Mendelian randomization analyses for PCOS : evidence, opportunities, and challenges

doi:10.1016/j.tig.2022.01.005

科研成果详情

题名	Mendelian randomization analyses for PCOS : evidence, opportunities, and challenges
作者	Wang, Congying 1; Wu, Wei 2; Yang, Haiyan1; Ye, Zhenhong 3,4,5,6; Zhao, Yue 3,4,5,6; Liu, Jun 7; Mu, Liangshan 2
发表日期	2022-05
发表期刊	TRENDS IN GENETICS 影响因子和分区
语种	英语
原始文献类型	Review
关键词	Mendelian randomization genetic variant polycystic ovary syndrome single nucleotide polymorphism
其他关键词	POLYCYSTIC-OVARY-SYNDROME ; GENOME-WIDE ASSOCIATION ; ANTI-MULLERIAN HORMONE ; BREAST-CANCER ; SUSCEPTIBILITY LOCI ; INSULIN-RESISTANCE ; BINDING GLOBULIN ; LUNG-FUNCTION ; RISK ; WOMEN
摘要	Identifying etiological risk factors is significant for preventing and treating patients with polycystic ovary syndrome (PCOS). Through genetic variation, Mendelian randomization (MR) assesses causal associations between PCOS risk and related exposure factors. This emerging technology has provided evidence of causal associations of anti-Mullerian hormone (AMH) levels, sex hormone-binding globulin (SHBG) levels, menopause age, adiposity, insulin resistance (IR), depression, breast cancer, ovarian cancer, obsessive-compulsive disorder (OCD), and forced vital capacity (FVC) with PCOS, while lacking associa-tions of type 2 diabetes mellitus (T2DM), coronary heart disease (CHD), stroke, anxiety disorder (AD), schizophrenia (SCZ), bipolar disorder (BIP), and offspring birth weight with PCOS. In this review, we briefly introduce the concept and methodology of MR in terms of the opportunities and challenges in this field based on recent results obtained from MR analyses involving PCOS.
资助项目	National Natural Science Foundation of China [82001503]; China Postdoctoral Science Foundation [2021T140600, 2020M671760]; National Key Research and Development Project of China [2021YFC2700402]; CAMS Innovation Fund for Medical Sciences [2019-I2M-5-001]
出版者	ELSEVIER SCIENCE LONDON
出版地	LONDON
ISSN	0168-9525
EISSN	1362-4555
卷号	38 期号:5 页码:468-482
DOI	10.1016/j.tig.2022.01.005
页数	15
WOS类目	Genetics & Heredity
WOS研究方向	Genetics & Heredity
WOS记录号	WOS:000793468000008
收录类别	SCIE ; SCOPUS ; PUBMED
URL	查看原文
PubMed ID	35094873
SCOPUSEID	2-s2.0-85123697621
自科自定义期刊分类	T3(B)类
通讯作者地址	[Zhao, Yue]Center for Reproductive Medicine,Department of Obstetrics and Gynecology,Peking University Third Hospital,Beijing,100191,China
Scopus学科分类	Genetics
TOP期刊	TOP期刊
引用统计	被引频次：1[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/148180
专题	第一临床医学院（信息与工程学院）、附属第一医院_妇产科学_生殖医学中心附属第一医院附属第一医院_生殖医学中心
通讯作者	Zhao, Yue
作者单位	1.Reproductive Medicine Center,The First Affiliated Hospital of Wenzhou Medical University,No. 96 Fuxue Road,Wenzhou,325000,China; 2.Key Laboratory of Reproductive Genetics (Ministry of Education) and Department of Reproductive Endocrinology,Women's Hospital,Zhejiang University School of Medicine,Hangzhou,Zhejiang,310006,China; 3.Center for Reproductive Medicine,Department of Obstetrics and Gynecology,Peking University Third Hospital,Beijing,100191,China; 4.National Clinical Research Center for Obstetrics and Gynecology (Peking University Third Hospital),Beijing,100191,China; 5.Key Laboratory of Assisted Reproduction,Ministry of Education,Beijing,100191,China; 6.Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology,Beijing,100191,China; 7.Nuffield Department of Population Health,University of Oxford,UK,Oxford,OX37LF,United Kingdom
第一作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院; 生殖医学中心
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Wang, Congying,Wu, Wei,Yang, Haiyan,et al. Mendelian randomization analyses for PCOS : evidence, opportunities, and challenges[J]. TRENDS IN GENETICS,2022,38(5):468-482.
APA	Wang, Congying., Wu, Wei., Yang, Haiyan., Ye, Zhenhong., Zhao, Yue., ... & Mu, Liangshan. (2022). Mendelian randomization analyses for PCOS : evidence, opportunities, and challenges. TRENDS IN GENETICS, 38(5), 468-482.
MLA	Wang, Congying,et al."Mendelian randomization analyses for PCOS : evidence, opportunities, and challenges".TRENDS IN GENETICS 38.5(2022):468-482.