Factors predictive of papillary thyroid micro-carcinoma with bilateral involvement and central lymph node metastasis: a retrospective study

doi:10.1186/1477-7819-10-67

科研成果详情

题名	Factors predictive of papillary thyroid micro-carcinoma with bilateral involvement and central lymph node metastasis: a retrospective study
作者	Zhou, Yi-Li; Gao, Er-Ii; Zhang, Wei; Yang, Han; Guo, Gui-Long; Zhang, Xiao-Hua; Wang, Ou-Chen
发表日期	2012-04-27
发表期刊	WORLD JOURNAL OF SURGICAL ONCOLOGY 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Papillary micro-carcinoma Bilateral thyroid cancer Multifocality Thyroidectomy Central lymph node metastasis
其他关键词	COMPLETION THYROIDECTOMY ; PROGNOSTIC-FACTORS ; MICROCARCINOMA ; CANCER ; RECURRENCE ; STRATEGY ; PATTERN ; SIZE
摘要	Background: The optimal resection extent for papillary thyroid microcarcinoma (PTMC) remains controversial. The objective of the study was to investigate risk factors of bilateral PTMC and central lymph node metastasis (CLNM) to guide surgical strategies for PTMC patients. Methods: We retrospectively reviewed 211 PTMC patients who underwent total thyroidectomy (TT) and 122 clinical lymph node-negative (cN0) cases that underwent prophylactic central lymph node dissection (CLND) between 2010 and 2011. The frequency, pattern, and predictive factors for bilateral PTMC and CLNM in these patients were studied using univariate and multivariate analysis with respect to the following variables: age, gender, extrathyroidal extension (ETE), T stage, with Hashimoto thyroiditis (HT), tumor size and multifocality based on final pathology, and preoperative evaluation using ultrasonography (US). Results: Fifty-four of 211 (25.6%) patients had bilateral PTMC. In multivariate analysis, multifocality (P < 0.001, OR = 23.900) and tumor size >= 7 mm (P = 0.014, OR = 2.398) based on US were independent predictive factors for bilateral PTMC which was also independently associated with multifocality (P < 0.001, OR = 29.657) and tumor size >= 7 mm (P = 0.005, OR = 2.863) based on final pathology. Among 122 cN0 patients who underwent prophylactic CLND, we found 49.2% of patients had CLNM. CLNM was independently associated with men, age < 50 years and tumor size >= 7 mm based on final pathology or preoperative US. Conclusions: TT should be considered for PTMC patients who are found multifocality and tumor size >= 7 mm based on preoperative US. CLND need be considered in cN0 patients who are men, aged < 50 years or tumor size >= 7 mm based on preoperative US.
资助项目	National 863 project of China [2012AA020315]; Zhejiang Provincial Natural Science Foundation in China [Y207526]
出版者	BIOMED CENTRAL LTD
出版地	LONDON
ISSN	1477-7819
卷号	10 页码:67
DOI	10.1186/1477-7819-10-67
页数	6
WOS类目	Oncology ; Surgery
WOS研究方向	Oncology ; Surgery
WOS记录号	WOS:000304471200001
收录类别	SCIE ; PUBMED
URL	查看原文
PubMed ID	22540396
PMC记录号	PMC3356598
通讯作者地址	[Zhang, Xiao-Hua]Wenzhou Med Coll, Affiliated Hosp 1, Dept Oncol, 2 Fuxue Lane, Wenzhou, Zhejiang, Peoples R China.
引用统计	被引频次：56[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/14071
专题	附属第一医院_肿瘤内科
通讯作者	Zhang, Xiao-Hua
作者单位	Wenzhou Med Coll, Affiliated Hosp 1, Dept Oncol, Wenzhou, Zhejiang, Peoples R China
第一作者单位	附属第一医院_肿瘤内科
通讯作者单位	附属第一医院_肿瘤内科
第一作者的第一单位	附属第一医院_肿瘤内科
推荐引用方式 GB/T 7714	Zhou, Yi-Li,Gao, Er-Ii,Zhang, Wei,et al. Factors predictive of papillary thyroid micro-carcinoma with bilateral involvement and central lymph node metastasis: a retrospective study[J]. WORLD JOURNAL OF SURGICAL ONCOLOGY,2012,10:67.
APA	Zhou, Yi-Li., Gao, Er-Ii., Zhang, Wei., Yang, Han., Guo, Gui-Long., ... & Wang, Ou-Chen. (2012). Factors predictive of papillary thyroid micro-carcinoma with bilateral involvement and central lymph node metastasis: a retrospective study. WORLD JOURNAL OF SURGICAL ONCOLOGY, 10, 67.
MLA	Zhou, Yi-Li,et al."Factors predictive of papillary thyroid micro-carcinoma with bilateral involvement and central lymph node metastasis: a retrospective study".WORLD JOURNAL OF SURGICAL ONCOLOGY 10(2012):67.