Elevated Serum Uric Acid Increases the Risk of Ischemic Stroke Recurrence and Its Inflammatory Mechanism in Older Adults

doi:10.3389/fnagi.2022.822350

科研成果详情

题名	Elevated Serum Uric Acid Increases the Risk of Ischemic Stroke Recurrence and Its Inflammatory Mechanism in Older Adults
作者	Zhu, Han-Yu1,2; Zhao, Shu-Zhen3; Zhang, Meng-Li1,2; Wang, Yan 1,2; Pan, Zhi-Ming1,2; Cheng, Hao-Ran 1; Zhao, Ke 4; Wang, Zhen1
发表日期	2022-03-08
发表期刊	FRONTIERS IN AGING NEUROSCIENCE 影响因子和分区
语种	英语
原始文献类型	Article
关键词	UA ischemic stroke recurrence NLR restricted cubic spline regression mediation analysis interaction and joint analysis
其他关键词	NEUTROPHIL/LYMPHOCYTE RATIO ; OXIDATIVE STRESS ; LYMPHOCYTE RATIO ; ALL-CAUSE ; DISEASE ; PREDICTOR ; PROGRESSION ; NEUTROPHIL ; INFARCTION ; MORTALITY
摘要	BackgroundSerum uric acid (UA) has been reported to be associated with ischemic stroke and inflammation. However, whether or not UA is related to the recurrence of ischemic stroke, and whether inflammation plays a role in the relationship between them remain inconclusive. ObjectiveWe sought to explore the relationship between UA and the recurrence of ischemic stroke and to define the role of neutrophil-to-lymphocyte ratio (NLR) in the aforementioned relationship. MethodsA total of 8,995 patients were included in this study. Basic information and blood samples were collected, and whether or not each participant experienced ischemic stroke recurrence within 3 years was documented. Patients were stratified into three groups according to their UA level, as follows: <= 266, 267-339, and >= 340 mu mol/L. COX regression and restricted cubic spline regression models were used to evaluate the clinical correlation between UA and ischemic stroke recurrence, mediation analysis and interaction and joint analysis were used to evaluate the role of NLR in the association of UA and ischemic stroke recurrence, and sensitivity and subgroup analyses were performed to test the robustness of the data. ResultsIschemic stroke recurrence was related to male sex, older age, higher UA level, higher NLR, hypertension, diabetes, and cardiovascular disease. Following adjustment for potential confounders, a high level of UA (>= 340 mu mol/L) increased the risk of recurrence by 92.6% in patients with previous ischemic stroke. We also found that NLR affects the association between UA and the recurrence of ischemic stroke in older adults, suggesting that patients with high NLR and high UA levels are at greater risk for ischemic stroke recurrence. ConclusionUA level is non-linearly associated with recurrence, and NLR has an additive interaction between UA and ischemic stroke recurrence.
资助项目	Medical Health Science and Technology Project of Zhejiang Province[2021KY377];
出版者	FRONTIERS MEDIA SA
出版地	LAUSANNE
ISSN	1663-4365
卷号	14 页码:822350
DOI	10.3389/fnagi.2022.822350
页数	9
WOS类目	Geriatrics & Gerontology ; Neurosciences
WOS研究方向	Geriatrics & Gerontology ; Neurosciences & Neurology
WOS记录号	WOS:000775126400001
收录类别	SCIE ; SCOPUS ; PUBMED
URL	查看原文
PubMed ID	35350634
SCOPUSEID	2-s2.0-85127338152
通讯作者地址	[Cheng, Hao-Ran]Department of Neurology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China ; [Wang, Zhen]Department of Neurology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China ; [Zhao, Ke]Department of Neurology,Zhuji Affiliated Hospital of Wenzhou Medical University,Zhuji,China
Scopus学科分类	Aging;Cognitive Neuroscience
引用统计	被引频次：2[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/148319
专题	第一临床医学院（信息与工程学院）、附属第一医院_内科学_神经内科第一临床医学院（信息与工程学院）、附属第一医院附属第一医院公共卫生学院_预防医学系其他_附属诸暨医院（诸暨市人民医院）
通讯作者	Cheng, Hao-Ran; Zhao, Ke; Wang, Zhen
作者单位	1.Department of Neurology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China; 2.The First Clinical College,Wenzhou Medical University,Wenzhou,China; 3.Department of Preventive Medicine,School of Public Health and Management,Wenzhou Medical University,Wenzhou,China; 4.Department of Neurology,Zhuji Affiliated Hospital of Wenzhou Medical University,Zhuji,China
第一作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
通讯作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院; 温州医科大学
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Zhu, Han-Yu,Zhao, Shu-Zhen,Zhang, Meng-Li,et al. Elevated Serum Uric Acid Increases the Risk of Ischemic Stroke Recurrence and Its Inflammatory Mechanism in Older Adults[J]. FRONTIERS IN AGING NEUROSCIENCE,2022,14:822350.
APA	Zhu, Han-Yu., Zhao, Shu-Zhen., Zhang, Meng-Li., Wang, Yan., Pan, Zhi-Ming., ... & Wang, Zhen. (2022). Elevated Serum Uric Acid Increases the Risk of Ischemic Stroke Recurrence and Its Inflammatory Mechanism in Older Adults. FRONTIERS IN AGING NEUROSCIENCE, 14, 822350.
MLA	Zhu, Han-Yu,et al."Elevated Serum Uric Acid Increases the Risk of Ischemic Stroke Recurrence and Its Inflammatory Mechanism in Older Adults".FRONTIERS IN AGING NEUROSCIENCE 14(2022):822350.