Curcumin improves memory deficits by inhibiting HMGB1-RAGE/TLR4-NF-kappa B signalling pathway in APPswe/PS1dE9 transgenic mice hippocampus

doi:10.1111/jcmm.16855

科研成果详情

题名	Curcumin improves memory deficits by inhibiting HMGB1-RAGE/TLR4-NF-kappa B signalling pathway in APPswe/PS1dE9 transgenic mice hippocampus
作者	Han, Yuan 1,2; Chen, Rui1,2; Lin, Qicheng 1,2; Liu, Yu 1,2; Ge, Wenwei 1,2; Cao, Hong1,2; Li, Jun1,2
发表日期	2021-09
发表期刊	JOURNAL OF CELLULAR AND MOLECULAR MEDICINE 影响因子和分区
语种	英语
原始文献类型	Article
关键词	advanced glycosylation end product-specific receptor Curcumin HMGB1 protein nuclear factor kappa B Toll-like receptor 4
其他关键词	ALZHEIMERS-DISEASE ; PATHOLOGY ; INFLAMMATION ; EXPRESSION ; RECEPTORS ; HMGB1
摘要	Amyloid-beta (A beta) deposition in the brain has been implicated in the development of Alzheimer's disease (AD), and neuroinflammation generates AD progression. Therapeutic effects of anti-inflammatory approaches in AD are still under investigation. Curcumin, a potent anti-inflammatory and antioxidant, has demonstrated therapeutic potential in AD models. However, curcumin's anti-inflammatory molecular mechanisms and its associated cognitive impairment mechanisms in AD remain unclear. The high-mobility group box-1 protein (HMGB1) participates in the regulation of neuroinflammation. Herein, we attempted to evaluate the anti-inflammatory effects of chronic oral administration of curcumin and HMGB1 expression in APP/PS1 transgenic mice AD model. We found that transgenic mice treated with a curcumin diet had shorter escape latencies and showed a significant increase in percent alternation, when compared with transgenic mice, in the Morris water maze and Y-maze tests. Additionally, curcumin treatment could effectively decrease HMGB1 protein expression, advanced glycosylation end product-specific receptor (RAGE), Toll-like receptors-4 (TLR4) and nuclear factor kappa B (NF-kappa B) in transgenic mice hippocampus. However, amyloid plaques detected with thioflavin-S staining in transgenic mice hippocampus were not affected by curcumin treatment. In contrast, curcumin significantly decreased GFAP-positive cells, as assessed by immunofluorescence staining. Taken together, these data indicate that oral administration of curcumin may be a promising agent to attenuate memory deterioration in AD mice, probably inhibiting the HMGB1-RAGE/TLR4-NF-kappa B inflammatory signalling pathway.
资助项目	National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81271204]; Natural Science Foundation of Zhejiang ProvinceNatural Science Foundation of Zhejiang Province [LY17H090015, LY21H090017]
出版者	WILEY
出版地	HOBOKEN
ISSN	1582-1838
EISSN	1582-4934
卷号	25 期号:18 页码:8947-8956
DOI	10.1111/jcmm.16855
页数	10
WOS类目	Cell Biology ; Medicine, Research & Experimental
WOS研究方向	Cell Biology ; Research & Experimental Medicine
WOS记录号	WOS:000685864300001
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	34405526
PMC记录号	PMC8435415
SCOPUSEID	2-s2.0-85112707713
通讯作者地址	[Cao, Hong]Department of Anesthesiology and Perioperative Medicine,The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University,Wenzhou,China ; [Li, Jun]Department of Anesthesiology and Perioperative Medicine,The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University,Wenzhou,China
Scopus学科分类	Molecular Medicine;Cell Biology
TOP期刊	TOP期刊
引用统计	被引频次：6[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/13759
专题	第二临床医学院、附属第二医院、育英儿童医院附属第二医院_麻醉重点学科实验室
通讯作者	Cao, Hong; Li, Jun
作者单位	1.Department of Anesthesiology and Perioperative Medicine,The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University,Wenzhou,China; 2.Zhejiang Province Key Laboratory of Anesthesiology,Wenzhou Medical University,Wenzhou,China
第一作者单位	第二临床医学院，附属第二医院、育英儿童医院; 附属第二医院; 温州医科大学
通讯作者单位	第二临床医学院，附属第二医院、育英儿童医院; 附属第二医院
第一作者的第一单位	第二临床医学院，附属第二医院、育英儿童医院
推荐引用方式 GB/T 7714	Han, Yuan,Chen, Rui,Lin, Qicheng,et al. Curcumin improves memory deficits by inhibiting HMGB1-RAGE/TLR4-NF-kappa B signalling pathway in APPswe/PS1dE9 transgenic mice hippocampus[J]. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE,2021,25(18):8947-8956.
APA	Han, Yuan., Chen, Rui., Lin, Qicheng., Liu, Yu., Ge, Wenwei., ... & Li, Jun. (2021). Curcumin improves memory deficits by inhibiting HMGB1-RAGE/TLR4-NF-kappa B signalling pathway in APPswe/PS1dE9 transgenic mice hippocampus. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 25(18), 8947-8956.
MLA	Han, Yuan,et al."Curcumin improves memory deficits by inhibiting HMGB1-RAGE/TLR4-NF-kappa B signalling pathway in APPswe/PS1dE9 transgenic mice hippocampus".JOURNAL OF CELLULAR AND MOLECULAR MEDICINE 25.18(2021):8947-8956.