Gut Microbiota - A Potential Contributor in the Pathogenesis of Bipolar Disorder

doi:10.3389/fnins.2022.830748

科研成果详情

题名	Gut Microbiota - A Potential Contributor in the Pathogenesis of Bipolar Disorder
作者	Zhang, Peifen 1,2; Kong, Lingzhuo 1; Huang, Huimin 3; Pan, Yanmeng 1; Zhang, Danhua 1; Jiang, Jiajun 1; Shen, Yuting3; Xi, Caixi 1; Lai, Jianbo 1,2,4,5; Ng, Chee H.6; Hu, Shaohua 1,2,4,5
发表日期	2022-03-23
发表期刊	FRONTIERS IN NEUROSCIENCE 影响因子和分区
语种	英语
原始文献类型	Review
关键词	bipolar disorder gut microbiota gut-brain axis pathogenesis treatment
其他关键词	INFLAMMATORY-BOWEL-DISEASE ; BODY HABITATS ; FATTY-ACIDS ; DEPRESSION ; DOPAMINE ; HEALTH ; EXPRESSION ; MICROGLIA ; SEROTONIN ; BEHAVIOR
摘要	Bipolar disorder (BD) is one of the major psychiatric disorders that is characterized by recurrent episodes of depression and mania (or hypomania), leading to seriously adverse outcomes with unclear pathogenesis. There is an underlying relationship between bacterial communities residing in the gut and brain function, which together form the gut-brain axis (GBA). Recent studies have shown that changes in the gut microbiota have been observed in a large number of BD patients, so the axis may play a role in the pathogenesis of BD. This review summarizes briefly the relationship between the GBA and brain function, the composition and changes of gut microbiota in patients with BD, and further explores the potential role of GBA-related pathway in the pathogenesis of BD as well as the limitations in this field at present in order to provide new ideas for the future etiology research and drug development.
资助项目	National Natural Science Foundation of China [81971271]; Zhejiang Provincial Key Research and Development Program [2021C03107]; Zhejiang Provincial Natural Science Foundation [LQ20H090013]; Program from the Health and Family Planning Commission of Zhejiang Province [2020KY548]
出版者	FRONTIERS MEDIA SA
出版地	LAUSANNE
ISSN	1662-4548
EISSN	1662-453X
卷号	16 页码:830748
DOI	10.3389/fnins.2022.830748
页数	13
WOS类目	Neurosciences
WOS研究方向	Neurosciences & Neurology
WOS记录号	WOS:000781416800001
收录类别	SCIE ; SCOPUS ; SSCI ; PUBMED
URL	查看原文
PubMed ID	35401095
SCOPUSEID	2-s2.0-85128161768
通讯作者地址	[Hu, Shaohua]Department of Psychiatry,The First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou,China ; [Ng, Chee H.]Department of Psychiatry,The Melbourne Clinic and St Vincent’s Hospital,University of Melbourne,Richmond,Australia
Scopus学科分类	Neuroscience (all)
引用统计	被引频次[WOS]：0 [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/148137
专题	精神医学学院_精神医学系第一临床医学院（信息与工程学院）、附属第一医院_精神病与精神卫生学
通讯作者	Ng, Chee H.; Hu, Shaohua
作者单位	1.Department of Psychiatry,The First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou,China; 2.MOE Frontier Science Center for Brain Science and Brain-Machine Integration,Zhejiang University,Hangzhou,China; 3.Department of Psychiatry,Wenzhou Medical University,Wenzhou,China; 4.The Key Laboratory of Mental Disorder Management in Zhejiang Province,Hangzhou,China; 5.Brain Research Institute,Zhejiang University,Hangzhou,China; 6.Department of Psychiatry,The Melbourne Clinic and St Vincent’s Hospital,University of Melbourne,Richmond,Australia
推荐引用方式 GB/T 7714	Zhang, Peifen,Kong, Lingzhuo,Huang, Huimin,et al. Gut Microbiota - A Potential Contributor in the Pathogenesis of Bipolar Disorder[J]. FRONTIERS IN NEUROSCIENCE,2022,16:830748.
APA	Zhang, Peifen., Kong, Lingzhuo., Huang, Huimin., Pan, Yanmeng., Zhang, Danhua., ... & Hu, Shaohua. (2022). Gut Microbiota - A Potential Contributor in the Pathogenesis of Bipolar Disorder. FRONTIERS IN NEUROSCIENCE, 16, 830748.
MLA	Zhang, Peifen,et al."Gut Microbiota - A Potential Contributor in the Pathogenesis of Bipolar Disorder".FRONTIERS IN NEUROSCIENCE 16(2022):830748.