Region-specific metabolic characterization of the type 1 diabetic brain in mice with and without cognitive impairment

doi:10.1016/j.neuint.2020.104941

科研成果详情

题名	Region-specific metabolic characterization of the type 1 diabetic brain in mice with and without cognitive impairment
作者	Xu, Pengtao; Ning, Jie; Jiang, Qiaoying; Li, Chen; Yan, Junjie; Zhao, Liangcai; Gao, Hongchang; Zheng, Hong
发表日期	2021-02
发表期刊	NEUROCHEMISTRY INTERNATIONAL 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Brain Cognition Diabetes Metabolism Neurotransmitter Uridine
其他关键词	URIDINE TREATMENT ; MODEL
摘要	Type 1 diabetes (T1D) has been reported to cause cognitive decline, but brain metabolic changes during this process are still far from being fully understood. Here, we found that streptozotocin (STZ)-induced T1D mice exhibited impaired learning and memory at 11 weeks after STZ treatment but not at 3 weeks. Therefore, we studied metabolic alterations in six different brain regions of T1D mice with and without cognitive decline, and attempted to identify key metabolic pathways related to diabetic cognitive dysfunction. The results demonstrate that lactate had already increased in all brain regions of T1D mice prior to cognitive decline, but a decreased TCA cycle was only observed in hippocampus, cortex and striatum of T1D mice with cognitive impairment. Reduced N-acetylaspartate and choline were found in all brain regions of T1D mice, irrespective of cognitive decline. In addition, disrupted neurotransmitter metabolism was noted to occur in T1D mice before cognitive deficit. Of note, we found that the level of uridine was significantly reduced in cerebellum, cortex, hypothalamus and midbrain of T1D mice when cognitive decline was presented. Therefore, brain region-specific metabolic alterations may comprise possible biomarkers for the early-diagnosis and monitoring of diabetic cognitive decline. Moreover, down-regulated TCA cycle and pyrimidine metabolism could be closely related to T1D-associated cognitive impairment.
资助项目	National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [22074106, 81771386, 21974096]; Qianjiang Talent Project of Zhejiang Province, China [QJD1802023]
出版者	PERGAMON-ELSEVIER SCIENCE LTD
出版地	OXFORD
ISSN	0197-0186
EISSN	1872-9754
卷号	143 页码:104941
DOI	10.1016/j.neuint.2020.104941
页数	12
WOS类目	Biochemistry & Molecular Biology ; Neurosciences
WOS研究方向	Biochemistry & Molecular Biology ; Neurosciences & Neurology
WOS记录号	WOS:000617978800004
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	33333211
SCOPUSEID	2-s2.0-85097740393
通讯作者地址	[Zheng, Hong]Institute of Metabonomics & Medical NMR,School of Pharmaceutical Sciences,Wenzhou Medical University,Wenzhou,325035,China ; [Gao, Hongchang]Institute of Metabonomics & Medical NMR,School of Pharmaceutical Sciences,Wenzhou Medical University,Wenzhou,325035,China
Scopus学科分类	Cellular and Molecular Neuroscience;Cell Biology
引用统计	被引频次：1[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/14287
专题	附属第二医院_核磁共振室药学院（分析测试中心）
通讯作者	Gao, Hongchang; Zheng, Hong
作者单位	Institute of Metabonomics & Medical NMR,School of Pharmaceutical Sciences,Wenzhou Medical University,Wenzhou,325035,China
第一作者单位	药学院（分析测试中心）
通讯作者单位	药学院（分析测试中心）
第一作者的第一单位	药学院（分析测试中心）
推荐引用方式 GB/T 7714	Xu, Pengtao,Ning, Jie,Jiang, Qiaoying,et al. Region-specific metabolic characterization of the type 1 diabetic brain in mice with and without cognitive impairment[J]. NEUROCHEMISTRY INTERNATIONAL,2021,143:104941.
APA	Xu, Pengtao., Ning, Jie., Jiang, Qiaoying., Li, Chen., Yan, Junjie., ... & Zheng, Hong. (2021). Region-specific metabolic characterization of the type 1 diabetic brain in mice with and without cognitive impairment. NEUROCHEMISTRY INTERNATIONAL, 143, 104941.
MLA	Xu, Pengtao,et al."Region-specific metabolic characterization of the type 1 diabetic brain in mice with and without cognitive impairment".NEUROCHEMISTRY INTERNATIONAL 143(2021):104941.