婴幼儿先天性白内障患眼的生物学测量

doi:10.3760/cma.j.cn112142-20210518-00233

科研成果详情

题名	婴幼儿先天性白内障患眼的生物学测量
其他题名	Ocular biometry of infants and young children with congenital cataract
作者	邹锐; 赵银莹; 赵于渔; 王丹丹; 赵云娥
发表日期	2022
发表期刊	中华眼科杂志影响因子和分区
语种	中文
原始文献类型	Periodical
关键词	白内障轴长度，眼前房角膜测厚生物测量学婴儿
其他关键词	Cataract ; Axial length, eye ; Anterior chamber ; Corneal pachymetry ; Biometry ; Infant
摘要	目的:了解先天性白内障患者早期眼球生物学参数发育特点。方法:回顾性病例系列研究。选取2016年6月至2020年6月在温州医科大学附属眼视光医院杭州院区诊断为先天性白内障的169例3岁以下患者的眼轴长度、角膜屈光力、前房深度、角膜厚度等生物学测量资料，分3个年龄段进行分析。1~6月龄、7~12月龄、13~36月龄3个年龄段的患者分别有87、41、41例；双眼患者108例，单眼患者61例；晶状体非全混型患者84例，全混型患者85例。双眼患者选右眼数据，生物学参数比较采用独立样本 t检验及配对 t检验，Pearson相关检验分析月龄与生物学参数的关系。结果:1~6月龄双眼患者患眼眼轴长度为（17.59±1.19）mm，小于单眼患者患眼［（18.18±1.34）mm］，单眼患者患眼眼轴长度小于健眼［（19.01±0.93）mm］；7~12月龄单眼患者患眼眼轴长度［（19.89±0.74）mm］小于健眼［（20.48±0.43）mm］，差异均有统计学意义（ t=-2.06、-5.62、-3.47，均 P<0.05）。1~6月龄晶状体非全混型患者患眼眼轴长度小于全混型患者［（17.43±1.14）mm与（18.06±1.29）mm比较： t=-2.38， P=0.020］。非全混型单眼患者患眼与健眼眼轴长度差值与月龄呈显著正相关（ r=0.53， P=0.001）。7~12月龄单眼患者患眼角膜屈光力小于健眼［（42.41±1.82）D与（43.19±1.96）D比较： t=-2.29， P=0.038］，而13~36月龄单眼患者患眼角膜屈光力大于健眼［（43.36±2.32）D与（42.55±1.88）D比较： t=2.17， P=0.043］。1~6月龄单眼患者患眼前房深度小于健眼［（2.44±0.37）mm与（2.58±0.33）mm比较： t=-2.08， P=0.048］。1~6月龄和7~12月龄单眼患者患眼角膜厚度均大于健眼［（555.26±46.95）μm与（541.85±40.78）μm比较： t=3.82， P=0.001；（542.93±27.63）μm与（530.93±30.36）μm比较： t=2.26， P=0.040］。结论:先天性白内障可能影响早期眼轴长度、角膜屈光力、前房深度和角膜厚度的发育。晶状体混浊程度可能影响早期眼轴长度，6月龄前非全混型白内障患眼眼轴长度较全混型白内障患眼更短，此后非全混型白内障患眼眼轴长度逐渐超过全混型白内障患眼。
其他摘要	Objective:To understand the developmental characteristics of early ocular biological parameters in patients with congenital cataract.Methods:Retrospective case series study. The ocular biometry data such as the axial length, corneal curvature, anterior chamber depth and central corneal thickness of 169 patients under 3 years old who were diagnosed with congenital cataract in Eye Hospital of Wenzhou Medical University (Hangzhou Branch) from June 2016 to June 2020 were reviewed, and they were analyzed by 3 age groups. There were 87, 41, and 41 patients in three age groups, 1 to 6 months, 7 to 12 months, and 13 to 36 months, respectively; 108 patients with bilateral affected eyes and 61 patients with unilateral affected eyes were included; 84 patients with partial opacity lens and 85 patients with total opacity lens were included. The right eyes of the patients with bilateral congenital cataract were selected for analysis. Statistical analysis of ocular biological parameters between groups was performed using the independent samples t-test and paired samples t-test. Statistical analysis of the relationship between age in months and biological parameters was performed using the Pearson′s correlation test. Results:The axial length at the age of 1 to 6 months in the affected eyes of patients with bilateral cataract was (17.59±1.19) mm, it was shorter than the affected eyes of patients with unilateral cataract [(18.18±1.34) mm], and the axial length in the affected eyes of patients with unilateral cataract were shorter than the healthy eyes [(19.01±0.93) mm]. At the age of 7 to 12 months, the axial length in the affected eyes of patients with unilateral cataract [(19.89±0.74) mm] was shorter than the healthy eyes [(20.48±0.43) mm]. The differences were statistically significant ( t=-2.06, -5.62, -3.47, all P<0.05). The axial length in the affected eyes with partial opacity at the age of 1 to 6 months was shorter than those with total opacity [(17.43±1.14) mm vs. (18.06±1.29) mm; t=-2.38, P=0.020]. The difference in axial length (affected eyes vs. healthy eyes) was significantly correlated with the age in months in partial cataract ( r=0.53, P=0.001). The corneal curvature in the affected eyes of patients with unilateral cataract was flatter than the healthy eyes at the age of 7 to 12 months [(42.41±1.82) D vs. (43.19±1.96) D; t=-2.29, P=0.038], but was steeper at the age of 13 to 36 months [(43.36±2.32) D vs. (42.55±1.88) D; t=2.17, P=0.043]. The anterior chamber depth in the affected eyes of patients with unilateral cataract was less than the healthy eyes at the age of 1 to 6 months [(2.44±0.37) mm vs. (2.58±0.33) mm; t=-2.08, P=0.048].The central corneal thickness in the affected eyes of patients with unilateral cataract was thicker than the healthy eyes both at the age of 1 to 6 months and 7 to 12 months [(555.26±46.95) μm vs. (541.85±40.78) μm, (542.93±27.63) μm vs. (530.93±30.36) μm; t=3.82, 2.26; P=0.001, 0.040]. Conclusions:Congenital cataracts maybe affect the early development of axial length, corneal curvature, anterior chamber depth and central corneal thickness. The degree of lens opacity maybe affecte the early axial length development. The axial length in eyes with partial opacity can be shorter than those with total opacity before the age of 6 months, and thereafter gradually outnumbered the latter.
资助项目	国家自然科学基金（81870680）;浙江省卫生健康重大科技计划（WKJ-ZJ-2135）
ISSN	0412-4081
卷号	58 期号:5 页码:340-347
DOI	10.3760/cma.j.cn112142-20210518-00233
页数	8
收录类别	万方 ; CNKI ; PUBMED ; SCOPUS ; 维普 ; ISTIC ; 北大核心 ; PKU ; CSCD
URL	查看原文
PubMed ID	35511660
SCOPUSEID	2-s2.0-85129997899
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/142512
专题	眼视光学院（生物医学工程学院）、附属眼视光医院_杭州院区
作者单位	温州医科大学附属眼视光医院杭州院区，杭州　310020
第一作者单位	眼视光学院（生物医学工程学院）、附属眼视光医院_杭州院区
第一作者的第一单位	眼视光学院（生物医学工程学院）、附属眼视光医院_杭州院区
推荐引用方式 GB/T 7714	邹锐,赵银莹,赵于渔,等. 婴幼儿先天性白内障患眼的生物学测量[J]. 中华眼科杂志,2022,58(5):340-347.
APA	邹锐, 赵银莹, 赵于渔, 王丹丹, & 赵云娥. (2022). 婴幼儿先天性白内障患眼的生物学测量. 中华眼科杂志, 58(5), 340-347.
MLA	邹锐,et al."婴幼儿先天性白内障患眼的生物学测量".中华眼科杂志 58.5(2022):340-347.