The effects of changes in platelet-to-neutrophil ratios 24 hours after intravenous thrombolysis on prognosis in acute ischemic stroke patients

doi:10.1016/j.clineuro.2020.105739

科研成果详情

题名	The effects of changes in platelet-to-neutrophil ratios 24 hours after intravenous thrombolysis on prognosis in acute ischemic stroke patients
作者	Pan, Hong 1; Fu, Mei 1; Ge, Wanqian 2; Zhou, Chengye2
发表日期	2020-03
发表期刊	CLINICAL NEUROLOGY AND NEUROSURGERY 影响因子和分区
语种	英语
原始文献类型	Article
关键词	PNR 24h PNR Acute ischemic stroke Prognosis Intravenous thrombolysis
其他关键词	ELEVATION MYOCARDIAL-INFARCTION ; NO-REFLOW PHENOMENON
摘要	Objective: To investigate the prognostic value of Platelet-to-Neutrophil ratio on admission (PNR on admission) and 24 h after intravenous thrombolysis (24 h PNR) in acute ischemic stroke patients (AIS) patients. Patients and Methods: One hundred fifty-one ischemic stroke patients receiving intravenous thrombolysis were retrospectively recruited in this study. Complete blood count evaluations for PNR were conducted on admission and 24 h after the treatment of thrombolysis. The poor outcome at 3months was defined as the modified Rankin Scale of 3-6. Results: In multivariate logistic regression, PNR on admission (odds ratio [OR] = 0.967, 95 % confidence interval [CI] = 0.939-0.996; P = 0.028), and 24 h PNR(OR = 0.933, 95 %CI = 0.895-0.972; P = 0.004) were all independent indicators for the 3-month poor prognosis in ischemic stroke patients receiving intravenous thrombolysis. The area under the curve of PNR on admission to predict poor functional outcomes at 3 months was 0.645 (95 %CI = 0.558-0.732; P < 0.001), and the best predictive PNR on admission value was 41.35. After the treatment of thrombolysis, the area under the curve of 24 h PNR to predict poor functional outcomes at 3 months was 0.796 (95 %CI = 0.722-0.858; P < 0.001), and the best predictive 24 h PNR value was 31.03. Conclusions: Both the PNR on admission and 24 h PNR were independently associated with poor functional outcomes. Compared with the PNR on admission, 24 h PNR may serve as a more reliable marker for a poor prognosis in ischemic stroke patients receiving intravenous thrombolysis.
出版者	ELSEVIER
出版地	AMSTERDAM
ISSN	0303-8467
EISSN	1872-6968
卷号	190 页码:105739
DOI	10.1016/j.clineuro.2020.105739
页数	6
WOS类目	Clinical Neurology ; Surgery
WOS研究方向	Neurosciences & Neurology ; Surgery
WOS记录号	WOS:000521514800021
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	32105907
SCOPUSEID	2-s2.0-85079640352
通讯作者地址	[Zhou, Chengye]Department of Rehabilitation,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China
Scopus学科分类	Surgery;Neurology (clinical)
引用统计	被引频次：9[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/14307
专题	第一临床医学院（信息与工程学院）、附属第一医院_内科学_神经内科附属第一医院_康复科
通讯作者	Zhou, Chengye
作者单位	1.Department of Neurology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China; 2.Department of Rehabilitation,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China
第一作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
通讯作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Pan, Hong,Fu, Mei,Ge, Wanqian,et al. The effects of changes in platelet-to-neutrophil ratios 24 hours after intravenous thrombolysis on prognosis in acute ischemic stroke patients[J]. CLINICAL NEUROLOGY AND NEUROSURGERY,2020,190:105739.
APA	Pan, Hong, Fu, Mei, Ge, Wanqian, & Zhou, Chengye. (2020). The effects of changes in platelet-to-neutrophil ratios 24 hours after intravenous thrombolysis on prognosis in acute ischemic stroke patients. CLINICAL NEUROLOGY AND NEUROSURGERY, 190, 105739.
MLA	Pan, Hong,et al."The effects of changes in platelet-to-neutrophil ratios 24 hours after intravenous thrombolysis on prognosis in acute ischemic stroke patients".CLINICAL NEUROLOGY AND NEUROSURGERY 190(2020):105739.