Investigate the effect of COVID-19 inactivated vaccine on sperm parameters and embryo quality in in vitro fertilization

doi:10.1111/and.14483

科研成果详情

题名	Investigate the effect of COVID-19 inactivated vaccine on sperm parameters and embryo quality in in vitro fertilization
作者	Xia, Weiting1; Zhao, Junzhao2; Hu, Yangyang 2; Fang, Lizi2; Wu, Shenghao2
发表日期	2022-07
发表期刊	ANDROLOGIA 影响因子和分区
语种	英语
原始文献类型	Article
关键词	COVID-19 in vitro fertilization inactivated vaccine male fertility sperm parameters
其他关键词	MALE-FERTILITY ; SARS-COV-2 ; SEMEN ; INFERTILITY
摘要	Since the reproductive toxicity of COVID-19 vaccines have not been assessed in previous clinical trials, and studies have shown that SARS-CoV-2 is associated with a decrease in sperm parameters. Although it has been reported that the mRNA SARS-CoV-2 vaccines do not adversely affect semen parameters, whether this conclusion applies to inactivated vaccines remains unclear. Here, we conducted a study among patients who accepted in vitro fertilization (IVF) at the reproductive centre between June and August of 2021. In the enrolled cases, men who have completed two doses of COVID-19 inactivated vaccine were included in vaccine group (N = 105), and those who were not vaccinated were included in control group (N = 155). In this study, we compare the sperm parameters and embryo quality between these two groups. Our data showed that the sperm parameters were similar in terms of volume, sperm concentration, sperm count, progressive motility, total motility and total motile sperm count between these two groups. Similarly, no significant differences were observed in IVF outcomes. The mean number of 2PN, cleavage-stage embryos, blastocysts, and good-quality blastocysts was 8.59 +/- 4.47, 5.06 +/- 3.17 and 2.08 +/- 1.79 in vaccine group, 7.75 +/- 4.14, 4.34 +/- 3.06 and 1.74 +/- 1.54 in control group, respectively. The high-quality blastocyst rate was 41.05% (218 of 531) in vaccine group and 40.03% (269 of 672) in control group (p > 0.05). In addition, no differences were observed in biochemical and clinical pregnancy rates between the two groups. In summary, our results revealed that COVID-19 inactivated vaccine administration exhibited no negative effect on sperm parameters and embryo quality in IVF.
出版者	WILEY
出版地	HOBOKEN
ISSN	0303-4569
EISSN	1439-0272
卷号	54 期号:6 页码:e14483
DOI	10.1111/and.14483
页数	7
WOS类目	Andrology
WOS研究方向	Endocrinology & Metabolism
WOS记录号	WOS:000799666100001
收录类别	SCIE ; SCOPUS ; PUBMED
URL	查看原文
PubMed ID	35610731
SCOPUSEID	2-s2.0-85130505697
通讯作者地址	[Wu, Shenghao]Reproductive Medicine Center,Department of Obstetrics and Gynecology,The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University,Zhejiang,Wenzhou,China
Scopus学科分类	Endocrinology;Urology
引用统计	被引频次：2[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/148386
专题	第一临床医学院（信息与工程学院）、附属第一医院_妇产科学_妇科附属第二医院附属第一医院第二临床医学院、附属第二医院、育英儿童医院
通讯作者	Wu, Shenghao
作者单位	1.Department of Gynecology,The First Affiliated Hospital of Wenzhou Medical University,Zhejiang,Wenzhou,China; 2.Reproductive Medicine Center,Department of Obstetrics and Gynecology,The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University,Zhejiang,Wenzhou,China
第一作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
通讯作者单位	第二临床医学院，附属第二医院、育英儿童医院; 附属第二医院; 妇产科
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Xia, Weiting,Zhao, Junzhao,Hu, Yangyang,et al. Investigate the effect of COVID-19 inactivated vaccine on sperm parameters and embryo quality in in vitro fertilization[J]. ANDROLOGIA,2022,54(6):e14483.
APA	Xia, Weiting, Zhao, Junzhao, Hu, Yangyang, Fang, Lizi, & Wu, Shenghao. (2022). Investigate the effect of COVID-19 inactivated vaccine on sperm parameters and embryo quality in in vitro fertilization. ANDROLOGIA, 54(6), e14483.
MLA	Xia, Weiting,et al."Investigate the effect of COVID-19 inactivated vaccine on sperm parameters and embryo quality in in vitro fertilization".ANDROLOGIA 54.6(2022):e14483.