Screening Strategies for Thyroid Disorders in the First and Second Trimester of Pregnancy in China

doi:10.1371/journal.pone.0099611

科研成果详情

题名	Screening Strategies for Thyroid Disorders in the First and Second Trimester of Pregnancy in China
作者	Yang, Hong1,2; Shao, Minglong3; Chen, Liangmiao1,2; Chen, Qingshou 1,2; Yu, Lechu1,2; Cai, Lingqiao 1,2; Lin, Zhenzhen1,2; Zhang, Chi 3; Lu, Xuemian1,2
发表日期	2014-06-12
发表期刊	PLOS ONE 影响因子和分区
语种	英语
原始文献类型	Article
其他关键词	SUBCLINICAL HYPOTHYROIDISM ; WOMEN ; DYSFUNCTION ; UNIVERSAL ; DISEASE ; RISK ; COMPLICATIONS ; MANAGEMENT ; DEFICIENCY ; OUTCOMES
摘要	Background: Thyroid dysfunction during pregnancy is associated with multiple adverse outcomes, but whether all women should be screened for thyroid disorders during pregnancy remains controversial. Objective: To evaluate the effectiveness of the targeted high risk case-finding approach for identifying women with thyroid dysfunction during the first and second trimesters of pregnancy. Methods: Levels of thyroid stimulating hormone (TSH), free thyroxine (FT4), and thyroid peroxidase antibodies (TPOAb) were measured in 3882 Chinese women during the first and second trimester of pregnancy. All tested women were divided into the high risk or non-high risk groups, based on their history, findings from physical examination, or other clinical features suggestive of a thyroid disorder. Diagnosis of thyroid disorders was made according to the standard trimester-specific reference intervals. The prevalence of thyroid disorders in each group was determined, and the feasibility of a screening approach focusing exclusively on high risk women was evaluated to estimate the ability of finding women with thyroid dysfunction. Results: The prevalence of overt hypothyroidism or hyperthyroidism in the high risk group was higher than in the non-high risk group during the first trimester (0.8% vs 0, chi(2) = 7.10, p = 0.008; 1.6% vs 0.2%, chi(2) = 7.02, p = 0.008, respectively). The prevalence of hypothyroxinemia or TPOAb positivity was significantly higher in the high risk group than in the non-high risk group during the second trimester (1.3% vs 0.5%, chi(2) = 4.49, p = 0.034; 11.6% vs 8.4%, chi(2) = 6.396, p = 0.011, respectively). The total prevalence of hypothyroidism or hyperthyroidism and the prevalence of subclinical hypothyroidism or hyperthyroidism were not statistically different between the high risk and non-high risk groups, for either the first or second trimester. Conclusion: The high risk screening strategy failed to detect the majority of pregnant women with thyroid disorders. Therefore, we recommend universal screening of sTSH, FT4, and TPOAb during the first trimester and second trimester of pregnancy.
资助项目	Medical Science Research Foundation of Zhejiang Province [2009A198]; Science and technology project of Ruian city [20093092]; Ruian Science and Technology Plan [201002051]; Young Scientist Award from National Science Foundation of China [81000294]; National Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81370917]; Research Development Fund of Wenzhou Medical University [QTJ13005]
出版者	PUBLIC LIBRARY SCIENCE
出版地	SAN FRANCISCO
ISSN	1932-6203
卷号	9 期号:6 页码:e99611.
DOI	10.1371/journal.pone.0099611
页数	7
WOS类目	Multidisciplinary Sciences
WOS研究方向	Science & Technology - Other Topics
WOS记录号	WOS:000338701300081
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	24925135
PMC记录号	PMC4055732
SCOPUSEID	2-s2.0-84903398981
通讯作者地址	[Zhang, Chi]Wenzhou Med Univ, Key Lab Biotechnol Pharmaceut Engn, Sch Pharmaceut Sci, Chinese Amer Res Inst Diabet Complicat, Wenzhou, Zhejiang, Peoples R China.
Scopus学科分类	Multidisciplinary
引用统计	被引频次：16[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/13724
专题	温州医科大学其他_附属第三医院（瑞安市人民医院）药学院（分析测试中心）_生物制药系_生物制药工程
通讯作者	Zhang, Chi
作者单位	1.Wenzhou Med Univ, Dept Endocrinol, Hosp 3, Ruian, Zhejiang, Peoples R China; 2.Wenzhou Med Univ, Ruian Ctr, Hosp 3, Chinese Amer Res Inst Diabet Complicat, Ruian, Zhejiang, Peoples R China; 3.Wenzhou Med Univ, Key Lab Biotechnol Pharmaceut Engn, Sch Pharmaceut Sci, Chinese Amer Res Inst Diabet Complicat, Wenzhou, Zhejiang, Peoples R China
第一作者单位	温州医科大学; 其他_附属第三医院（瑞安市人民医院）
通讯作者单位	药学院（分析测试中心）_生物制药系_生物制药工程
第一作者的第一单位	温州医科大学
推荐引用方式 GB/T 7714	Yang, Hong,Shao, Minglong,Chen, Liangmiao,et al. Screening Strategies for Thyroid Disorders in the First and Second Trimester of Pregnancy in China[J]. PLOS ONE,2014,9(6):e99611..
APA	Yang, Hong., Shao, Minglong., Chen, Liangmiao., Chen, Qingshou., Yu, Lechu., ... & Lu, Xuemian. (2014). Screening Strategies for Thyroid Disorders in the First and Second Trimester of Pregnancy in China. PLOS ONE, 9(6), e99611..
MLA	Yang, Hong,et al."Screening Strategies for Thyroid Disorders in the First and Second Trimester of Pregnancy in China".PLOS ONE 9.6(2014):e99611..