Down-regulation of miRNA-30a in human plasma is a novel marker for breast cancer

doi:10.1007/s12032-013-0477-z

科研成果详情

题名	Down-regulation of miRNA-30a in human plasma is a novel marker for breast cancer
作者	Zeng, Rui-chao; Zhang, Wei; Yan, Xing-qiang; Ye, Zhi-qiang; Chen, En-dong; Huang, Du-ping; Zhang, Xiao-hua; Huang, Guan-li
发表日期	2013-03
发表期刊	MEDICAL ONCOLOGY 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Breast cancer MicroRNAs miRNA-30a Plasma Tumor maker
其他关键词	CIRCULATING MICRORNAS ; COLORECTAL-CANCER ; PROSTATE-CANCER ; SERUM ; EXPRESSION ; CARCINOMA ; MIR-21 ; HETEROZYGOSITY ; MAMMOGRAPHY ; BIOMARKERS
摘要	The present study was to evaluate the value of miRNA-30a in plasma as potential tumor marker in detecting breast cancer (BC). Using a novel approach to extract miRNA-30a from the plasma followed by real-time quantitative polymerase chain reaction (RQ-PCR) analysis, levels of miRNA-30a were quantified in plasma specimens of 100 BCs and 64 age-matched and disease-free healthy controls (HC). And we compared the diagnostic value of plasma miRNA-30a with conventional circulating tumor markers CA153 and CEA. The median levels of miRNA-30a were significantly lower in preoperative BC than those in HC (P < 0.001). The levels of CEA and CA153 were all significantly higher in preoperative BC compared with those in HC (P = 0.008 and P = 0.001, respectively), and only the level of CA153 decreased in postoperative BC compared with preoperative BC (P = 0.015). ROC analysis showed the sensitivity and specificity of miRNA-30a for BC diagnosis at 74.0 and 65.6 %, respectively, whereas the sensitivities of CEA and CA153 were 12.0 and 14.0 %, respectively. The status of ER and triple-negative BC was significantly associated with miRNA-30a level (P = 0.007 and P = 0.005, respectively). And no other clinicopathological features were found to had significant difference. Our findings suggest that plasma miRNA-30a decreased in patients with BC and has great potential to use as novel biomarkers for BC diagnosis.
资助项目	Wenzhou Science and Technology Bureau [Y20100008, Y20080081]; Health Bureau of Zhejiang Province [2009B106]
出版者	HUMANA PRESS INC
出版地	TOTOWA
ISSN	1357-0560
EISSN	1559-131X
卷号	30 期号:1 页码:477
DOI	10.1007/s12032-013-0477-z
页数	8
WOS类目	Oncology
WOS研究方向	Oncology
WOS记录号	WOS:000316800800151
收录类别	SCIE ; PUBMED
URL	查看原文
PubMed ID	23389917
通讯作者地址	[Huang, Guan-li]Wenzhou Med Coll, Dept Surg Oncol, Affiliated Hosp 1, 2 Fu Xue Rd, Wenzhou City 325000, Zhejiang, Peoples R China.
引用统计	被引频次：64[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/1478
专题	第一临床医学院（信息与工程学院）、附属第一医院_外科学_肿瘤外科附属第一医院
通讯作者	Huang, Guan-li
作者单位	Wenzhou Med Coll, Dept Surg Oncol, Affiliated Hosp 1, Wenzhou City 325000, Zhejiang, Peoples R China
第一作者单位	附属第一医院; 肿瘤外科
通讯作者单位	附属第一医院; 肿瘤外科
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Zeng, Rui-chao,Zhang, Wei,Yan, Xing-qiang,et al. Down-regulation of miRNA-30a in human plasma is a novel marker for breast cancer[J]. MEDICAL ONCOLOGY,2013,30(1):477.
APA	Zeng, Rui-chao., Zhang, Wei., Yan, Xing-qiang., Ye, Zhi-qiang., Chen, En-dong., ... & Huang, Guan-li. (2013). Down-regulation of miRNA-30a in human plasma is a novel marker for breast cancer. MEDICAL ONCOLOGY, 30(1), 477.
MLA	Zeng, Rui-chao,et al."Down-regulation of miRNA-30a in human plasma is a novel marker for breast cancer".MEDICAL ONCOLOGY 30.1(2013):477.