题名 | Roles of the fibroblast growth factor signal transduction system in tissue injury repair |
作者 | |
发表日期 | 2022 |
发表期刊 | BURNS & TRAUMA 影响因子和分区 |
语种 | 英语 |
原始文献类型 | Review |
关键词 | Tissue injury Repair Regeneration Cell growth Fibroblast growth factor Signal transduction |
其他关键词 | PLACEBO-CONTROLLED TRIAL ; SPINAL-CORD-INJURY ; TYMPANIC MEMBRANE PERFORATIONS ; SKELETAL-MUSCLE REGENERATION ; STEM-CELLS ; FACTOR-I ; INTRAARTICULAR SPRIFERMIN ; MYOCARDIAL-INFARCTION ; FACTOR RECEPTOR-3 ; PI3K-AKT-RAC1 PATHWAY |
摘要 | Following injury, tissue autonomously initiates a complex repair process, resulting in either partial recovery or regeneration of tissue architecture and function in most organisms. Both the repair and regeneration processes are highly coordinated by a hierarchy of interplay among signal transduction pathways initiated by different growth factors, cytokines and other signaling molecules under normal conditions. However, under chronic traumatic or pathological conditions, the reparative or regenerative process of most tissues in different organs can lose control to different extents, leading to random, incomplete or even flawed cell and tissue reconstitution and thus often partial restoration of the original structure and function, accompanied by the development of fibrosis, scarring or even pathogenesis that could cause organ failure and death of the organism. Ample evidence suggests that the various combinatorial fibroblast growth factor (FGF) and receptor signal transduction systems play prominent roles in injury repair and the remodeling of adult tissues in addition to embryonic development and regulation of metabolic homeostasis. In this review, we attempt to provide a brief update on our current understanding of the roles, the underlying mechanisms and clinical application of FGFs in tissue injury repair. |
资助项目 | Wenzhou Medical University; First Affiliated Hospital; Chinese Academy of Medical Sciences (CAMS) Innovation Fund for Medical Sciences [2019-I2M-5-028] |
出版者 | OXFORD UNIV PRESS |
出版地 | OXFORD |
ISSN | 2321-3868 |
EISSN | 2321-3876 |
卷号 | 10页码:tkac005 |
DOI | 10.1093/burnst/tkac005 |
页数 | 21 |
WOS类目 | Emergency Medicine ; Dermatology ; Surgery |
WOS研究方向 | Emergency Medicine ; Dermatology ; Surgery |
WOS记录号 | WOS:000808362700005 |
收录类别 | SCIE ; SCOPUS ; PUBMED |
URL | 查看原文 |
PubMed ID | 35350443 |
SCOPUSEID | 2-s2.0-85127801286 |
通讯作者地址 | [Li, Xiaokun]School of Pharmaceutical Sciences,Wenzhou Medical University,Zhejiang,Wenzhou,325000,China ; [Gong, Fanghua]School of Pharmaceutical Sciences,Wenzhou Medical University,Zhejiang,Wenzhou,325000,China ; [Luo, Yongde]School of Pharmaceutical Sciences,Wenzhou Medical University,Zhejiang,Wenzhou,325000,China |
Scopus学科分类 | Surgery;Immunology and Allergy;Emergency Medicine;Biomedical Engineering;Dermatology;Critical Care and Intensive Care Medicine |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | https://kms.wmu.edu.cn/handle/3ETUA0LF/148611 |
专题 | 药学院(分析测试中心) 附属第二医院 附属第一医院 第二临床医学院、附属第二医院、育英儿童医院 卓越中心_国际生长因子研究院 |
通讯作者 | Luo, Yongde; Gong, Fanghua; Li, Xiaokun |
作者单位 | 1.School of Pharmaceutical Sciences,Wenzhou Medical University,Zhejiang,Wenzhou,325000,China; 2.Department of Breast Surgery,The First Affiliated Hospital of Wenzhou Medical University,Zhejiang,Wenzhou,325000,China; 3.Department of Neurology,The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University,Zhejiang,Wenzhou,325000,China; 4.Research Units of Clinical Translation of Cell Growth Factors and Diseases Research,Chinese Academy of Medical Science,Wenzhou Medical University,Zhejiang,Wenzhou,325000,China |
第一作者单位 | 药学院(分析测试中心); 第二临床医学院,附属第二医院、育英儿童医院; 附属第二医院; 温州医科大学 |
通讯作者单位 | 药学院(分析测试中心) |
第一作者的第一单位 | 药学院(分析测试中心) |
推荐引用方式 GB/T 7714 | Chen, Keyang,Rao, Zhiheng,Dong, Siyang,et al. Roles of the fibroblast growth factor signal transduction system in tissue injury repair[J]. BURNS & TRAUMA,2022,10:tkac005. |
APA | Chen, Keyang., Rao, Zhiheng., Dong, Siyang., Chen, Yajing., Wang, Xulan., ... & Li, Xiaokun. (2022). Roles of the fibroblast growth factor signal transduction system in tissue injury repair. BURNS & TRAUMA, 10, tkac005. |
MLA | Chen, Keyang,et al."Roles of the fibroblast growth factor signal transduction system in tissue injury repair".BURNS & TRAUMA 10(2022):tkac005. |
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