Diagnostic value of complete blood count in paraquat and organophosphorus poisoning patients

doi:10.1177/0748233718770896

科研成果详情

题名	Diagnostic value of complete blood count in paraquat and organophosphorus poisoning patients
作者	Tang, Yahui1; Hu, Lufeng2; Hong, Guangliang1; Zhong, Dahai 1; Song, Jiaxing 1; Zhao, Guangju1; Lu, Zhongqiu1
发表日期	2018-07
发表期刊	TOXICOLOGY AND INDUSTRIAL HEALTH 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Complete blood count paraquat organophosphorus prognosis patients
其他关键词	SUPPORT VECTOR MACHINE ; HERBICIDES PARAQUAT ; METABOLIC-CHANGES ; URINE SAMPLES ; CELL COUNT ; PLASMA ; PARAMETERS ; PROGNOSIS ; INFECTION ; DISEASE
摘要	Complete blood count (CBC) is one of the most extensively used tests in clinical practice. In order to determine the diagnostic value of the CBC in paraquat (PQ) and organophosphorus (OPPs) poisoning, the CBC indices of PQ- and OPPs-poisoned patients were investigated in this study. A total of 96 PQ poisoning patients, 90 OPPs poisoning patients, and 188 healthy subjects were included in this study. The PQ- and OPPs-poisoned patients were divided into different groups according to their clinical symptoms. All CBC indices were analyzed by Fisher discriminant, partial least-squares discriminant analysis (PLS-DA), variance analysis, and receiver operating characteristic (ROC). The discriminant results showed that 87.7% of original grouped cases correctly classified between PQ-poisoned patients, OPPs-poisoned patients, and healthy subjects. The PLS-DA results showed that the important variable order was different in PQ- and OPPs-poisoned patients. Both white blood cell (WBC) and neutrophil (NE) counts were the most important indexes in PQ- and OPPs-poisoned patients. In OPPs poisoning patients, WBC and NE showed statistical differences between the severe poisoning group and the moderate poisoning group. Their areas under the ROC curve (AUC) were 0.673 (WBC) and 0.669 (NE), which were higher than cholinesterase (CHE; AUC 0.326). In conclusion, the CBC indices had a diagnostic value in PQ and OPPs poisoning; WBC and NE were the first responses and had clinical significance in PQ and OPPs poisoning; moreover, they are better than CHE in diagnosing OPPs poisoning.
资助项目	Science and Technology Program Project Funds of Wenz-hou[Y20140673];Natural Science Foundation of Zhejiang Province[LY16H300005];Health Department of Zhejiang Province[2015KYA154];key construction academic subject[11-CX26];
出版者	SAGE PUBLICATIONS INC
出版地	THOUSAND OAKS
ISSN	0748-2337
EISSN	1477-0393
卷号	34 期号:7 页码:439-447
DOI	10.1177/0748233718770896
页数	9
WOS类目	Public, Environmental & Occupational Health ; Toxicology
WOS研究方向	Public, Environmental & Occupational Health ; Toxicology
WOS记录号	WOS:000433617800001
收录类别	SCIE ; SCOPUS ; PUBMED
URL	查看原文
PubMed ID	29669481
SCOPUSEID	2-s2.0-85047962718
通讯作者地址	[Lu, Zhongqiu]Department of Emergency,The First Affiliated Hospital of Wenzhou Medical University,Ouhai District,Wenzhou,325000,China
Scopus学科分类	Toxicology;Public Health, Environmental and Occupational Health;Health, Toxicology and Mutagenesis
引用统计	被引频次：9[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/14511
专题	附属第一医院_急诊科附属第一医院_药学部药学部
通讯作者	Lu, Zhongqiu
作者单位	1.Department of Emergency,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China; 2.Department of Pharmacy,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China
第一作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
通讯作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Tang, Yahui,Hu, Lufeng,Hong, Guangliang,et al. Diagnostic value of complete blood count in paraquat and organophosphorus poisoning patients[J]. TOXICOLOGY AND INDUSTRIAL HEALTH,2018,34(7):439-447.
APA	Tang, Yahui., Hu, Lufeng., Hong, Guangliang., Zhong, Dahai., Song, Jiaxing., ... & Lu, Zhongqiu. (2018). Diagnostic value of complete blood count in paraquat and organophosphorus poisoning patients. TOXICOLOGY AND INDUSTRIAL HEALTH, 34(7), 439-447.
MLA	Tang, Yahui,et al."Diagnostic value of complete blood count in paraquat and organophosphorus poisoning patients".TOXICOLOGY AND INDUSTRIAL HEALTH 34.7(2018):439-447.