Effect of Extracellular Vesicles on Neural Functional Recovery and Immunologic Suppression after Rat Cerebral Apoplexy

doi:10.1159/000452533

科研成果详情

题名	Effect of Extracellular Vesicles on Neural Functional Recovery and Immunologic Suppression after Rat Cerebral Apoplexy
作者	Hu, Beilei1; Chen, Songfang1; Zou, Ming1; He, Zhiyong1; Shao, Shengmin1; Liu, Baohua2
发表日期	2016-12-31
发表期刊	CELLULAR PHYSIOLOGY AND BIOCHEMISTRY 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Cerebral apoplexy Mesenchymal stem cells Neural functional recovery Immunologic suppression
其他关键词	MARROW STROMAL CELLS ; STEM-CELLS ; ISCHEMIC-STROKE ; TRANSPLANTATION ; EXOSOMES ; PREECLAMPSIA ; MECHANISMS ; INJURY
摘要	Background: Previous studies have demonstrated that mesenchymal stem cells (MSCs) can promote the recovery of neural function after cerebral apoplexy by secreting multiple cytokines. In addition, cell factor-derived extracellular vesicles play an important role in recovery of neural function. The aim of this study was to determine the effect of extracellular vesicles on neural functional recovery and brain tissue remodeling after cerebral apoplexy in a rat model. Methods: The rat models with local ischemic stroke was established and three random groups were created. In groups A and B, human bone marrow-derived MSCs and MSC-derived extracellular vesicles were transplanted into rats. In the control group (group C), only normal saline was injected. Then, we evaluated motor coordination ability, pathologic changes of the brain, immune responses in the central and peripheral nervous systems, regeneration of blood vessels, and nervous tissue in 4 weeks after cerebral apoplexy. Results: Obvious regeneration of blood vessels and nervous tissues were identified in groups A and B. There was no significant difference with respect to coordination between groups A and B, but coordination in groups A and B was significantly better than the control group. Immunohistochemical staining of brain tissue showed that extracellular vesicles exerted no effect on infiltration of immune cells in the central nervous system. Weakened immune suppression was noted 1 week after cerebral apoplexy, which provided a favorable environment for remodeling of brain tissue. Conclusion: MSC-derived extracellular vesicles accelerated neural functional recovery after cerebral apoplexy. The weakened immune suppression was beneficial to remodeling of brain tissue. (C) 2016 The Author(s) Published by S. Karger AG, Basel
资助项目	Medical and health science and technology plan of Zhejiang Province [2013RCA036]
出版者	KARGER
出版地	BASEL
ISSN	1015-8987
EISSN	1421-9778
卷号	40 期号:1-2 页码:155-162
DOI	10.1159/000452533
页数	8
WOS类目	Cell Biology ; Physiology
WOS研究方向	Cell Biology ; Physiology
WOS记录号	WOS:000389243900014
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	27855369
SCOPUSEID	2-s2.0-84997497914
通讯作者地址	[Liu, Baohua]Wenzhou Med Univ, Affiliated Hosp 2, Dept Rehabil Med, 109 Xue Yuan Xi Rd, Wenzhou 325000, Peoples R China.
Scopus学科分类	Physiology
TOP期刊	TOP期刊
引用统计	被引频次：27[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/14039
专题	第二临床医学院、附属第二医院、育英儿童医院附属第二医院附属第二医院_神经内科附属第二医院_康复科
通讯作者	Liu, Baohua
作者单位	1.Wenzhou Med Univ, Affiliated Hosp 2, Dept Neurol, Wenzhou, Peoples R China; 2.Wenzhou Med Univ, Affiliated Hosp 2, Dept Rehabil Med, 109 Xue Yuan Xi Rd, Wenzhou 325000, Peoples R China
第一作者单位	附属第二医院; 第二临床医学院，附属第二医院、育英儿童医院; 神经内科
通讯作者单位	附属第二医院; 第二临床医学院，附属第二医院、育英儿童医院; 康复科
第一作者的第一单位	附属第二医院
推荐引用方式 GB/T 7714	Hu, Beilei,Chen, Songfang,Zou, Ming,et al. Effect of Extracellular Vesicles on Neural Functional Recovery and Immunologic Suppression after Rat Cerebral Apoplexy[J]. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY,2016,40(1-2):155-162.
APA	Hu, Beilei, Chen, Songfang, Zou, Ming, He, Zhiyong, Shao, Shengmin, & Liu, Baohua. (2016). Effect of Extracellular Vesicles on Neural Functional Recovery and Immunologic Suppression after Rat Cerebral Apoplexy. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, 40(1-2), 155-162.
MLA	Hu, Beilei,et al."Effect of Extracellular Vesicles on Neural Functional Recovery and Immunologic Suppression after Rat Cerebral Apoplexy".CELLULAR PHYSIOLOGY AND BIOCHEMISTRY 40.1-2(2016):155-162.