DOPAMINE INDUCES GLUTAMATE ACCUMULATION IN ASTROCYTES TO DISRUPT NEURONAL FUNCTION LEADING TO PATHOGENESIS OF MINIMAL HEPATIC ENCEPHALOPATHY

doi:10.1016/j.neuroscience.2017.09.040

科研成果详情

题名	DOPAMINE INDUCES GLUTAMATE ACCUMULATION IN ASTROCYTES TO DISRUPT NEURONAL FUNCTION LEADING TO PATHOGENESIS OF MINIMAL HEPATIC ENCEPHALOPATHY
作者	Ding, Saidan1; Wang, Xuebao 2; Zhuge, Weishan 3; Yang, Jianjing4; Zhuge, Qichuan4
发表日期	2017-12-04
发表期刊	NEUROSCIENCE 影响因子和分区
语种	英语
原始文献类型	Article
关键词	minimal hepatic encephalopathy dopamine glutamate Brain-Derived Nerve Growth Factor neurotrophin-3
其他关键词	AMINO-ACID TRANSPORTERS ; NEUROTROPHIC-FACTOR ; OXIDATIVE STRESS ; RECEPTOR 1 ; IN-VIVO ; CALCINEURIN ; AMPA ; ACTIVATION ; BDNF ; NMDA
摘要	Minimal hepatic encephalopathy (MHE) is Induced by elevated intracranial dopamine (DA). Glutamate (Glu) toxicity is known to be involved In many neurological disorders. In this study, we investigated whether DA increased Glu levels and collaborated with Glu to impair memory. We found that DA upregulated TAAR1, leading to reduced EAAT2 expression and Glu clearance in primary cortical astrocytes (PCAs). High DA increased TAAR1 expression, and high Glu Increased AMPAR expression, inducing the activation of CaN/NFAT signaling and a decrease in the production of BDNF (Brain Derived Nerve Growth Factor)/NT3 (neurotrophin-3) in primary cortical neurons (PCNs). DA activated TAAR1 to downregulate EAAT2 and increase extracellular Glu levels in MHE. Additionally, DA together with Glu caused decreased production of neuronal BDNF/NT3 and memory impairment through the activation of CaN/NFAT signaling in MHE. From these findings, we conclude that DA Increases Glu levels via interaction with TAAR1 and disruption of EAAT2 signaling in astrocytes, and DA interacting with TAAR1 and Glu interacting with AMPAR synergistically decreased the production of BDNF by activation of CaN/NFAT signaling to impair memory in MHE rats. (C) 2017 IBRO. Published by Elsevier Ltd. All rights reserved.
资助项目	National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81671042, 81300308, 81171088, 81371396]
出版者	PERGAMON-ELSEVIER SCIENCE LTD
出版地	OXFORD
ISSN	0306-4522
EISSN	1873-7544
卷号	365 页码:94-113
DOI	10.1016/j.neuroscience.2017.09.040
页数	20
WOS类目	Neurosciences
WOS研究方向	Neurosciences & Neurology
WOS记录号	WOS:000415966200009
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	28965835
SCOPUSEID	2-s2.0-85031770190
通讯作者地址	[Zhuge, Qichuan]Neurosurgery Department,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China
Scopus学科分类	Neuroscience (all)
引用统计	被引频次：9[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/13680
专题	附属第一医院药学院（分析测试中心）
通讯作者	Zhuge, Qichuan
作者单位	1.Zhejiang Provincial Key Laboratory of Aging and Neurological Disease Research,Department of Surgery Laboratory,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China; 2.Analytical and Testing Center,Wenzhou Medical University,Wenzhou,325000,China; 3.Gastrointestinal Surgery,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China; 4.Neurosurgery Department,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China
第一作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
通讯作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Ding, Saidan,Wang, Xuebao,Zhuge, Weishan,et al. DOPAMINE INDUCES GLUTAMATE ACCUMULATION IN ASTROCYTES TO DISRUPT NEURONAL FUNCTION LEADING TO PATHOGENESIS OF MINIMAL HEPATIC ENCEPHALOPATHY[J]. NEUROSCIENCE,2017,365:94-113.
APA	Ding, Saidan, Wang, Xuebao, Zhuge, Weishan, Yang, Jianjing, & Zhuge, Qichuan. (2017). DOPAMINE INDUCES GLUTAMATE ACCUMULATION IN ASTROCYTES TO DISRUPT NEURONAL FUNCTION LEADING TO PATHOGENESIS OF MINIMAL HEPATIC ENCEPHALOPATHY. NEUROSCIENCE, 365, 94-113.
MLA	Ding, Saidan,et al."DOPAMINE INDUCES GLUTAMATE ACCUMULATION IN ASTROCYTES TO DISRUPT NEURONAL FUNCTION LEADING TO PATHOGENESIS OF MINIMAL HEPATIC ENCEPHALOPATHY".NEUROSCIENCE 365(2017):94-113.