Homeostatic model assessment of insulin resistance closely related to lobular inflammation in nonalcoholic fatty liver disease

doi:10.1097/MEG.0000000000001483

科研成果详情

题名	Homeostatic model assessment of insulin resistance closely related to lobular inflammation in nonalcoholic fatty liver disease
作者	Ye, Fang-Zhou 1,2; Liu, Wen-Yue3; Zheng, Kenneth I.1; Pan, Xiao-Yan3; Ma, Hong-Lei 1; Wang, Xiao-Dong 1,4; Chen, Yong-Ping1,4; Zheng, Ming-Hua1,4
发表日期	2020-01
发表期刊	EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY 影响因子和分区
语种	英语
原始文献类型	Article
关键词	homeostatic model assessment of insulin resistance insulin resistance lobular inflammation nonalcoholic fatty liver nonalcoholic steatohepatitis
其他关键词	ASSOCIATION ; NAFLD ; STEATOHEPATITIS ; PATHOGENESIS ; PREVALENCE ; DIAGNOSIS ; FIBROSIS ; GLUCOSE ; SYSTEM
摘要	Objective Insulin resistance (IR) has been established as a major risk factor for nonalcoholic fatty liver disease (NAFLD) where it exerts effects on plasma glucose homeostasis, cellular anabolism, and organ glucose uptake. Owing to paucity of studies focused on peripheral IR in relation to pathological outcome, we aim to investigate homeostatic model assessment of insulin resistance (HOMA-IR) by histological characteristics of NAFLD. Methods Liver biopsy of 588 patients was screened. After excluding etiologies other than NAFLD and factors contributing to IR, serum HOMA-IR was compared with patients' histologic features. Univariate and multivariate analyses were conducted to assess their relationship. Area under the receiver operating characteristic (AUROC) was calculated to assess the discriminatory ability of homeostatic model assessment of IR for advanced lobular inflammation (LI). Results We observed higher serum level of alanine aminotransferase, aspartate aminotransferase, gamma-glutamyl transferase, and low-density lipoprotein as HOMA-IR increased. HOMA-IR is significantly associated with severity of LI (odds ratio = 1.222, 95% confidence interval = 1.135-1.315,P < 0.001), similar association remained after adjusting for age, BMI, hemoglobin A1c, alanine aminotransferase, aspartate aminotransferase, low-density lipoprotein, high-density lipoprotein, and triglycerides (odds ratio = 1.205, 95% confidence interval = 1.102-1.317,P < 0.001). HOMA-IR is discriminant of LI with AUROC = 0.832 and cutoff = 2.995 (sensitivity = 0.938, specificity = 0.569). Conclusion This study demonstrated a strong and independent association of HOMA-IR with the severity of liver inflammation by histological evaluation in NAFLD patients without diabetes or metabolic syndrome, and its possible role in diagnosis of LI could be translated into clinical assessment of NAFLD patients with uncertainty of nonalcoholic steatohepatitis progression.
资助项目	National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81500665]; High Level Creative Talents from Department of Public Health in Zhejiang Province; Project of New Century 551 Talent Nurturing in Wenzhou
出版者	LIPPINCOTT WILLIAMS & WILKINS
出版地	PHILADELPHIA
ISSN	0954-691X
EISSN	1473-5687
卷号	32 期号:1 页码:80-86
DOI	10.1097/MEG.0000000000001483
页数	7
WOS类目	Gastroenterology & Hepatology
WOS研究方向	Gastroenterology & Hepatology
WOS记录号	WOS:000561350800014
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	31625959
SCOPUSEID	2-s2.0-85076064258
通讯作者地址	[Zheng, Ming-Hua]NAFLD Research Center,Department of Hepatology,The First Affiliated Hospital of Wenzhou Medical University,No. 2 Fuxue Lane,Wenzhou,325000,China
Scopus学科分类	Medicine (all)
引用统计	被引频次：6[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/14131
专题	第一临床医学院（信息与工程学院）、附属第一医院附属第一医院_内分泌科
通讯作者	Zheng, Ming-Hua
作者单位	1.NAFLD Research Center,Department of Hepatology,The First Affiliated Hospital of Wenzhou Medical University,No. 2 Fuxue Lane,Wenzhou,325000,China; 2.School of the First Clinical Medical Sciences,Wenzhou Medical University,China; 3.Department of Endocrinology,The First Affiliated Hospital of Wenzhou Medical University,China; 4.Institute of Hepatology,Wenzhou Medical University,Wenzhou,China
第一作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院; 温州医科大学
通讯作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Ye, Fang-Zhou,Liu, Wen-Yue,Zheng, Kenneth I.,et al. Homeostatic model assessment of insulin resistance closely related to lobular inflammation in nonalcoholic fatty liver disease[J]. EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY,2020,32(1):80-86.
APA	Ye, Fang-Zhou., Liu, Wen-Yue., Zheng, Kenneth I.., Pan, Xiao-Yan., Ma, Hong-Lei., ... & Zheng, Ming-Hua. (2020). Homeostatic model assessment of insulin resistance closely related to lobular inflammation in nonalcoholic fatty liver disease. EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, 32(1), 80-86.
MLA	Ye, Fang-Zhou,et al."Homeostatic model assessment of insulin resistance closely related to lobular inflammation in nonalcoholic fatty liver disease".EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY 32.1(2020):80-86.