Roles of the fibroblast growth factor signal transduction system in tissue injury repair

doi:10.1093/burnst/tkac005

科研成果详情

题名	Roles of the fibroblast growth factor signal transduction system in tissue injury repair
作者	Chen, Keyang1,3,4; Rao, Zhiheng1,3,4; Dong, Siyang1,2; Chen, Yajing1; Wang, Xulan1; Luo, Yongde 1,2,4; Gong, Fanghua1,4; Li, Xiaokun1,4
发表日期	2022
发表期刊	BURNS & TRAUMA 影响因子和分区
语种	英语
原始文献类型	Review
关键词	Tissue injury Repair Regeneration Cell growth Fibroblast growth factor Signal transduction
其他关键词	PLACEBO-CONTROLLED TRIAL ; SPINAL-CORD-INJURY ; TYMPANIC MEMBRANE PERFORATIONS ; SKELETAL-MUSCLE REGENERATION ; STEM-CELLS ; FACTOR-I ; INTRAARTICULAR SPRIFERMIN ; MYOCARDIAL-INFARCTION ; FACTOR RECEPTOR-3 ; PI3K-AKT-RAC1 PATHWAY
摘要	Following injury, tissue autonomously initiates a complex repair process, resulting in either partial recovery or regeneration of tissue architecture and function in most organisms. Both the repair and regeneration processes are highly coordinated by a hierarchy of interplay among signal transduction pathways initiated by different growth factors, cytokines and other signaling molecules under normal conditions. However, under chronic traumatic or pathological conditions, the reparative or regenerative process of most tissues in different organs can lose control to different extents, leading to random, incomplete or even flawed cell and tissue reconstitution and thus often partial restoration of the original structure and function, accompanied by the development of fibrosis, scarring or even pathogenesis that could cause organ failure and death of the organism. Ample evidence suggests that the various combinatorial fibroblast growth factor (FGF) and receptor signal transduction systems play prominent roles in injury repair and the remodeling of adult tissues in addition to embryonic development and regulation of metabolic homeostasis. In this review, we attempt to provide a brief update on our current understanding of the roles, the underlying mechanisms and clinical application of FGFs in tissue injury repair.
资助项目	Wenzhou Medical University; First Affiliated Hospital; Chinese Academy of Medical Sciences (CAMS) Innovation Fund for Medical Sciences [2019-I2M-5-028]
出版者	OXFORD UNIV PRESS
出版地	OXFORD
ISSN	2321-3868
EISSN	2321-3876
卷号	10 页码:tkac005
DOI	10.1093/burnst/tkac005
页数	21
WOS类目	Emergency Medicine ; Dermatology ; Surgery
WOS研究方向	Emergency Medicine ; Dermatology ; Surgery
WOS记录号	WOS:000808362700005
收录类别	SCIE ; SCOPUS ; PUBMED
URL	查看原文
PubMed ID	35350443
SCOPUSEID	2-s2.0-85127801286
通讯作者地址	[Li, Xiaokun]School of Pharmaceutical Sciences,Wenzhou Medical University,Zhejiang,Wenzhou,325000,China ; [Gong, Fanghua]School of Pharmaceutical Sciences,Wenzhou Medical University,Zhejiang,Wenzhou,325000,China ; [Luo, Yongde]School of Pharmaceutical Sciences,Wenzhou Medical University,Zhejiang,Wenzhou,325000,China
Scopus学科分类	Surgery;Immunology and Allergy;Emergency Medicine;Biomedical Engineering;Dermatology;Critical Care and Intensive Care Medicine
引用统计	被引频次[WOS]：0 [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/148611
专题	药学院（分析测试中心）附属第二医院附属第一医院第二临床医学院、附属第二医院、育英儿童医院卓越中心_国际生长因子研究院
通讯作者	Luo, Yongde; Gong, Fanghua; Li, Xiaokun
作者单位	1.School of Pharmaceutical Sciences,Wenzhou Medical University,Zhejiang,Wenzhou,325000,China; 2.Department of Breast Surgery,The First Affiliated Hospital of Wenzhou Medical University,Zhejiang,Wenzhou,325000,China; 3.Department of Neurology,The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University,Zhejiang,Wenzhou,325000,China; 4.Research Units of Clinical Translation of Cell Growth Factors and Diseases Research,Chinese Academy of Medical Science,Wenzhou Medical University,Zhejiang,Wenzhou,325000,China
第一作者单位	药学院（分析测试中心）; 第二临床医学院，附属第二医院、育英儿童医院; 附属第二医院; 温州医科大学
通讯作者单位	药学院（分析测试中心）
第一作者的第一单位	药学院（分析测试中心）
推荐引用方式 GB/T 7714	Chen, Keyang,Rao, Zhiheng,Dong, Siyang,et al. Roles of the fibroblast growth factor signal transduction system in tissue injury repair[J]. BURNS & TRAUMA,2022,10:tkac005.
APA	Chen, Keyang., Rao, Zhiheng., Dong, Siyang., Chen, Yajing., Wang, Xulan., ... & Li, Xiaokun. (2022). Roles of the fibroblast growth factor signal transduction system in tissue injury repair. BURNS & TRAUMA, 10, tkac005.
MLA	Chen, Keyang,et al."Roles of the fibroblast growth factor signal transduction system in tissue injury repair".BURNS & TRAUMA 10(2022):tkac005.