Low serum 25-hydroxyvitamin D concentrations in chronic insomnia patients and the association with poor treatment outcome at 2 months

doi:10.1016/j.cca.2017.10.024

科研成果详情

题名	Low serum 25-hydroxyvitamin D concentrations in chronic insomnia patients and the association with poor treatment outcome at 2 months
作者	Zhao, Kai; Luan, Xiaoqian; Liu, Yuntao; Tu, Xinjie; Chen, Huijun; Shen, Huiping; Qiu, Huihua; Zhu, Zhuoying; He, Jincai
发表日期	2017-12
发表期刊	CLINICA CHIMICA ACTA 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Chronic insomnia Vitamin D Outcome
其他关键词	VITAMIN-D ; SLEEP MEDICINE ; ADULTS ; NEUROBIOLOGY ; METABOLISM ; APNEA
摘要	Background: The association between low 25-hydroxyvitamin D [25(OH)D) and sleep disorder has been reported. We investigated whether serum concentrations of 25(OH)D are altered in chronic insomnia patients. The relationship between serum concentrations of 25(OH)D and the treatment outcome in patients at 2 months was also investigated. Methods: In total, 181 chronic insomnia patients were consecutively recruited. All patients received pharmacotherapy for the treatment of chronic insomnia. Serum 25(OH)D concentrations were quantified by a competitive electrochemiluminescence protein binding assay. Treatment outcomes were defined as response versus non-response, according to the change of the Pittsburgh Sleep Quality Index (PSQI). We also recruited 100 healthy subjects as a control group. Results: Fifty-four out of 181 (29.8%) patients met the criteria for non-response. Chronic insomnia patients had significantly lower 25(OH)D concentrations compared with healthy controls (23.01 +/- 9.18 vs 27.17 +/- 6.41 ng/ml, P < 0.001). Non-response patients also had significantly lower 25(OH)D concentrations than those with response. Vitamin D deficiency(25(OH)D concentrations < 20 ng/ml) was independently associated with a higher probability of treatment non-response at 2 months (odds ratio 11.636, 95% confidence interval 3.966-34.142, P < 0.001). Conclusions: Measurement of serum 25(OH)D concentrations are probably useful for judging treatment outcomes of pharmacotherapy in chronic insomnia patients.
资助项目	Wenzhou Municipal Sci-Tech Bureau Program [Y20160002]; National Key Technology Research and Development Program of the Ministry of Science and Technology of the People's Republic of China [2015BA113B01]
出版者	ELSEVIER SCIENCE BV
出版地	AMSTERDAM
ISSN	0009-8981
EISSN	1873-3492
卷号	475 页码:147-151
DOI	10.1016/j.cca.2017.10.024
页数	5
WOS类目	Medical Laboratory Technology
WOS研究方向	Medical Laboratory Technology
WOS记录号	WOS:000417666800022
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	29080688
SCOPUSEID	2-s2.0-85032362002
通讯作者地址	[He, Jincai]Department of Neurology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China
Scopus学科分类	Biochemistry;Clinical Biochemistry;Biochemistry (medical)
引用统计	被引频次：8[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/1432
专题	第一临床医学院（信息与工程学院）、附属第一医院_内科学_神经内科
通讯作者	He, Jincai
作者单位	Department of Neurology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China
第一作者单位	第一临床医学院（信息与工程学院）、附属第一医院_内科学_神经内科
通讯作者单位	第一临床医学院（信息与工程学院）、附属第一医院_内科学_神经内科
第一作者的第一单位	第一临床医学院（信息与工程学院）、附属第一医院_内科学_神经内科
推荐引用方式 GB/T 7714	Zhao, Kai,Luan, Xiaoqian,Liu, Yuntao,et al. Low serum 25-hydroxyvitamin D concentrations in chronic insomnia patients and the association with poor treatment outcome at 2 months[J]. CLINICA CHIMICA ACTA,2017,475:147-151.
APA	Zhao, Kai., Luan, Xiaoqian., Liu, Yuntao., Tu, Xinjie., Chen, Huijun., ... & He, Jincai. (2017). Low serum 25-hydroxyvitamin D concentrations in chronic insomnia patients and the association with poor treatment outcome at 2 months. CLINICA CHIMICA ACTA, 475, 147-151.
MLA	Zhao, Kai,et al."Low serum 25-hydroxyvitamin D concentrations in chronic insomnia patients and the association with poor treatment outcome at 2 months".CLINICA CHIMICA ACTA 475(2017):147-151.