Atorvastatin ameliorates depressive behaviors and neuroinflammatory in streptozotocin-induced diabetic mice

doi:10.1007/s00213-019-05406-w

科研成果详情

题名	Atorvastatin ameliorates depressive behaviors and neuroinflammatory in streptozotocin-induced diabetic mice
作者	Hai-Na, Zhang 1,2; Xu-Ben, Yu 1,2; Cong-Rong, Tang 1,2; Yan-Cheng, Cao 2; Fan, Yang 2; Lei-Mei, Xu 2; Ruo-Lan, Sun 2; Ye-Zi 2; Ye-Xuan, Wang 2; Jing, Liang 1,2
发表日期	2020-03
发表期刊	PSYCHOPHARMACOLOGY 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Atorvastatin Streptozotocin Depression Diabetes Neuroinflammation
其他关键词	CHRONIC MILD STRESS ; DOUBLE-BLIND ; SIMVASTATIN ; INFLAMMATION ; STATINS ; DISORDER ; PATHOPHYSIOLOGY ; PLACEBO ; ANXIETY ; DISEASE
摘要	Depression is a chronic and progressive syndrome and commonly associated with several neuropsychiatric comorbidities, of which depression is the most studied. It has been demonstrated that statins also have anti-inflammatory and immunomodulatory properties, which being explored for potential benefits in depression. However, the role of statins in the treatment of diabetes-related depression has not been well examined. Herein, we investigated the effects of atorvastatin on depressive behaviors and neuroinflammation in streptozotocin-induced diabetic mice. Our data indicated that oral administration of atorvastatin at 10 or 20 mg/kg for 3 weeks markedly ameliorated diabetes-associated depressive behaviors reflected by better performance in sucrose preference test (SPT), tail suspension test (TST), and novelty-suppressed feeding test (NSFT). The study further showed that atrovastatin decreased the expression of nucleus NF-kappa B p65 expression and ameliorated neuroinflammatory responses in prefrontal cortex as evidenced by less Iba-1-positive cells and lower inflammatory mediators including IL-1 beta and TNF-alpha. As expected, atorvastatin-treated diabetic mice exhibited significant improvement of hyperlipidemia rather than hyperglycemia. These results suggest that atorvastatin has the potential to be employed as a therapy for diabetes-related depression.
资助项目	Science Foundation of the Zhejiang Pharmaceutical Association [2018ZYY43, 2017ZYY20]; Science Foundation of Wenzhou [S20100050]
出版者	SPRINGER
出版地	NEW YORK
ISSN	0033-3158
EISSN	1432-2072
卷号	237 期号:3 页码:695-705
DOI	10.1007/s00213-019-05406-w
页数	11
WOS类目	Neurosciences ; Pharmacology & Pharmacy ; Psychiatry
WOS研究方向	Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
WOS记录号	WOS:000499561500002
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	31786648
SCOPUSEID	2-s2.0-85075765925
通讯作者地址	[Jing, Liang]Department of Pharmacy,Wenzhou Medical University,Wenzhou,325000,China
Scopus学科分类	Pharmacology
引用统计	被引频次：9[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/14659
专题	附属第一医院药学院（分析测试中心）_药学系
通讯作者	Jing, Liang
作者单位	1.Department of Pharmacy,Zhejiang Provincial Key Laboratory of Aging and Neurological Disorder Research,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China; 2.Department of Pharmacy,Wenzhou Medical University,Wenzhou,325000,China
第一作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院; 温州医科大学
通讯作者单位	温州医科大学
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Hai-Na, Zhang,Xu-Ben, Yu,Cong-Rong, Tang,et al. Atorvastatin ameliorates depressive behaviors and neuroinflammatory in streptozotocin-induced diabetic mice[J]. PSYCHOPHARMACOLOGY,2020,237(3):695-705.
APA	Hai-Na, Zhang., Xu-Ben, Yu., Cong-Rong, Tang., Yan-Cheng, Cao., Fan, Yang., ... & Jing, Liang. (2020). Atorvastatin ameliorates depressive behaviors and neuroinflammatory in streptozotocin-induced diabetic mice. PSYCHOPHARMACOLOGY, 237(3), 695-705.
MLA	Hai-Na, Zhang,et al."Atorvastatin ameliorates depressive behaviors and neuroinflammatory in streptozotocin-induced diabetic mice".PSYCHOPHARMACOLOGY 237.3(2020):695-705.