Co-expression networks revealed potential core lncRNAs in the triple-negative breast cancer

doi:10.1016/j.gene.2016.07.002

科研成果详情

题名	Co-expression networks revealed potential core lncRNAs in the triple-negative breast cancer
作者	Yang, Fan 1; Liu, Ye-huan1; Dong, Si-yang 1; Yao, Zhi-han 1; Lv, Lin1; Ma, Rui-min 1; Dai, Xuan-xuan1; Zhang, Xiao-hua 1; Wang, Ou-chen1; Wang, Jiao 2
发表日期	2016-10-15
发表期刊	GENE 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Triple-negative breast cancer Long non-coding RNA RMST Expression profile
其他关键词	LONG NONCODING RNAS ; TRANSCRIPTOME ANALYSIS ; IDENTIFICATION ; EXPRESSION ; SUBTYPES
摘要	Triple-negative breast cancer (TNBC) is an aggressive type of breast cancer with unfavorable outcome. It is urgent to explore novel biomarkers and potential therapeutic targets in this malignancy. Increasing knowledge of long noncoding RNAs (lncRNAs) significantly deepens our understanding of cancer biology. Here, we sequenced eight paired TNBC tumor tissues and non-cancerous tissues, and validated significantly differentially expressed IncRNAs. Gene ontology (GO) and pathway analysis were used to investigate the function of differentially expressed mRNAs. Further, potential core lncRNAs in TNBC were identified by co-expression networks. Kaplan-Meier analysis also indicated that breast cancer patients with lower expression level of rhabdomyosarcoma 2 associated transcript (RMST), one of the potential core IncRNAs, had worse overall survival. To the best of our knowledge, it was the first report that RMST was involved in breast cancer. Our research provided a rich resource to the research community for further investigating lncRNAs functions and identifying lncRNAs with diagnostic and therapeutic potentials in TNBC. (C) 2016 Elsevier B.V. All rights reserved.
资助项目	Key Project of Science and Technology Innovation Team of Zhejiang Province [2013TD10]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81372380]
出版者	ELSEVIER
出版地	AMSTERDAM
ISSN	0378-1119
EISSN	1879-0038
卷号	591 期号:2 页码:471-477
DOI	10.1016/j.gene.2016.07.002
页数	7
WOS类目	Genetics & Heredity
WOS研究方向	Genetics & Heredity
WOS记录号	WOS:000383302300022
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	27380926
SCOPUSEID	2-s2.0-84979680210
通讯作者地址	[Zhang, Xiao-hua]Department of Surgical Oncology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China
Scopus学科分类	Genetics
引用统计	被引频次：36[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/14901
专题	附属第一医院_肿瘤外科眼视光学院（生物医学工程学院）、附属眼视光医院
通讯作者	Zhang, Xiao-hua
作者单位	1.Department of Surgical Oncology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China; 2.Eye Hospital,Wenzhou Medical University,Wenzhou,China
第一作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院; 肿瘤外科
通讯作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院; 肿瘤外科
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Yang, Fan,Liu, Ye-huan,Dong, Si-yang,et al. Co-expression networks revealed potential core lncRNAs in the triple-negative breast cancer[J]. GENE,2016,591(2):471-477.
APA	Yang, Fan., Liu, Ye-huan., Dong, Si-yang., Yao, Zhi-han., Lv, Lin., ... & Wang, Jiao. (2016). Co-expression networks revealed potential core lncRNAs in the triple-negative breast cancer. GENE, 591(2), 471-477.
MLA	Yang, Fan,et al."Co-expression networks revealed potential core lncRNAs in the triple-negative breast cancer".GENE 591.2(2016):471-477.