The Prognostic Values of the Insulin-Like Growth Factor Binding Protein Family in Ovarian Cancer

doi:10.1155/2020/7658782

科研成果详情

题名	The Prognostic Values of the Insulin-Like Growth Factor Binding Protein Family in Ovarian Cancer
作者	Zheng, Ruoyi1; Chen, Wenming2; Xia, Weiting1; Zheng, Jingyu3; Zhou, Qing 1
发表日期	2020-11-17
发表期刊	BIOMED RESEARCH INTERNATIONAL 影响因子和分区
语种	英语
原始文献类型	Article
其他关键词	CATENIN SIGNALING PATHWAY ; BREAST-CANCER ; MESSENGER-RNA ; SERUM-LEVELS ; LUNG-CANCER ; CROSS-TALK ; IGF-I ; EXPRESSION ; IGFBP-3 ; METASTASIS
摘要	Purpose. To assess the expression of insulin-like growth factor binding protein (IGFBP) family and its prognostic impact in ovarian cancer (OC) patients. Materials and Methods. The mRNA expression and protein expression of individual IGFBPs in healthy ovarian samples and OC tissues were explored through Oncomine, Gene Expression Profiling Interactive Analysis, and Human Protein Atlas database. Additionally, the prognostic values of the six IGFBP members in patients with OC were evaluated by Kaplan-Meier plotter. Results. IGFBP2 and IGFBP4 mRNA expression were remarkably upregulated in patients with OC. To be specific, the mRNA expression of IGFBP2 was upregulated in patients with serous ovarian cancer (SOC), while IGFBP1/3/4/5/6 mRNA levels were downregulated. In addition, the IGFBP4 protein expression was upregulated in SOC, and the IGFBP6 protein expression was upregulated in both of SOC and endometrioid ovarian cancer (EOC) tissues. High IGFBP1 mRNA levels showed favorable overall survival (OS) and progression-free survival (PFS) in all OC. Meanwhile, increased IGFBP5/6 mRNA levels revealed worsen OS and PFS in all OC patients. IGFBP4/6 mRNA levels predicted unfavorable OS and PFS only in SOC patients. Moreover, the aberrant mRNA expression of IGFBP1/2/4/5/6 was correlated with significantly prognosis in patients receiving different chemotherapeutic regimens. Conclusion. This study indicates that the IGFBP family reveals distinct prognosis in patients with OC. IGFBP1/2/4/5/6 are useful prognostic predictors for chemotherapeutic effect in OC patients, and IGFBP2/4 are potential tumor markers for the diagnosis of OC.
资助项目	Science and Technology Bureau of Wenzhou [Y20180278, Y2020937]
出版者	HINDAWI LTD
出版地	LONDON
ISSN	2314-6133
EISSN	2314-6141
卷号	2020 页码:7658782
DOI	10.1155/2020/7658782
页数	15
WOS类目	Biotechnology & Applied Microbiology ; Medicine, Research & Experimental
WOS研究方向	Biotechnology & Applied Microbiology ; Research & Experimental Medicine
WOS记录号	WOS:000595819200010
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	33282953
PMC记录号	PMC7685796
SCOPUSEID	2-s2.0-85097255783
通讯作者地址	[Zhou, Qing]Department of Gynecology,First Affiliated Hospital of Wenzhou Medical University,Wenzhou, Zhejiang,325000,China
Scopus学科分类	Biochemistry, Genetics and Molecular Biology (all);Immunology and Microbiology (all)
引用统计	被引频次：5[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/13616
专题	第一临床医学院（信息与工程学院）、附属第一医院_妇产科学_妇科附属第一医院_产科基础医学院（机能实验教学中心）_病理学与病理生理学系
通讯作者	Zhou, Qing
作者单位	1.Department of Gynecology,First Affiliated Hospital of Wenzhou Medical University,Wenzhou, Zhejiang,325000,China; 2.Department of Obstetrics,First Affiliated Hospital of Wenzhou Medical University,Wenzhou, Zhejiang,325000,China; 3.Department of Pathology,First Affiliated Hospital of Wenzhou Medical University,Wenzhou, Zhejiang,325000,China
第一作者单位	附属第一医院
通讯作者单位	附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Zheng, Ruoyi,Chen, Wenming,Xia, Weiting,et al. The Prognostic Values of the Insulin-Like Growth Factor Binding Protein Family in Ovarian Cancer[J]. BIOMED RESEARCH INTERNATIONAL,2020,2020:7658782.
APA	Zheng, Ruoyi, Chen, Wenming, Xia, Weiting, Zheng, Jingyu, & Zhou, Qing. (2020). The Prognostic Values of the Insulin-Like Growth Factor Binding Protein Family in Ovarian Cancer. BIOMED RESEARCH INTERNATIONAL, 2020, 7658782.
MLA	Zheng, Ruoyi,et al."The Prognostic Values of the Insulin-Like Growth Factor Binding Protein Family in Ovarian Cancer".BIOMED RESEARCH INTERNATIONAL 2020(2020):7658782.