Metabolic Syndrome-Related Hyperuricemia is Associated with a Poorer Prognosis in Patients with Colorectal Cancer: A Multicenter Retrospective Study

doi:10.2147/CMAR.S338783

科研成果详情

题名	Metabolic Syndrome-Related Hyperuricemia is Associated with a Poorer Prognosis in Patients with Colorectal Cancer: A Multicenter Retrospective Study
作者	Feng, Qian 1; Tang, Liang-Jie 2; Luo, Ding-Hai 3; Wang, Ying 1; Wu, Nan 1; Chen, Hao1; Chen, Meng-Xia1; Jiang, Lei4; Jin, Rong1,5
发表日期	2021
发表期刊	CANCER MANAGEMENT AND RESEARCH 影响因子和分区
语种	英语
原始文献类型	Article
关键词	colorectal cancer metabolic syndrome hyperuricemia prognosis
其他关键词	SERUM URIC-ACID ; GASTRIC-CANCER ; BLOOD-PRESSURE ; RISK-FACTOR ; STATISTICS ; COMPONENTS ; MORTALITY ; PREDICT ; ADULTS ; CHINA
摘要	Purpose: Hyperuricemia and metabolic syndrome (MetS) have been shown to correlate with prognosis in patients with malignant tumors. The present study evaluated the relation-ship between preoperative hyperuricemia and MetS in colorectal cancer (CRC) patients and analyzed the effect of this combination on prognosis within 5 years. Patients and Methods: The study enrolled patients who had undergone radical CRC resection at three independent medical centers from January 2014 to December 2016. Patients were preoperatively categorized into four groups, those with hyperuricemia alone (H), those with MetS alone (MS), those with MetS-related hyperuricemia (MSH), and those with neither condition (control [C] group). The disease-free survival (DFS) and overall survival (OS) rates of these four groups were compared. Results: The study population consisted of 1271 patients, with 114, 201, 101, and 855 patients categorized into the H, MS, MSH and C groups, respectively. Preoperative MetS was found to be significantly associated with hyperuricemia (P < 0.001). Multivariate Cox regression analysis showed that MetS-related hyperuricemia (hazard ratio [HR] = 2.728; P < 0.001) and MetS alone (HR = 1.631; P < 0.001) were independent predictors of death, whereas simple hyperuricemia was not (P > 0.1). Relative to the C group, the MSH group had the highest rate of tumor recurrence or metastasis (HR = 5.103, P < 0.001), followed by the MS (HR = 2.231, P < 0.001) group. In contrast, prognosis did not differ significantly in the H and C groups (P > 0.1). MetS was significantly associated with poor prognosis, with MetS-related hyperuricemia resulting in a significantly poorer prognosis. In contrast, hyper-uricemia alone had no effect on the long-term prognosis of CRC patients. Conclusion: This study highlights the prognostic importance of MetS-related hyperuricemia on the survival of patients with CRC.
资助项目	Zhejiang Provincial Natural Science Foundation of ChinaNatural Science Foundation of Zhejiang Province [LY19H160025]; Medicine and Health Technology Program of Zhejiang Province [2020KY635]; Wenzhou Science & technological Project [Y20170180]
出版者	DOVE MEDICAL PRESS LTD
出版地	ALBANY
ISSN	1179-1322
卷号	13 页码:8809-8819
DOI	10.2147/CMAR.S338783
页数	11
WOS类目	Oncology
WOS研究方向	Oncology
WOS记录号	WOS:000723136100003
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	34866939
PMC记录号	PMC8633709
SCOPUSEID	2-s2.0-85119995044
通讯作者地址	[Jiang, Lei]Central Laboratory,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China ; [Jin, Rong]Department of Gastroenterology,Department of Epidemiology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China
Scopus学科分类	Oncology
引用统计	被引频次：2[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/14972
专题	附属第一医院_消化内科第一临床医学院（信息与工程学院）、附属第一医院_流行病学第一临床医学院（信息与工程学院）、附属第一医院_中心实验室
通讯作者	Jiang, Lei; Jin, Rong
作者单位	1.Department of Gastroenterology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China; 2.NAFLD Research Center,Department of Hepatology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China; 3.Department of Gastroenterology,Taizhou Hospital of Zhejiang Province,Taizhou,317000,China; 4.Central Laboratory,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China; 5.Department of Epidemiology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China
第一作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
通讯作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Feng, Qian,Tang, Liang-Jie,Luo, Ding-Hai,et al. Metabolic Syndrome-Related Hyperuricemia is Associated with a Poorer Prognosis in Patients with Colorectal Cancer: A Multicenter Retrospective Study[J]. CANCER MANAGEMENT AND RESEARCH,2021,13:8809-8819.
APA	Feng, Qian., Tang, Liang-Jie., Luo, Ding-Hai., Wang, Ying., Wu, Nan., ... & Jin, Rong. (2021). Metabolic Syndrome-Related Hyperuricemia is Associated with a Poorer Prognosis in Patients with Colorectal Cancer: A Multicenter Retrospective Study. CANCER MANAGEMENT AND RESEARCH, 13, 8809-8819.
MLA	Feng, Qian,et al."Metabolic Syndrome-Related Hyperuricemia is Associated with a Poorer Prognosis in Patients with Colorectal Cancer: A Multicenter Retrospective Study".CANCER MANAGEMENT AND RESEARCH 13(2021):8809-8819.