Synergistic antitumor effect of Andrographolide and cisplatin through ROS-mediated ER stress and STAT3 inhibition in colon cancer

doi:10.1007/s12032-022-01691-2

科研成果详情

题名	Synergistic antitumor effect of Andrographolide and cisplatin through ROS-mediated ER stress and STAT3 inhibition in colon cancer
作者	Hong, Huang2; Cao, Weilan1; Wang, Quanpeng 1; Liu, Changbao 1; Huang, Chongjie1
发表日期	2022-05
发表期刊	MEDICAL ONCOLOGY 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Andrographolide Cisplatin ROS Endoplasmic reticulum stress STAT3
其他关键词	CELL-DEATH ; APOPTOSIS ; SUPPRESSION ; PANICULATA ; RESISTANCE ; PATHWAYS ; EFFICACY ; THERAPY ; LACTONE ; DAMAGE
摘要	Colon cancer is one of the most leading death-causing cancers in the world. Cisplatin has been widely used as the first-line treatment of cancer. However, its clinical application is limited by the side effects or acquired drug resistance. Hence, it is of vital clinical significance to develop novel agents that synergize with cisplatin and decrease its side effects. The aim of this study was to investigate whether Andrographolide (AP) synergistically potentiates the anti-tumor effect of cisplatin on colon cancer cells. Here, we found that AP synergizes with cisplatin in exerting anticancer activity in colon cancer cells. Further studies showed that AP potentiates cisplatin-induced endoplasmic reticulum stress and STAT3 inhibition through increasing intracellular ROS. Notably, pre-treatment of NAC, a ROS scavenger, reversed apoptosis induced by combined treatment of AP and cisplatin, while relieving the activation of endoplasmic reticulum stress as well as STAT3 inhibition. These findings indicated that ROS plays a pivotal role in mediating synergistic anticancer effects of AP and cisplatin on colon cancer cells. Overall, this study presents a potential new therapeutic strategy for the treatment of colon cancer.
资助项目	Wenzhou science and technology project [17331209]; [Y20190578]
出版者	HUMANA PRESS INC
出版地	TOTOWA
ISSN	1357-0560
EISSN	1559-131X
卷号	39 期号:5 页码:101
DOI	10.1007/s12032-022-01691-2
页数	11
WOS类目	Oncology
WOS研究方向	Oncology
WOS记录号	WOS:000798611700007
收录类别	SCIE ; SCOPUS ; PUBMED
URL	查看原文
PubMed ID	35599281
SCOPUSEID	2-s2.0-85130757561
通讯作者地址	[Liu, Changbao]Department of Anorectal Surgery,The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University,Zhejiang,Wenzhou,China ; [Huang, Chongjie]Department of Anorectal Surgery,The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University,Zhejiang,Wenzhou,China
Scopus学科分类	Hematology;Oncology;Cancer Research
引用统计	被引频次[WOS]：0 [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/148373
专题	第二临床医学院，附属第二医院、育英儿童医院
通讯作者	Liu, Changbao; Huang, Chongjie
作者单位	1.Department of Anorectal Surgery,The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University,Zhejiang,Wenzhou,China; 2.Department of General Surgery,The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University,Zhejiang,Wenzhou,China
第一作者单位	第二临床医学院，附属第二医院、育英儿童医院
通讯作者单位	第二临床医学院，附属第二医院、育英儿童医院
第一作者的第一单位	第二临床医学院，附属第二医院、育英儿童医院
推荐引用方式 GB/T 7714	Hong, Huang,Cao, Weilan,Wang, Quanpeng,et al. Synergistic antitumor effect of Andrographolide and cisplatin through ROS-mediated ER stress and STAT3 inhibition in colon cancer[J]. MEDICAL ONCOLOGY,2022,39(5):101.
APA	Hong, Huang, Cao, Weilan, Wang, Quanpeng, Liu, Changbao, & Huang, Chongjie. (2022). Synergistic antitumor effect of Andrographolide and cisplatin through ROS-mediated ER stress and STAT3 inhibition in colon cancer. MEDICAL ONCOLOGY, 39(5), 101.
MLA	Hong, Huang,et al."Synergistic antitumor effect of Andrographolide and cisplatin through ROS-mediated ER stress and STAT3 inhibition in colon cancer".MEDICAL ONCOLOGY 39.5(2022):101.