Impact of non-alcoholic fatty liver disease and smoking on colorectal polyps

doi:10.18632/oncotarget.20462

科研成果详情

题名	Impact of non-alcoholic fatty liver disease and smoking on colorectal polyps
作者	Chen, Qin-Fen1; Zhou, Xiao-Dong2; Fang, Dan-Hong3; Sun, Yang-Jie 1; Zhao, Qian1; Huang, Jun-Hua 1; Jin, Yin1; Wu, Jian-Sheng3
发表日期	2017-09-26
发表期刊	ONCOTARGET 影响因子和分区
语种	英语
原始文献类型	Article
关键词	colorectal polyps smoking non-alcoholic fatty liver disease health check
其他关键词	METABOLIC SYNDROME ; ADENOMATOUS POLYPS ; CIGARETTE-SMOKING ; CANCER ; RISK ; ASSOCIATION ; INFLAMMATION ; COLONOSCOPY ; POPULATION ; RECURRENCE
摘要	Objectives: Non-alcoholic fatty liver disease (NAFLD) and smoking have similar mechanisms of promoting colorectal polyps. The potential link between NAFLD and smoking in men and colorectal polyps has not been adequately evaluated. The aim is to investigate this association. Methods: A retrospective cross-sectional study was conducted on 2409 individuals undergoing a health check. Univariate and multivariate logistic regression were performed for analyzing the association between risk factors and colorectal polyps. Individuals were divided into four groups: Q1: NAFLD (-)/smoking (-); Q2: NAFLD (+)/smoking (-); Q3: NAFLD (-)/smoking (+); Q4: NAFLD (+)/smoking (+). Logistic analyses were used to explore associations for the whole study population and stratified groups. Results: The prevalence of colorectal polyps was 38.8% in males, and that of colorectal polyps in smokers and individuals with NAFLD were 47.0% (428/911) and 42.9% (267/622), respectively. With Q1 as reference, subjects with NAFLD (+) and smoking habits (+) had the highest ORs for colorectal polyps (OR = 2.64, 95% CI: 1.91 - 3.64, P < 0.001), adenomatous polyps (OR = 2.06, 95% CI: 1.38 - 3.05, P < 0.05), non-adenomatous polyps (OR = 1.97, 95% CI: 1.39 - 2.80, P < 0.05), = 3 polyps (OR = 2.05, 95% CI: 1.31 - 3.22, P < 0.05) and proximal polyps (OR = 1.58, 95% CI: 1.02 - 2.45, P < 0.05) after adjusting for confounding variables. Conclusions: Men with NAFLD and smoking habits have an increasing risk of colorectal polyps.
出版者	IMPACT JOURNALS LLC
出版地	ORCHARD PARK
ISSN	1949-2553
EISSN	1949-2553
卷号	8 期号:43 页码:74927-74935
DOI	10.18632/oncotarget.20462
页数	9
WOS类目	Oncology ; Cell Biology
WOS研究方向	Oncology ; Cell Biology
WOS记录号	WOS:000411760400127
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	29088835
PMC记录号	PMC5650390
SCOPUSEID	2-s2.0-85030099878
通讯作者地址	[Wu, Jian-Sheng]Department of Gastroenterology,First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China
Scopus学科分类	Oncology
引用统计	被引频次：2[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/14890
专题	附属第一医院第一临床医学院（信息与工程学院）、附属第一医院_医疗保健中心
通讯作者	Wu, Jian-Sheng
作者单位	1.Department of Gastroenterology,First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China; 2.Department of Cardiovascular Medicine,First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China; 3.Medical and Health Care Center,First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China
第一作者单位	附属第一医院
通讯作者单位	附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Chen, Qin-Fen,Zhou, Xiao-Dong,Fang, Dan-Hong,et al. Impact of non-alcoholic fatty liver disease and smoking on colorectal polyps[J]. ONCOTARGET,2017,8(43):74927-74935.
APA	Chen, Qin-Fen., Zhou, Xiao-Dong., Fang, Dan-Hong., Sun, Yang-Jie., Zhao, Qian., ... & Wu, Jian-Sheng. (2017). Impact of non-alcoholic fatty liver disease and smoking on colorectal polyps. ONCOTARGET, 8(43), 74927-74935.
MLA	Chen, Qin-Fen,et al."Impact of non-alcoholic fatty liver disease and smoking on colorectal polyps".ONCOTARGET 8.43(2017):74927-74935.