Association between a functional interleukin 6 receptor genetic variant and the risk and functional outcome of large artery atherosclerotic stroke

doi:10.1080/00207454.2019.1688810

科研成果详情

题名	Association between a functional interleukin 6 receptor genetic variant and the risk and functional outcome of large artery atherosclerotic stroke
作者	Huang, Xiaoya1; Ye, Qiang2; Zhu, Zhenguo2; Chen, Wei 3; Chen, Yanyan 2; Li, Jia 2; Sun, Jun 4; Ye, Zusen2
发表日期	2020-04-02
发表期刊	INTERNATIONAL JOURNAL OF NEUROSCIENCE 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Interleukin 6 receptor atherosclerosis large artery atherosclerotic stroke male outcome polymorphism
其他关键词	CORONARY-HEART-DISEASE ; ISCHEMIC-STROKE ; METABOLIC SYNDROME ; SEX-DIFFERENCES ; INFLAMMATION ; OBESITY ; IDENTIFICATION ; POLYMORPHISM ; METAANALYSIS ; PREDICTORS
摘要	Purpose: To investigate whether the Asp358Ala of interleukin 6 receptor related to the risk and outcome of large artery atherosclerotic (LAA) stroke in Han Chinese. Materials and methods: A prospective cohort study was conducted on 768 patients with LAA stroke and 686 non-stroke controls. The genotypes of Asp358Ala polymorphism were determined using SNPscan technology. Associations between genotypes and the risk of LAA stroke were analyzed with logistic regression model. Results: CC genotype (P < 0.001) and AC genotype (P = 0.023) decreased the risk of LAA stroke compared with AA genotype. Multivariate logistic regression analysis revealed that CC genotype was significantly associated with the risk of LAA stroke (P = 0.002). In the subgroup analyses, polymorphisms of Asp358Ala were significantly associated with the risk of LAA stroke in additive model, dominant model and recessive model (P = 0.009, P = 0.017, P = 0.012, respectively) for male, but not for female. Further regression analysis showed that compared with participants with AA genotype and obesity, participants with CC genotype and non-obesity were less likely to suffer LAA stroke (P = 0.003). For male participants, these associations were still existed (additive model, P = 0.022). After 3-month follow-up, patients with C allele had good functional prognosis compared with patients with A allele (P = 0.009). Conclusion: The study demonstrated that the Asp358Ala polymorphism might be associated with susceptibility to the development and outcome of LAA stroke in Han Chines
资助项目	Zhejiang Provincial Natural Science Foundation - ChinaNatural Science Foundation of Zhejiang Province [LY17H090016, LQ17H090001]; Zhejiang Provincial Medical and Health Science Technology Project - China [2018KY122]; Wenzhou Science & Technology Bureau [Y20180135]
出版者	TAYLOR & FRANCIS LTD
出版地	ABINGDON
ISSN	0020-7454
EISSN	1563-5279
卷号	130 期号:4 页码:355-362
DOI	10.1080/00207454.2019.1688810
页数	8
WOS类目	Neurosciences
WOS研究方向	Neurosciences & Neurology
WOS记录号	WOS:000495915200001
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	31679401
SCOPUSEID	2-s2.0-85074976198
通讯作者地址	[Sun, Jun]Department of Neurosurgery,Wenzhou Central Hospital & Dingli Clinical Institute of Wenzhou Medical University,No. 32 Dajian Lane, West Riverside Road, Lucheng District,Wenzhou,325000,China
Scopus学科分类	Neuroscience (all)
引用统计	被引频次：3[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/1393
专题	第二临床医学院、附属第二医院、育英儿童医院_神经病学附属第二医院附属第一医院第二临床医学院、附属第二医院、育英儿童医院其他_定理临床学院（温州市中心医院）第一临床医学院（信息与工程学院）、附属第一医院_内科学_神经内科
通讯作者	Sun, Jun
作者单位	1.Department of Neurology,Wenzhou Central Hospital & Dingli Clinical Institute of Wenzhou Medical University,Wenzhou,China; 2.Department of Neurology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China; 3.Department of Radiology,The Second Affiliated Hospital of Wenzhou Medical University,Wenzhou,China; 4.Department of Neurosurgery,Wenzhou Central Hospital & Dingli Clinical Institute of Wenzhou Medical University,Wenzhou,China
第一作者单位	温州医科大学
通讯作者单位	温州医科大学
第一作者的第一单位	温州医科大学
推荐引用方式 GB/T 7714	Huang, Xiaoya,Ye, Qiang,Zhu, Zhenguo,et al. Association between a functional interleukin 6 receptor genetic variant and the risk and functional outcome of large artery atherosclerotic stroke[J]. INTERNATIONAL JOURNAL OF NEUROSCIENCE,2020,130(4):355-362.
APA	Huang, Xiaoya., Ye, Qiang., Zhu, Zhenguo., Chen, Wei., Chen, Yanyan., ... & Ye, Zusen. (2020). Association between a functional interleukin 6 receptor genetic variant and the risk and functional outcome of large artery atherosclerotic stroke. INTERNATIONAL JOURNAL OF NEUROSCIENCE, 130(4), 355-362.
MLA	Huang, Xiaoya,et al."Association between a functional interleukin 6 receptor genetic variant and the risk and functional outcome of large artery atherosclerotic stroke".INTERNATIONAL JOURNAL OF NEUROSCIENCE 130.4(2020):355-362.