miR-320 inhibited ovarian cancer oncogenicity via targeting TWIST1 expression

科研成果详情

题名	miR-320 inhibited ovarian cancer oncogenicity via targeting TWIST1 expression
作者	Li, Chunyang1; Duan, Ping2; Wang, Jianguang1; Lu, Xiaosheng3; Cheng, Jing 3
发表日期	2017-12-31
发表期刊	AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Ovarian cancer microRNAs miR-320 TWIST1
其他关键词	FATTY-ACID SYNTHASE ; GASTRIC-CANCER ; UP-REGULATION ; HEPATOCELLULAR-CARCINOMA ; MESENCHYMAL TRANSITION ; MICRORNA EXPRESSION ; THERAPEUTIC TARGETS ; CELL-PROLIFERATION ; TUMOR-SUPPRESSOR ; BREAST-CANCER
摘要	Ovarian cancer is the most lethal gynecological cancer in most countries. Increasing studies have demonstrated that dysregulation of microRNAs (miRNAs) can contribute to cancer progression. In this study, we showed that miR-320 was underexpressed in ovarian cancer samples compared to their non-tumor tissues. The expression of Twist homolog 1 (TWIST1) in ovarian cancer tissues was upregulated compared with that in the non-tumorous tissues. We found that the expression of TWIST1 was inversely correlated with that of miR-320 in the ovarian cancer. Overexpression of miR-320 suppressed cell proliferation, cell cycle and invasion in ovarian cancer. We identified TWIST1 as a direct target gene of miR-320 in the ovarian cancer cell. Overexpression of TWIST1 promoted the ovarian cancer cell proliferation, cell cycle and invasion. Ectopic expression of TWIST1 restored the effects of miR-320 on cell proliferation, cell cycle and invasion. These findings revealed that miR-320 was a tumor suppressive gene that supressed cell prloferation, cycle and invasion through targeting TWIST1 in ovarian cancer.
资助项目	Natural Sciences Fund of Zhejiang Province [LY13C060003]; Public welfare projects, Department of science, Zhejiang Province, China [2014C37003]
出版者	E-CENTURY PUBLISHING CORP
出版地	MADISON
ISSN	1943-8141
卷号	9 期号:8 页码:3705-3713
页数	9
WOS类目	Oncology ; Medicine, Research & Experimental
WOS研究方向	Oncology ; Research & Experimental Medicine
WOS记录号	WOS:000408619700016
收录类别	SCIE ; SCOPUS
URL	查看原文
PubMed ID	28861161
SCOPUSEID	2-s2.0-85028297292
通讯作者地址	[Cheng, Jing]Reproductive Health Center,The Second Affiliated Hospital,Yuying Children’s Hospital of Wenzhou Medical University,Wenzhou,325027,China
Scopus学科分类	Molecular Medicine;Clinical Biochemistry;Cancer Research
引用统计	被引频次：26[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/13847
专题	基础医学院（机能实验教学中心）_生物科学系_生物化学与分子生物学附属第二医院
通讯作者	Cheng, Jing
作者单位	1.Department of Biochemistry,School of Basic Sciences,Wenzhou Medical University,Wenzhou,325000,China; 2.Department of Obstetrics and Gynecology,The Second Affiliated Hospital,Yuying Children’s Hospital of Wenzhou Medical University,Wenzhou,325027,China; 3.Reproductive Health Center,The Second Affiliated Hospital,Yuying Children’s Hospital of Wenzhou Medical University,Wenzhou,325027,China
第一作者单位	基础医学院（机能实验教学中心）_生物科学系_生物化学与分子生物学
通讯作者单位	附属第二医院
第一作者的第一单位	基础医学院（机能实验教学中心）_生物科学系_生物化学与分子生物学
推荐引用方式 GB/T 7714	Li, Chunyang,Duan, Ping,Wang, Jianguang,et al. miR-320 inhibited ovarian cancer oncogenicity via targeting TWIST1 expression[J]. AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH,2017,9(8):3705-3713.
APA	Li, Chunyang, Duan, Ping, Wang, Jianguang, Lu, Xiaosheng, & Cheng, Jing. (2017). miR-320 inhibited ovarian cancer oncogenicity via targeting TWIST1 expression. AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH, 9(8), 3705-3713.
MLA	Li, Chunyang,et al."miR-320 inhibited ovarian cancer oncogenicity via targeting TWIST1 expression".AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH 9.8(2017):3705-3713.