precision (RSD) were both less than 12%, and the accuracy were between 92.1 and 106.9% (n = 6). There was no statistical pharmacokinetics difference for cabozantinib in the cabozantinib group and co-administration group, the abiraterone could not influence the pharmacokinetic profile of cabozantinib in rats.
资助项目	Wenzhou Science and Technology Bureau Project [Y20160333]
出版者	COLEGIO FARMACEUTICOS PROVINCIA DE BUENOS AIRES
出版地	LA PLATA
ISSN	0326-2383
卷号	38 期号:3 页码:553-557
页数	5
WOS类目	Pharmacology & Pharmacy
WOS研究方向	Pharmacology & Pharmacy
WOS记录号	WOS:000463830000020
收录类别	SCIE ; SCOPUS
URL	查看原文
SCOPUSEID	2-s2.0-85064336210
通讯作者地址	[Zhou, Quan]The Laboratory of Clinical Pharmacy,People’s Hospital of Lishui City,Lishui,323000,China
Scopus学科分类	Pharmaceutical Science;Drug Discovery
引用统计	被引频次[WOS]：0 [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/15153
专题	附属第一医院实验动物中心
通讯作者	Zhou, Quan
作者单位	1.The First Affiliated Hospital,Wenzhou Medical University,Wenzhou,325035,China; 2.Laboratory Animal Centre,Wenzhou Medical University,Wenzhou,325035,China; 3.The Laboratory of Clinical Pharmacy,People’s Hospital of Lishui City,Lishui,323000,China
第一作者单位	附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Zheng, Yuancai,Lu, Xiaojie,Huang, Bingge,et al. Effect of Abiraterone on Pharmacokinetics of Cabozantinib in Rats by UPLC-MS/MS[J]. LATIN AMERICAN JOURNAL OF PHARMACY,2019,38(3):553-557.
APA	Zheng, Yuancai, Lu, Xiaojie, Huang, Bingge, Zhong, Zuoquan, & Zhou, Quan. (2019). Effect of Abiraterone on Pharmacokinetics of Cabozantinib in Rats by UPLC-MS/MS. LATIN AMERICAN JOURNAL OF PHARMACY, 38(3), 553-557.
MLA	Zheng, Yuancai,et al."Effect of Abiraterone on Pharmacokinetics of Cabozantinib in Rats by UPLC-MS/MS".LATIN AMERICAN JOURNAL OF PHARMACY 38.3(2019):553-557.