Prognostic factors of severe pneumonia in patients treated with rituximab in the intensive care unit

doi:10.1177/03000605211063281

科研成果详情

题名	Prognostic factors of severe pneumonia in patients treated with rituximab in the intensive care unit
作者	Yao, Lili 1; Huang, Yu2; Xu, Andi 3
发表日期	2022-03
发表期刊	JOURNAL OF INTERNATIONAL MEDICAL RESEARCH 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Severe pneumonia rituximab prognostic factor underlying condition mechanical ventilation intensive care unit
其他关键词	COMMUNITY-ACQUIRED PNEUMONIA ; INFECTIONS ; THERAPY ; GUIDELINES ; RISK
摘要	Objective The aim of this study was to describe the clinical characteristics and prognostic factors of patients treated with rituximab (RTX) who developed severe pneumonia in the intensive care unit (ICU). Methods We systematically reviewed the medical records of 40 patients who received RTX and developed severe pneumonia in the ICU at our hospital from January 2009 to January 2019 to evaluate the underlying conditions, clinical course, and possible prognostic factors. Results Most patients had underlying hematologic malignancies (n = 21, 52.5%), followed by rheumatologic diseases (n = 17, 42.5%). The most frequent causative pathogens were fungi (n = 11, 27.5%), followed by bacteria (n = 9, 22.5%) and Pneumocystis jirovecii pneumonia (n = 8, 20%). Thirty patients (75%) died, and the other 10 patients (25%) survived. Compared with survivors, patients who died were significantly older (60.6 +/- 10.6 vs 44.4 +/- 18.3 years) and had chronic lung disease (40% vs 0%). Conclusion Older age and chronic lung disease were significantly associated with mortality in patients treated with RTX.
资助项目	National Science Foundation of Zhejiang [LQ17H030005]; Wenzhou Committee of Science and Technology of China [2020Y1148]
出版者	SAGE PUBLICATIONS LTD
出版地	LONDON
ISSN	0300-0605
EISSN	1473-2300
卷号	50 期号:3 页码:3000605211063281
DOI	10.1177/03000605211063281
页数	7
WOS类目	Medicine, Research & Experimental ; Pharmacology & Pharmacy
WOS研究方向	Research & Experimental Medicine ; Pharmacology & Pharmacy
WOS记录号	WOS:000777496300001
收录类别	SCIE ; SCOPUS ; PUBMED
URL	查看原文
PubMed ID	35350908
SCOPUSEID	2-s2.0-85127222834
通讯作者地址	[Huang, Yu]Department of Infectious Diseases,First Affiliated Hospital of Wenzhou Medical University,Zhejiang,Wenzhou,China ; [Xu, Andi]Department of Rheumatology,Lishui central hospital,Lishui hospital of Zhejiang University,Fifth Affiliated Hospital,Wenzhou Medical University,Lishui,China
Scopus学科分类	Biochemistry;Cell Biology;Biochemistry (medical)
引用统计	被引频次[WOS]：0 [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/148106
专题	附属第一医院其他_附属第五医院（丽水市中心医院）
通讯作者	Huang, Yu; Xu, Andi
作者单位	1.Department of Nephrology,Lishui Central Hospital,Lishui Hospital of Zhejiang University,Fifth Affiliated Hospital of Wenzhou University,Lishui,China; 2.Department of Infectious Diseases,First Affiliated Hospital of Wenzhou Medical University,Zhejiang,Wenzhou,China; 3.Department of Rheumatology,Lishui central hospital,Lishui hospital of Zhejiang University,Fifth Affiliated Hospital,Wenzhou Medical University,Lishui,China
通讯作者单位	附属第一医院; 附属第五医院（丽水市中心医院）
推荐引用方式 GB/T 7714	Yao, Lili,Huang, Yu,Xu, Andi. Prognostic factors of severe pneumonia in patients treated with rituximab in the intensive care unit[J]. JOURNAL OF INTERNATIONAL MEDICAL RESEARCH,2022,50(3):3000605211063281.
APA	Yao, Lili, Huang, Yu, & Xu, Andi. (2022). Prognostic factors of severe pneumonia in patients treated with rituximab in the intensive care unit. JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, 50(3), 3000605211063281.
MLA	Yao, Lili,et al."Prognostic factors of severe pneumonia in patients treated with rituximab in the intensive care unit".JOURNAL OF INTERNATIONAL MEDICAL RESEARCH 50.3(2022):3000605211063281.