Immune Infiltration Landscape in Lung Squamous Cell Carcinoma Implications

doi:10.1155/2020/5981870

科研成果详情

题名	Immune Infiltration Landscape in Lung Squamous Cell Carcinoma Implications
作者	Zhao, Jungang1; Bao, Wenming1; Cai, Weiyang2
发表日期	2020-10-10
发表期刊	BIOMED RESEARCH INTERNATIONAL 影响因子和分区
语种	英语
原始文献类型	Article
其他关键词	MUTANT P53 ; T-CELLS ; CANCER ; EXPRESSION ; MUTATIONS ; THERAPY ; GAIN ; DOCETAXEL ; PROGNOSIS ; NIVOLUMAB
摘要	Intrinsic cancer cells and the tumor-infiltrating immune cells (TIICs) recruited to the immune microenvironment define the malignant phenotype of lung squamous cell carcinoma (LUSC). Understanding more about the immune microenvironment of LUSC enables the selection of high-risk patients who would derive benefit from immunotherapy. Based on large public LUSC cohorts obtained from TCGA and GEO datasets, 22 types of infiltrating immune cell subgroups were evaluated by CIBERSORT. Meta-analysis, principal component analysis (PCA), single-sample gene set enrichment analysis (ssGSEA), and hierarchical clustering analysis were used to evaluate specific immune responses of LUSC. The distribution of TIICs of LUSC was entirely different from normal. TIIC subpopulations were also found to be closely associated with clinical features and molecular subtypes. Unsupervised clustering analysis revealed that three distinct TIIC subgroups existed with different survival patterns. TIICs are extensively implicated in the pathogenesis and development of LUSC. Characterizing the composition of TIICs influences the metabolism, pathological stage, and survival of tumor patients. It is hoped that this immune landscape could provide a more accurate understanding of the development and immunotherapy of LUSC.
资助项目	National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81703310]; Scientific Research Foundation of the First Affiliated Hospital of Wenzhou Medical University [FHY2019002]
出版者	HINDAWI LTD
出版地	LONDON
ISSN	2314-6133
EISSN	2314-6141
卷号	2020 页码:5981870
DOI	10.1155/2020/5981870
页数	21
WOS类目	Biotechnology & Applied Microbiology ; Medicine, Research & Experimental
WOS研究方向	Biotechnology & Applied Microbiology ; Research & Experimental Medicine
WOS记录号	WOS:000585705900001
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	33102584
PMC记录号	PMC7569448
SCOPUSEID	2-s2.0-85094633529
通讯作者地址	[Cai, Weiyang]Department of Gastroenterology,First Affiliated Hospital,Wenzhou Medical University,Wenzhou,China
Scopus学科分类	Immunology and Microbiology (all);Biochemistry, Genetics and Molecular Biology (all)
引用统计	被引频次：5[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/14467
专题	附属第一医院_肝胆外科附属第一医院
通讯作者	Cai, Weiyang
作者单位	1.Department of Hepatobiliary Surgery,First Affiliated Hospital,Wenzhou Medical University,Wenzhou,China; 2.Department of Gastroenterology,First Affiliated Hospital,Wenzhou Medical University,Wenzhou,China
第一作者单位	附属第一医院
通讯作者单位	附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Zhao, Jungang,Bao, Wenming,Cai, Weiyang. Immune Infiltration Landscape in Lung Squamous Cell Carcinoma Implications[J]. BIOMED RESEARCH INTERNATIONAL,2020,2020:5981870.
APA	Zhao, Jungang, Bao, Wenming, & Cai, Weiyang. (2020). Immune Infiltration Landscape in Lung Squamous Cell Carcinoma Implications. BIOMED RESEARCH INTERNATIONAL, 2020, 5981870.
MLA	Zhao, Jungang,et al."Immune Infiltration Landscape in Lung Squamous Cell Carcinoma Implications".BIOMED RESEARCH INTERNATIONAL 2020(2020):5981870.