Efficacy of stem cell therapy for burn wounds: a systematic review and meta-analysis of preclinical studies

doi:10.1186/s13287-020-01839-9

科研成果详情

题名	Efficacy of stem cell therapy for burn wounds: a systematic review and meta-analysis of preclinical studies
作者	Li, Yuan 1; Xia, Wei-Dong1; Van Der Merwe, Leanne 2; Dai, Wen-Tong 1; Lin, Cai1
发表日期	2020-07-29
发表期刊	STEM CELL RESEARCH & THERAPY 影响因子和分区
语种	英语
原始文献类型	Review
关键词	Burns Stem cell therapy Wound healing Meta-analysis Preclinical study
其他关键词	VASCULAR FRACTION CELLS ; PLATELET-RICH PLASMA ; GROWTH-FACTOR ; THICKNESS BURNS ; HAIR-FOLLICLES ; DERMAL GRAFT ; SKIN-GRAFTS ; REEPITHELIALIZATION ; EPIDEMIOLOGY ; REPAIR
摘要	BackgroundBurns remain a serious public health problem with high morbidity and mortality rates worldwide. Although there are various treatment options available, there is no consensus on the best treatment for severe burns as of yet. Stem cell therapy has a bright prospect in many preclinical studies of burn wounds. The systematic review was performed for these preclinical studies to assess the efficacy and possible mechanisms of stem cells in treating burn wounds.MethodsTwenty-two studies with 595 animals were identified by searching PubMed, EMBASE, Web of Science, and Cochrane Library databases from inception to 13 May 2020. In addition, a manual search of references of studies was performed to obtain potential studies. No language or time restrictions were enforced. RevMan 5.3 was used for all data analysis.ResultsThe overall meta-analysis showed that stem cell therapy significantly improved burn healing rate (SMD 3.06, 95% CI 1.98 to 4.14), irrespective of transplant type, burn area, and treatment method in the control group. Subgroup analyses indicated that hair follicle stem cells seemed to exert more beneficial effects on animals with burn wounds (SMD 7.53, 95% CI 3.11 to 11.95) compared with other stem cells. Furthermore, stem cell therapy seemed to exert more beneficial effects on burn wounds with second-degree (SMD 7.53, 95% CI 3.11 to 11.95) compared with third-degree (SMD 2.65, 95% CI 1.31 to 4.00).ConclusionsMeta-analysis showed that stem cell therapy exerts a healing function for burn wounds, mainly through angiogenesis and anti-inflammatory actions. These findings also demonstrate the need for considering variations in future clinical studies using stem cells to treat a burn wound in order to maximize the effectiveness. In general, stem cells can potentially become a novel therapy candidate for burn wounds.
资助项目	Key Science and Technology Program of Zhejiang Province [2017C01054]
出版者	BMC
出版地	LONDON
ISSN	1757-6512
EISSN	1757-6512
卷号	11 期号:1 页码:322
DOI	10.1186/s13287-020-01839-9
页数	12
WOS类目	Cell & Tissue Engineering ; Cell Biology ; Medicine, Research & Experimental
WOS研究方向	Cell Biology ; Research & Experimental Medicine
WOS记录号	WOS:000557708100003
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	32727568
PMC记录号	PMC7389817
SCOPUSEID	2-s2.0-85088852532
通讯作者地址	[Lin, Cai]Department of Burn,First Affiliated Hospital of Wenzhou Medical University,Nan Bai Xiang, Wenzhou,Zhejiang,325000,China
Scopus学科分类	Medicine (miscellaneous);Molecular Medicine;Biochemistry, Genetics and Molecular Biology (miscellaneous);Cell Biology
TOP期刊	TOP期刊
引用统计	被引频次：7[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/14113
专题	附属第一医院国际教育学院
通讯作者	Lin, Cai
作者单位	1.Department of Burn,First Affiliated Hospital of Wenzhou Medical University,Nan Bai Xiang, Wenzhou,Zhejiang,325000,China; 2.School of International Studies,Wenzhou Medical University,Wenzhou Zhejiang,325000,China
第一作者单位	附属第一医院
通讯作者单位	附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Li, Yuan,Xia, Wei-Dong,Van Der Merwe, Leanne,et al. Efficacy of stem cell therapy for burn wounds: a systematic review and meta-analysis of preclinical studies[J]. STEM CELL RESEARCH & THERAPY,2020,11(1):322.
APA	Li, Yuan, Xia, Wei-Dong, Van Der Merwe, Leanne, Dai, Wen-Tong, & Lin, Cai. (2020). Efficacy of stem cell therapy for burn wounds: a systematic review and meta-analysis of preclinical studies. STEM CELL RESEARCH & THERAPY, 11(1), 322.
MLA	Li, Yuan,et al."Efficacy of stem cell therapy for burn wounds: a systematic review and meta-analysis of preclinical studies".STEM CELL RESEARCH & THERAPY 11.1(2020):322.