Oxidative Stress-Related Biomarkers in Postmenopausal Osteoporosis: A Systematic Review and Meta-Analyses

doi:10.1155/2016/7067984

科研成果详情

题名	Oxidative Stress-Related Biomarkers in Postmenopausal Osteoporosis: A Systematic Review and Meta-Analyses
作者	Zhou, Qiaozhen 1; Zhu, Li 1; Zhang, Dafeng1; Li, Ning1; Li, Qiao2; Dai, Panpan1,3; Mao, Yixin1,3; Li, Xumin 1,3; Ma, Jianfeng1,3; Huang, Shengbin1,3
发表日期	2016-12-31
发表期刊	DISEASE MARKERS 影响因子和分区
语种	英语
原始文献类型	Review
其他关键词	BONE-MINERAL DENSITY ; NITRIC-OXIDE ; HOMOCYSTEINE LEVELS ; OSTEOBLASTIC DIFFERENTIATION ; LIPID-PEROXIDATION ; FRACTURE RISK ; HIP FRACTURE ; FOLATE ; WOMEN ; ASSOCIATION
摘要	Numerous studies suggested that oxidative stress (OS) played a central role in the onset and development of postmenopausal osteoporosis (PO); however, conflicting results were obtained as to the association of OS-related biomarkers and PO. This meta-analysis aimed to identify the association between these markers and PO, and explore factors that may explain the inconsistencies in these results. A systematic literature search was conducted in relevant database. Search terms and selection criteria were priorly determined to identify and include all studies that detected markers of OS in PO patients. We pooled data with a random effects meta-analysis with standardized mean differences and 95% confidence interval. Total 17 studies including 12 OS markers were adopted. The results showed that superoxide dismutase (SOD) in erythrocytes, catalase (CAT), total antioxidant status (TAS), hydroperoxides (HY), advanced oxidation protein products (AOPP), malondialdehyde (MDA), and vitamin B12 (VB12) in plasma/serum were not statistically different between the PO and control group, whereas significantly increased level of homocysteine (Hcy) and nitric oxide (NO), along with decreased SOD, glutathione peroxidase (GPx), folate, and total antioxidant power (TAP) in plasma/serum were obtained in the PO group. In summary, OS might serve as potential biomarkers in the etiopathophysiology and clinical course of PO.
资助项目	Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81271186, 81500817]; Zhejiang Provincial Natural Science Foundation of ChinaNatural Science Foundation of Zhejiang Province [LY15H140008]; Health Science and Technology Project of Zhejiang Province [2016KYB184]; Wenzhou Public Technical Research Medical Program [Y20140708]
出版者	HINDAWI LTD
出版地	LONDON
ISSN	0278-0240
EISSN	1875-8630
卷号	2016 页码:7067984
DOI	10.1155/2016/7067984
页数	12
WOS类目	Biotechnology & Applied Microbiology ; Genetics & Heredity ; Medicine, Research & Experimental ; Pathology
WOS研究方向	Biotechnology & Applied Microbiology ; Genetics & Heredity ; Research & Experimental Medicine ; Pathology
WOS记录号	WOS:000382047900001
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	27594735
PMC记录号	PMC4995322
SCOPUSEID	2-s2.0-84983782699
通讯作者地址	[Ma, Jianfeng]Department of Prosthodontics,School and Hospital of Stomatology,Wenzhou Medical University,Wenzhou,325027,China
Scopus学科分类	Molecular Biology;Genetics;Clinical Biochemistry;Biochemistry (medical)
引用统计	被引频次：93[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/14559
专题	口腔医学院、附属口腔医院口腔医学院、附属口腔医院_口腔医学研究所口腔医学院、附属口腔医院_儿童口腔
通讯作者	Ma, Jianfeng
作者单位	1.Department of Prosthodontics,School and Hospital of Stomatology,Wenzhou Medical University,Wenzhou,325027,China; 2.Department of Pediatric Dentistry,School and Hospital of Stomatology,Wenzhou Medical University,Wenzhou,325027,China; 3.Institute of Stomatology,School and Hospital of Stomatology,Wenzhou Medical University,Wenzhou,325027,China
第一作者单位	口腔医学院、附属口腔医院
通讯作者单位	口腔医学院、附属口腔医院
第一作者的第一单位	口腔医学院、附属口腔医院
推荐引用方式 GB/T 7714	Zhou, Qiaozhen,Zhu, Li,Zhang, Dafeng,et al. Oxidative Stress-Related Biomarkers in Postmenopausal Osteoporosis: A Systematic Review and Meta-Analyses[J]. DISEASE MARKERS,2016,2016:7067984.
APA	Zhou, Qiaozhen., Zhu, Li., Zhang, Dafeng., Li, Ning., Li, Qiao., ... & Huang, Shengbin. (2016). Oxidative Stress-Related Biomarkers in Postmenopausal Osteoporosis: A Systematic Review and Meta-Analyses. DISEASE MARKERS, 2016, 7067984.
MLA	Zhou, Qiaozhen,et al."Oxidative Stress-Related Biomarkers in Postmenopausal Osteoporosis: A Systematic Review and Meta-Analyses".DISEASE MARKERS 2016(2016):7067984.