Sex-influenced association of non-alcoholic fatty liver disease with colorectal adenomatous and hyperplastic polyps

doi:10.3748/wjg.v23.i28.5206

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题名	Sex-influenced association of non-alcoholic fatty liver disease with colorectal adenomatous and hyperplastic polyps
作者	Chen, Qin-Fen1; Zhou, Xiao-Dong2; Sun, Yang-Jie 1; Fang, Dan-Hong3; Zhao, Qian1; Huang, Jun-Hua 1; Jin, Yin1; Wu, Jian-Sheng3
发表日期	2017-07-28
发表期刊	WORLD JOURNAL OF GASTROENTEROLOGY 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Non-alcoholic fatty liver disease Health-check Adenomatous polyps Hyperplastic polyps
其他关键词	INSULIN-RESISTANCE ; METABOLIC SYNDROME ; FOLLOW-UP ; NAFLD ; RISK ; CHINESE ; PREVALENCE ; DYSLIPIDEMIA ; ADIPONECTIN ; ONCOPROTEIN
摘要	AIM To investigate the relationship between non-alcoholic fatty liver disease (NAFLD) and colorectal adenomatous and hyperplastic polyps. METHODS A retrospective cross-sectional study was conducted on 3686 individuals undergoing health checkups (2430 males and 1256 females). All subjects underwent laboratory testing, abdominal ultrasonography, colono-scopy, and an interview to ascertain the baseline characteristics and general state of health. Multinomial logistic regression analysis was performed to examine the association between NAFLD and the prevalence of colorectal adenomatous and hyperplastic polyps. Furthermore, the relationship was analyzed in different sex groups. Subgroup analysis was performed based on number, size, and location of colorectal polyps. RESULTS The prevalence of colorectal polyps was 38.8% in males (16.2% for adenomatous polyps and 9.8% for hyperplastic polyps) and 19.3% in females (8.4% for adenomatous polyps and 3.9% for hyperplastic polyps). When adjusting for confounding variables, NAFLD was significantly associated with the prevalence of adenomatous polyps (OR = 1.28, 95% CI: 1.05-1.51, P < 0.05) and hyperplastic polyps (OR = 1.35, 95% CI: 1.01-1.82, P < 0.05). However, upon analyzing adenomatous and hyperplastic polyps in different sex groups, the significant association remained in males (OR = 1.53, 95% CI: 1.18-2.00, P < 0.05; OR = 1.42, 95% CI: 1.04-1.95, P < 0.05) but not in females (OR = 0.44, 95% CI: 0.18-1.04, P > 0.05; OR = 1.18, 95% CI: 0.50-2.78, P > 0.05). CONCLUSION NAFLD is specifically associated with an increased risk of colorectal adenomatous and hyperplastic polyps in men. However, NAFLD may not be a significant factor in the prevalence of colorectal polyps in women.
出版者	BAISHIDENG PUBLISHING GROUP INC
出版地	PLEASANTON
ISSN	1007-9327
EISSN	2219-2840
卷号	23 期号:28 页码:5206-5215
DOI	10.3748/wjg.v23.i28.5206
页数	10
WOS类目	Gastroenterology & Hepatology
WOS研究方向	Gastroenterology & Hepatology
WOS记录号	WOS:000407559600015
收录类别	SCIE ; PUBMED ; 万方 ; SCOPUS
URL	查看原文
PubMed ID	28811715
PMC记录号	PMC5537187
SCOPUSEID	2-s2.0-85026556612
通讯作者地址	[Wu, Jian-Sheng]MeDical and Health Care Center,First Affiliated Hospital of Wenzhou MeDical University,Xinyuan District, Wenzhou, Zhejiang Province,325000,China
Scopus学科分类	Gastroenterology
引用统计	被引频次：19[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/14704
专题	附属第一医院第一临床医学院（信息与工程学院）、附属第一医院_医疗保健中心
通讯作者	Wu, Jian-Sheng
作者单位	1.Department of Gastroenterology,First Affiliated Hospital of Wenzhou MeDical University,Wenzhou, Zhejiang Province,325000,China; 2.Department of CarDiovascular MeDicine,First Affiliated Hospital of Wenzhou MeDical University,Wenzhou, Zhejiang Province,325000,China; 3.MeDical and Health Care Center,First Affiliated Hospital of Wenzhou MeDical University,Xinyuan District, Wenzhou, Zhejiang Province,325000,China
第一作者单位	附属第一医院
通讯作者单位	附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Chen, Qin-Fen,Zhou, Xiao-Dong,Sun, Yang-Jie,et al. Sex-influenced association of non-alcoholic fatty liver disease with colorectal adenomatous and hyperplastic polyps[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2017,23(28):5206-5215.
APA	Chen, Qin-Fen., Zhou, Xiao-Dong., Sun, Yang-Jie., Fang, Dan-Hong., Zhao, Qian., ... & Wu, Jian-Sheng. (2017). Sex-influenced association of non-alcoholic fatty liver disease with colorectal adenomatous and hyperplastic polyps. WORLD JOURNAL OF GASTROENTEROLOGY, 23(28), 5206-5215.
MLA	Chen, Qin-Fen,et al."Sex-influenced association of non-alcoholic fatty liver disease with colorectal adenomatous and hyperplastic polyps".WORLD JOURNAL OF GASTROENTEROLOGY 23.28(2017):5206-5215.

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