Inflammation-Related Gene Signature for Predicting the Prognosis of Head and Neck Squamous Cell Carcinoma

doi:10.2147/IJGM.S354349

科研成果详情

题名	Inflammation-Related Gene Signature for Predicting the Prognosis of Head and Neck Squamous Cell Carcinoma
作者	Lu, Yilong 1; Jia, Zengrong 2
发表日期	2022
发表期刊	INTERNATIONAL JOURNAL OF GENERAL MEDICINE 影响因子和分区
语种	英语
原始文献类型	Article
关键词	TCGA inflammation-related gene prognosis HNSCC
其他关键词	GROWTH-FACTOR RECEPTOR ; KAPPA-B ; CANCER ; EXPRESSION ; EPIDEMIOLOGY ; ACTIVATION ; INTERPLAY
摘要	Purpose: The inflammatory response was associated with the prognosis of head and neck squamous cell carcinoma (HNSCC). This study aimed to perform a novel prognostic signature based on inflammation-related genes (IRGs) for a better understanding of the prognosis of HNSCC. Patients and Methods: IRGs were obtained from The Cancer Genome Atlas (TCGA) database and the Gene Expression Omnibus (GEO) database. Functional enrichment analysis was performed to explore potential pathways. Univariate and multivariate Cox regression as well as the Least Absolute Shrinkage and Selection Operator (LASSO) were utilized to construct an IRGs-based prognostic model on TCGA database and the GEO database was utilized for outcome validation. The nomogram model was constructed based on independent prognostic factors after univariate and multivariate Cox regression. The immune cell infiltration level was analyzed via the Tumor Immune Estimation Resource (TIMER) database. Results: In this study, we confirmed that 60% IRGs were abnormally expressed in HNSCC samples, and these were associated with important oncobiology. Then, a prognostic signature comprising 7 hub genes was generated based on TCGA database. The results were validated in 97 patients from GSE41613. A nomogram comprising risk score, age, M stage and N stage was generated to improve the accuracy of prognosis evaluation. The immune cell infiltration analysis suggested that 5 hub genes (ADGRE1, OLR1, TIMP1, GPR132 and CCR7) were negatively correlated with tumor purity and positively correlated with the infiltration of immune cells. Conclusion: Our study established a novel signature consisting of 7 hub genes for the prognostic prediction in patients with HNSCC.
出版者	DOVE MEDICAL PRESS LTD
出版地	ALBANY
ISSN	1178-7074
EISSN	1178-7074
卷号	15 页码:4793-4805
DOI	10.2147/IJGM.S354349
页数	13
WOS类目	Medicine, General & Internal
WOS研究方向	General & Internal Medicine
WOS记录号	WOS:000798519900002
收录类别	SCIE ; SCOPUS ; PUBMED
URL	查看原文
PubMed ID	35592543
SCOPUSEID	2-s2.0-85130277269
通讯作者地址	[Jia, Zengrong]Thyroid Surgery,The First Affiliated Hospital of Wenzhou Medical University,Zhejiang,Wenzhou,325015,China
Scopus学科分类	Medicine (all)
引用统计	被引频次：1[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/148375
专题	第一临床医学院（信息与工程学院）、附属第一医院_外科学_甲状腺外科附属第一医院口腔医学院、附属口腔医院
通讯作者	Jia, Zengrong
作者单位	1.School of Stomatology,Wenzhou Medical University,Zhejiang,Wenzhou,China; 2.Thyroid Surgery,The First Affiliated Hospital of Wenzhou Medical University,Zhejiang,Wenzhou,China
第一作者单位	口腔医学院、附属口腔医院
通讯作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
第一作者的第一单位	口腔医学院、附属口腔医院
推荐引用方式 GB/T 7714	Lu, Yilong,Jia, Zengrong. Inflammation-Related Gene Signature for Predicting the Prognosis of Head and Neck Squamous Cell Carcinoma[J]. INTERNATIONAL JOURNAL OF GENERAL MEDICINE,2022,15:4793-4805.
APA	Lu, Yilong, & Jia, Zengrong. (2022). Inflammation-Related Gene Signature for Predicting the Prognosis of Head and Neck Squamous Cell Carcinoma. INTERNATIONAL JOURNAL OF GENERAL MEDICINE, 15, 4793-4805.
MLA	Lu, Yilong,et al."Inflammation-Related Gene Signature for Predicting the Prognosis of Head and Neck Squamous Cell Carcinoma".INTERNATIONAL JOURNAL OF GENERAL MEDICINE 15(2022):4793-4805.