MiR-4319 hinders YAP expression to restrain non-small cell lung cancer growth through regulation of LIN28-mediated RFX5 stability

doi:10.1016/j.biopha.2019.108956

科研成果详情

题名	MiR-4319 hinders YAP expression to restrain non-small cell lung cancer growth through regulation of LIN28-mediated RFX5 stability
作者	Yang, Yi 1; Li, He2; Liu, Yu3; Chi, Chuang3; Ni, Jiangwei 3; Lin, Xiaoming3
发表日期	2019-07
发表期刊	BIOMEDICINE & PHARMACOTHERAPY 影响因子和分区
语种	英语
原始文献类型	Article
关键词	miR-4319 YAP LIN28 RFX5 NSCLC
其他关键词	COLORECTAL-CANCER ; MASTER REGULATOR ; LIN28 ; INVASION ; PROLIFERATION ; PROGRESSION ; APOPTOSIS
摘要	Non-small cell lung cancer (NSCLC) is demonstrated as one of the most common malignant tumors and accounts for about 25% of cancer-related deaths each year. Extensive bodies of studies have manifested that microRNAs (miRNAs) play pivotal roles in the development of numerous malignant tumors by involving in modulation of cell biological processes. Although miR-4319 has been validated to execute tumor suppressor properties in triple-negative breast cancer, explorations on the function and latent mechanism of miR-4319 participating in NSCLC are still unclear. In this study, we proved that miR-4319 acted as a tumor suppressor in NSCLC progression via restraining cell proliferation and migration as well as boosting apoptosis. Further, miR-4319 bound with LIN28 and negatively regulated the expression of LIN28. Our data unveiled that LIN28 promoted RFX5 mRNA stability and miR-4319 led to the destabilization of RFX5 by targeting LIN28. In addition, RFX5 motivated the transcription of YAP and enhanced expression of YAP abolished the miR-4319 upregulation-mediated suppressive regulation of NSCLC tumorigenesis. In conclusion, miR-4319 dampened YAP expression to mitigate the tumorigenesis of NSCLC through inhibiting LIN28-mediated RFX5 stability, which offered an insight into the molecular mechanism underlying miR-4319 in NSCLC development.
资助项目	National Nature Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81871966]; Natural Science Foundation of Zhejiang ProvinceNatural Science Foundation of Zhejiang Province [LY15H160062]
出版者	ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
出版地	ISSY-LES-MOULINEAUX
ISSN	0753-3322
EISSN	1950-6007
卷号	115 页码:108956
DOI	10.1016/j.biopha.2019.108956
页数	8
WOS类目	Medicine, Research & Experimental ; Pharmacology & Pharmacy
WOS研究方向	Research & Experimental Medicine ; Pharmacology & Pharmacy
WOS记录号	WOS:000470664600055
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
Pubmed记录号	31096145
Scopus记录号	2-s2.0-85065537087
通讯作者地址	[Lin, Xiaoming]Department of Thoracic Surgery,The First Affiliated Hospital of Wenzhou Medical University,Nanbaixiang, Ouhai District,Wenzhou,325003,China
scopus学科分类	Pharmacology
引用统计	被引频次：19[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/13976
专题	教务处_临床技能实验教学中心（挂靠）附属第一医院
通讯作者	Lin, Xiaoming
作者单位	1.Department of Clinical Skills Center,Wenzhou Medical University,Wenzhou,325000,China; 2.Department of Otolaryngology-Head and Neck Surgery,First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325003,China; 3.Department of Thoracic Surgery,the First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325003,China
第一作者单位	温州医科大学
通讯作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
第一作者的第一单位	温州医科大学
推荐引用方式 GB/T 7714	Yang, Yi,Li, He,Liu, Yu,et al. MiR-4319 hinders YAP expression to restrain non-small cell lung cancer growth through regulation of LIN28-mediated RFX5 stability[J]. BIOMEDICINE & PHARMACOTHERAPY,2019,115:108956.
APA	Yang, Yi, Li, He, Liu, Yu, Chi, Chuang, Ni, Jiangwei, & Lin, Xiaoming. (2019). MiR-4319 hinders YAP expression to restrain non-small cell lung cancer growth through regulation of LIN28-mediated RFX5 stability. BIOMEDICINE & PHARMACOTHERAPY, 115, 108956.
MLA	Yang, Yi,et al."MiR-4319 hinders YAP expression to restrain non-small cell lung cancer growth through regulation of LIN28-mediated RFX5 stability".BIOMEDICINE & PHARMACOTHERAPY 115(2019):108956.