Nomogram based on intramuscular adipose tissue content for predicting the prognosis of patients with gallbladder cancer after radical resection

doi:10.21037/tcr-22-123

科研成果详情

题名	Nomogram based on intramuscular adipose tissue content for predicting the prognosis of patients with gallbladder cancer after radical resection
作者	Zheng, Chongming1; Chen, Xiaotian 2; Zhang, Zhewei 2; Li, Anlvna 2; Wang, Junwei2; Cai, Tingting2; Tang, Yanping 2; An, Xuewen 2; Lu, Fei2; Chen, Gang1; Xiang, Youqun3
发表日期	2022-07
发表期刊	TRANSLATIONAL CANCER RESEARCH 影响因子和分区
语种	英语
原始文献类型	Article ; Early Access
关键词	Intramuscular adipose tissue content (IMAC) gallbladder cancer (GBC) prognosis sarcopenia nomogram
其他关键词	SKELETAL-MUSCLE ; ALBUMIN RATIO ; OBESITY ; HEPATECTOMY ; FIBRINOGEN ; SARCOPENIA ; OUTCOMES
摘要	Background: To investigate the predictive value of intramuscular adipose tissue content (IMAC) on the outcome of gallbladder cancer (GBC) patients after resection, by then develop and evaluate a nomogram to predict the prognosis of GBC patients. Methods: This research incorporated 123 patients with a pathological diagnosis of GBC. Evaluating the prognosis by the Kaplan-Meier method. Independent predictors of overall survival (OS) were screened using multifactorial Cox regression analysis, and a nomogram was constructed from these. Consistency index and calibration curve were used to identify and calibrate the nomogram. The accuracy of the nomogram was assessed by receiver operating characteristic (ROC) curve and decision curve analysis (DCA) was used to assess the net benefit. Results: Patients with high IMAC showed a worse prognosis. A nomogram was constructed to predict OS based on IMAC. The C-index for the nomogram was 0.804. The calibration curve showed well performance of the nomogram. The area under the ROC curve (AUC) for the nomogram at three and five years was 0.839 and 0.785, respectively. A high net benefit was demonstrated by DCA. Conclusions: IMAC was a valid predictor for GBC patients. A nomogram with good performance is constructed to predict the prognosis of GBC patients.
资助项目	National Natural Science Foundation of China [82072685]
出版者	AME PUBL CO
出版地	SHATIN
ISSN	2218-676X
EISSN	2219-6803
卷号	11 期号:7 页码:1898-1908
DOI	10.21037/tcr-22-123
页数	11
WOS类目	Oncology
WOS研究方向	Oncology
WOS记录号	WOS:000806745000001
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	35966285
SCOPUSEID	2-s2.0-85135216993
通讯作者地址	[Chen, Gang]Department of Hepatobiliary Surgery,The First Affiliated Hospital of Wenzhou Medical University,Fuxue Road, Wenzhou,Zhejiang,325035,China ; [Xiang, Youqun]Department of Colorectal Surgery,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China
Scopus学科分类	Oncology;Radiology, Nuclear Medicine and Imaging;Cancer Research
引用统计	被引频次[WOS]：0 [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/148399
专题	附属第一医院_肝胆外科附属第一医院_肛肠外科
通讯作者	Chen, Gang; Xiang, Youqun
作者单位	1.Department of Hepatobiliary Surgery,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China; 2.Wenzhou Medical University,Wenzhou,China; 3.Department of Colorectal Surgery,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China
第一作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
通讯作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Zheng, Chongming,Chen, Xiaotian,Zhang, Zhewei,et al. Nomogram based on intramuscular adipose tissue content for predicting the prognosis of patients with gallbladder cancer after radical resection[J]. TRANSLATIONAL CANCER RESEARCH,2022,11(7):1898-1908.
APA	Zheng, Chongming., Chen, Xiaotian., Zhang, Zhewei., Li, Anlvna., Wang, Junwei., ... & Xiang, Youqun. (2022). Nomogram based on intramuscular adipose tissue content for predicting the prognosis of patients with gallbladder cancer after radical resection. TRANSLATIONAL CANCER RESEARCH, 11(7), 1898-1908.
MLA	Zheng, Chongming,et al."Nomogram based on intramuscular adipose tissue content for predicting the prognosis of patients with gallbladder cancer after radical resection".TRANSLATIONAL CANCER RESEARCH 11.7(2022):1898-1908.