MDL-800, the SIRT6 Activator, Suppresses Inflammation via the NF-kappa B Pathway and Promotes Angiogenesis to Accelerate Cutaneous Wound Healing in Mice

doi:10.1155/2022/1619651

科研成果详情

题名	MDL-800, the SIRT6 Activator, Suppresses Inflammation via the NF-kappa B Pathway and Promotes Angiogenesis to Accelerate Cutaneous Wound Healing in Mice
作者	Jiang, Xiaoqi 1,2; Yao, Zhe1,3; Wang, Kangyan3; Lou, Lihua1; Xue, Kaikai1,3; Chen, Jinghao3; Zhang, Guojian1,3; Zhang, Yu 3; Du, Jiqing 4,5,6; Lin, Cai1; Xiao, Jian1,2,5,6
发表日期	2022-04-27
发表期刊	OXIDATIVE MEDICINE AND CELLULAR LONGEVITY 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Mammals Tissue regeneration Angiogenesis Anti-inflammatory effects Cutaneous wounds Deacetylase Inflammatory mediators Mice models Molecular mechanism NAD + Sirtuin Wound healing
其他关键词	BIOLOGY ; REPAIR ; TISSUE
摘要	Sirtuin 6 (SIRT6) is an NAD(+)-dependent deacetylase belonging to the sirtuin family. It has been shown to participate in wound healing and some inflammation-related disorders. However, the effect of MDL-800, a highly efficient and selective SIRT6 activator, on wound healing and inflammation has not been reported. Therefore, this study investigated whether MDL-800 confers anti-inflammatory effects and promotes wound healing and uncovered the molecular mechanisms involved. This was achieved using mouse models of full-thickness wounds. Results showed that MDL-800 significantly downregulated inflammation by attenuating the release of inflammatory mediators and improved collagen deposition and neovascularization of wounds, thereby accelerating cutaneous wound healing. Furthermore, MDL-800 significantly downregulated expression levels of TNF-alpha and IL-6 in the dorsal skin tissue of mice via the NF-kappa B pathway. These results demonstrated that MDL-800 exerted anti-inflammatory and prohealing effects, indicating that the SIRT6/NF-kappa B/I kappa B signaling pathway may play an important role in wound healing.
资助项目	Key Scientific and Technological Innovation Projects of Wenzhou [ZY20200023]; Wenzhou Innovation Team (Growth Factor Drug Development) [201801]; CAMS Innovation Fund for Medical Sciences [2019-I2M-5-028]; Zhejiang Provincial Basic Public Welfare Research Program [2017C01054]; Medical Health Science and Technology Project of Zhejiang Province [2019KY464]; Wenzhou Municipal Science and Technology Bureau [ZY2019003, Y2019-0123]
出版者	HINDAWI LTD
出版地	LONDON
ISSN	1942-0900
EISSN	1942-0994
卷号	2022 页码:1619651
DOI	10.1155/2022/1619651
页数	14
WOS类目	Cell Biology
WOS研究方向	Cell Biology
WOS记录号	WOS:000793739300002
收录类别	SCIE ; EI ; SCOPUS ; PUBMED
EI入藏号	20222012114781
EI主题词	Pathology
EI分类号	461.1 Biomedical Engineering ; 461.6 Medicine and Pharmacology
URL	查看原文
PubMed ID	35528512
SCOPUSEID	2-s2.0-85129781047
通讯作者地址	[Lin, Cai]Department of Burn,Wound Repair and Regenerative Medicine Center,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China ; [Xiao, Jian]Department of Burn,Wound Repair and Regenerative Medicine Center,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China ; [Du, Jiqing]Department of Orthopaedics,The Affiliated Pingyang Hospital,Wenzhou Medical University,Wenzhou,325499,China
Scopus学科分类	Biochemistry;Aging;Cell Biology
引用统计	被引频次[WOS]：0 [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/148684
专题	药学院（分析测试中心）附属第二医院附属第一医院第二临床医学院、附属第二医院、育英儿童医院研究生工作部（研究生院）其他_附属平阳医院（平阳县人民医院）
通讯作者	Du, Jiqing; Lin, Cai; Xiao, Jian
作者单位	1.Department of Burn,Wound Repair and Regenerative Medicine Center,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China; 2.School of Pharmaceutical Sciences,Wenzhou Medical University,Wenzhou,325035,China; 3.Department of Orthopaedics,The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University,Wenzhou,325027,China; 4.Department of Orthopaedics,The Affiliated Pingyang Hospital,Wenzhou Medical University,Wenzhou,325499,China; 5.Oujiang Laboratory,Zhejiang Lab for Regenerative Medicine,Vision and Brain Health,Wenzhou,325001,China; 6.Research Units of Clinical Translation of Cell Growth Factors and Diseases Research,Chinese Academy of Medical Sciences,Wenzhou,325027,China
第一作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院; 药学院（分析测试中心）
通讯作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院; 附属平阳医院（平阳县人民医院）
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Jiang, Xiaoqi,Yao, Zhe,Wang, Kangyan,et al. MDL-800, the SIRT6 Activator, Suppresses Inflammation via the NF-kappa B Pathway and Promotes Angiogenesis to Accelerate Cutaneous Wound Healing in Mice[J]. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY,2022,2022:1619651.
APA	Jiang, Xiaoqi., Yao, Zhe., Wang, Kangyan., Lou, Lihua., Xue, Kaikai., ... & Xiao, Jian. (2022). MDL-800, the SIRT6 Activator, Suppresses Inflammation via the NF-kappa B Pathway and Promotes Angiogenesis to Accelerate Cutaneous Wound Healing in Mice. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2022, 1619651.
MLA	Jiang, Xiaoqi,et al."MDL-800, the SIRT6 Activator, Suppresses Inflammation via the NF-kappa B Pathway and Promotes Angiogenesis to Accelerate Cutaneous Wound Healing in Mice".OXIDATIVE MEDICINE AND CELLULAR LONGEVITY 2022(2022):1619651.