The Correlation between Atrial Fibrillation and Prognosis and Hemorrhagic Transformation

doi:10.1159/000504191

科研成果详情

题名	The Correlation between Atrial Fibrillation and Prognosis and Hemorrhagic Transformation
作者	Dang, Hui; Ge, Wan-Qian; Zhou, Chao-Fan; Zhou, Cheng-Ye
发表日期	2020-03
发表期刊	EUROPEAN NEUROLOGY 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Atrial fibrillation Acute ischemic stroke Prognosis Modified Rankin Scale
其他关键词	ACUTE ISCHEMIC-STROKE ; TISSUE-PLASMINOGEN ACTIVATOR ; RISK-FACTORS ; THROMBOLYSIS ; ALTEPLASE ; PREVENTION ; PREDICTOR ; FREQUENCY ; OUTCOMES ; REGISTRY
摘要	Objective: Atrial fibrillation (AF) is the recognized risk factor for hemorrhagic transformation (HT) in thrombolysis patients with acute ischemic stroke (AIS). But the impact of AF on prognosis is still controversial. In our study, we aimed to assess the relationship between AF and HT and prognosis. Methods: We assessed 184 patients diagnosed with AIS and received thrombolysis from January 2016 to October 2017. Based on the imaging results during hospitalization, the patients were divided into HT and non-HT groups in which the HT was containing 40 patients. According to the modified Rankin Scale (mRS), we divided the patients into favorable prognosis (mRS score of 0-2) and the poor (mRS score >2) after 3 and 6 months of follow-up. Our analysis included demographics, onset to treatment time, initial blood pressure, baseline National Institutes of Health Stroke Scale (NIHSS) score, HT, anticoagulants, AF, smoking, and other past history. Results: At baseline, there was a significant difference (p < 0.05) between the HT and non-HT groups in the level of age, hyperlipidemia, AF, NIHSS, and the application of anticoagulants. After 3 and 6 months of follow-up, we found that only NIHSS (OR_{3 month} 1.421, 95% CI 1.280-1.578, p < 0.001, and OR_{6 month} 1.326, 95% CI 1.217-1.445, p < 0.001) was associated with prognosis instead of AF, HT, and anticoagulants. Meanwhile, patients with AF tended to be older, higher NIHSS score and less hyperlipidemia (p < 0.05). Conclusion: The present study indicated that there is no significant correlation between AF and prognosis, although there is some indeed related with HT. That was, the prognosis with AF had a similar response trend compared with the non-AF.
出版者	KARGER
出版地	BASEL
ISSN	0014-3022
EISSN	1421-9913
卷号	82 期号:1-3 页码:9-14
DOI	10.1159/000504191
页数	6
WOS类目	Clinical Neurology ; Neurosciences
WOS研究方向	Neurosciences & Neurology
WOS记录号	WOS:000526850100002
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	31743925
SCOPUSEID	2-s2.0-85075642222
通讯作者地址	[Zhou, Cheng-Ye]Wenzhou Med Univ, Dept Rehabil, Affiliated Hosp 1, Fu Xue Lane 2, Wenzhou 325000, Zhejiang, Peoples R China.
Scopus学科分类	Neurology;Neurology (clinical)
引用统计	被引频次：8[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/14306
专题	附属第一医院_康复科
通讯作者	Zhou, Cheng-Ye
作者单位	Wenzhou Med Univ, Dept Rehabil, Affiliated Hosp 1, Fu Xue Lane 2, Wenzhou 325000, Zhejiang, Peoples R China
第一作者单位	附属第一医院_康复科
通讯作者单位	附属第一医院_康复科
第一作者的第一单位	附属第一医院_康复科
推荐引用方式 GB/T 7714	Dang, Hui,Ge, Wan-Qian,Zhou, Chao-Fan,et al. The Correlation between Atrial Fibrillation and Prognosis and Hemorrhagic Transformation[J]. EUROPEAN NEUROLOGY,2020,82(1-3):9-14.
APA	Dang, Hui, Ge, Wan-Qian, Zhou, Chao-Fan, & Zhou, Cheng-Ye. (2020). The Correlation between Atrial Fibrillation and Prognosis and Hemorrhagic Transformation. EUROPEAN NEUROLOGY, 82(1-3), 9-14.
MLA	Dang, Hui,et al."The Correlation between Atrial Fibrillation and Prognosis and Hemorrhagic Transformation".EUROPEAN NEUROLOGY 82.1-3(2020):9-14.