The Overexpression and Clinical Significance of AP1S1 in Breast Cancer

doi:10.2147/CMAR.S346519

科研成果详情

题名	The Overexpression and Clinical Significance of AP1S1 in Breast Cancer
作者	Zheng, Danni1; Fu, Weida1; Jin, Lingli 1; Jiang, Xiaofang 2; Jiang, Wenjie1; Guan, Yaoyao 3; Hao, Rutian1
发表日期	2022
发表期刊	CANCER MANAGEMENT AND RESEARCH 影响因子和分区
语种	英语
原始文献类型	Article
关键词	breast cancer immune infiltration prognosis oncogene
其他关键词	DENDRITIC CELLS ; MEDNIK SYNDROME ; MECHANISMS ; ADAPTERS ; DEFECT
摘要	Purpose: To explore the mechanism of AP1S1 in breast cancer. Methods and Results: In different datasets, we found that AP1S1 is more highly expressed in breast tumors, which was furthermore verified in our local cohort.Immune infiltration analysis showed that AP1S1 was related to a variety of immune cells. The higher AP1S1 expression was negatively correlated with a variety of immune infiltrating cells, suggesting that AP1S1 may affect cellular immunity.Clinical analysis showed that patients with higher AP1S1 expression had higher estrogen receptor gene expression and were more prone to distant metastasis and lymph node metastasis.The overall survival rate, disease-specific survival rate, and progression free interval time were worse in the group with higher AP1S1 expression. AP1S1 may be a potential oncogene of breast cancer, and overexpression is related to the poor prognosis of breast cancer.Therefore, a nomogram was constructed, along with correlated gene analysis and functional analysis to further explore the carcinogenic mechanism, practical clinical issues, and value of AP1S1. Conclusion: AP1S1 is a potential oncogene of breast cancer.
资助项目	Natural Science Foundation of Zhejiang Province [LGF18H160032]
出版者	DOVE MEDICAL PRESS LTD
出版地	ALBANY
ISSN	1179-1322
卷号	14 页码:1475-1492
DOI	10.2147/CMAR.S346519
页数	18
WOS类目	Oncology
WOS研究方向	Oncology
WOS记录号	WOS:000789263800004
收录类别	SCIE ; SCOPUS ; PUBMED
URL	查看原文
PubMed ID	35463798
SCOPUSEID	2-s2.0-85129052469
通讯作者地址	[Guan, Yaoyao]Department of Plastic Surgery,Sir Run-Run Hospital Affiliated to Zhejiang University,Hangzhou,China ; [Hao, Rutian]Department of Breast Surgery,The First Affiliated Hospital of Wenzhou Medical University,Zhejiang,Wenzhou,China
Scopus学科分类	Oncology
引用统计	被引频次：1[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/148716
专题	附属第一医院第一临床医学院（信息与工程学院）、附属第一医院_内科学_神经内科
通讯作者	Guan, Yaoyao; Hao, Rutian
作者单位	1.Department of Breast Surgery,The First Affiliated Hospital of Wenzhou Medical University,Zhejiang,Wenzhou,China; 2.Department of Neurology,The First Affiliated Hospital of Wenzhou Medical University,Zhejiang,Wenzhou,China; 3.Department of Plastic Surgery,Sir Run-Run Hospital Affiliated to Zhejiang University,Hangzhou,China
第一作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
通讯作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Zheng, Danni,Fu, Weida,Jin, Lingli,et al. The Overexpression and Clinical Significance of AP1S1 in Breast Cancer[J]. CANCER MANAGEMENT AND RESEARCH,2022,14:1475-1492.
APA	Zheng, Danni., Fu, Weida., Jin, Lingli., Jiang, Xiaofang., Jiang, Wenjie., ... & Hao, Rutian. (2022). The Overexpression and Clinical Significance of AP1S1 in Breast Cancer. CANCER MANAGEMENT AND RESEARCH, 14, 1475-1492.
MLA	Zheng, Danni,et al."The Overexpression and Clinical Significance of AP1S1 in Breast Cancer".CANCER MANAGEMENT AND RESEARCH 14(2022):1475-1492.